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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00125


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PURL: https://purl.expasy.org/prosite/signature/PS00125

Direct ScanProsite submission
General information about the entry

Entry name [info] SER_THR_PHOSPHATASE
Accession [info] PS00125
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2001 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00115

Name and characterization of the entry

Description [info] Serine/threonine specific protein phosphatases signature.
Pattern [info] 
[LIVMN]-[KR]-G-N-H-E.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 217 in 217 different sequences
Number of true positive hits 207 in 207 different sequences
Number of 'unknown' hits 0
Number of false positive hits 10 in 10 different sequences
Number of false negative sequences 5
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 95.39 %
Recall (true positives / (true positives + false negatives)) 97.64 %

Comments [info]

Taxonomic range [info] Bacteriophages, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 207 sequences 

BSL1_ARATH  (Q8L7U5), BSL1_ORYSJ  (Q60EX6), BSL2_ARATH  (Q9SJF0), 

BSL2_ORYSJ  (Q2QM47), BSL3_ARATH  (Q9SHS7), BSU1_ARATH  (Q9LR78), 
FYPP1_ARATH (Q9SX52), FYPP3_ARATH (Q9LHE7), FYPP_PEA(Q8LSN3), 
GLC7A_CAEBR (Q61JR3), GLC7A_CAEEL (Q27497), GLC7B_CAEBR (Q627N3), 
GLC7B_CAEEL (P48727), GLC7C_CAEEL (O02658), GLC7D_CAEEL (P91420), 
PP11_ACEPE  (P48480), PP11_ARATH  (P30366), PP11_DROME  (P48461), 
PP11_SCHPO  (P13681), PP11_TOBAC  (O04856), PP11_TRYBB  (P23733), 
PP11_YEAST  (P20604), PP12_ACEPE  (P48481), PP12_ARATH  (P48482), 
PP12_DROME  (P12982), PP12_SCHPO  (P23880), PP12_TOBAC  (O04857), 
PP12_TRYBB  (P23734), PP12_YEAST  (P32598), PP13_ARATH  (P48483), 
PP13_DROME  (Q05547), PP13_TOBAC  (O04858), PP14_ARATH  (P48484), 
PP15_ARATH  (P48485), PP16_ARATH  (P48486), PP17_ARATH  (O82733), 
PP18_ARATH  (O82734), PP19_ARATH  (Q9M9W3), PP1A_BOVIN  (Q3T0E7), 
PP1A_CANLF  (Q8WMS6), PP1A_HUMAN  (P62136), PP1A_MOUSE  (P62137), 
PP1A_RABIT  (P62139), PP1A_RAT(P62138), PP1B_BOVIN  (Q3SWW9), 
PP1B_CANLF  (Q8MJ47), PP1B_CHICK  (P62207), PP1B_DROME  (P48462), 
PP1B_HUMAN  (P62140), PP1B_MOUSE  (P62141), PP1B_PIG(P61292), 
PP1B_PONAB  (Q5R740), PP1B_RABIT  (P62143), PP1B_RAT(P62142), 
PP1B_XENLA  (Q6GQL2), PP1B_XENTR  (Q5I085), PP1GA_XENLA (P36874), 
PP1GB_XENLA (Q7SZ10), PP1G_BOVIN  (P61287), PP1G_CANLF  (Q8MJ46), 
PP1G_HUMAN  (P36873), PP1G_MOUSE  (P63087), PP1G_RAT(P63088), 
PP1_BRANA   (P23777), PP1_BRAOL   (P48487), PP1_DICDI   (O15757), 
PP1_EMENI   (P20654), PP1_MAIZE   (P22198), PP1_MEDSV   (P48488), 
PP1_NEUCR   (Q9UW86), PP1_ORYSJ   (P48489), PP1_PHAVU   (P48490), 
PP2A1_ARATH (Q07099), PP2A1_EMENI (Q9HFQ2), PP2A1_NEUCR (P48580), 
PP2A1_ORYSI (A2YEB4), PP2A1_ORYSJ (Q0DBD3), PP2A1_PARTE (P48726), 
PP2A1_SCHPO (P23635), PP2A1_YEAST (P23594), PP2A2_ARATH (Q07098), 
PP2A2_BLUHO (Q8X178), PP2A2_ORYSI (A2XN40), PP2A2_ORYSJ (Q10BT5), 
PP2A2_PARTE (A0CNL9), PP2A2_SCHPO (P23636), PP2A2_YEAST (P23595), 
PP2A3_ARATH (Q07100), PP2A3_ORYSI (A2X2G3), PP2A3_ORYSJ (Q0E2S4), 
PP2A3_PARTE (Q6BFF6), PP2A4_ARATH (P48578), PP2A4_ORYSI (P0C5D7), 
PP2A4_ORYSJ (A3C4N5), PP2A4_YEAST (P32838), PP2A5_ARATH (O04951), 
PP2A5_TOBAC (O04860), PP2AA_BOVIN (P67774), PP2AA_CHICK (P48463), 
PP2AA_DICDI (Q9XZE5), PP2AA_HUMAN (P67775), PP2AA_MOUSE (P63330), 
PP2AA_PIG   (P67776), PP2AA_RABIT (P67777), PP2AA_RAT   (P63331), 
PP2AB_BOVIN (Q0P594), PP2AB_DICDI (Q54RD6), PP2AB_HUMAN (P62714), 
PP2AB_MOUSE (P62715), PP2AB_PIG   (P11493), PP2AB_RABIT (P11611), 
PP2AB_RAT   (P62716), PP2A_ACEPE  (P48577), PP2A_BRANA  (P23778), 
PP2A_CAEEL  (G5EGK8), PP2A_DROME  (P23696), PP2A_HELAN  (P48579), 
PP2A_HEVBR  (Q9ZSE4), PP2A_MEDSA  (Q06009), PP2A_TOBAC  (Q9XGH7), 
PP2B1_CRYNH (O42773), PP2B1_DROME (P48456), PP2B1_YEAST (P23287), 
PP2B2_DROME (Q27889), PP2B2_YEAST (P14747), PP2B3_DROME (Q9VXF1), 
PP2BA_BOVIN (P48452), PP2BA_DICDI (Q7YSW8), PP2BA_HUMAN (Q08209), 
PP2BA_MOUSE (P63328), PP2BA_RAT   (P63329), PP2BB_HUMAN (P16298), 
PP2BB_MOUSE (P48453), PP2BB_RAT   (P20651), PP2BC_HUMAN (P48454), 
PP2BC_MOUSE (P48455), PP2B_ASPFU  (Q4WUR1), PP2B_CAEEL  (Q0G819), 
PP2B_EMENI  (P48457), PP2B_NEUCR  (Q05681), PP2B_SCHPO  (Q12705), 
PP4C1_CAEBR (A8XE00), PP4C1_CAEEL (Q9XW79), PP4C2_CAEEL (Q9XTT8), 
PP4CA_DANRE (A8WGP3), PP4CB_DANRE (A9JRC7), PP4C_BOVIN  (A6H772), 
PP4C_CANGA  (Q6FM81), PP4C_DICDI  (Q9Y0B7), PP4C_DROME  (O76932), 
PP4C_EREGS  (Q74ZR2), PP4C_HUMAN  (P60510), PP4C_KLULA  (Q6CNT6), 
PP4C_MOUSE  (P97470), PP4C_PONAB  (Q5R6K8), PP4C_RABIT  (P11084), 
PP4C_RAT(Q5BJ92), PP4C_XENLA  (Q6IP91), PP4C_XENTR  (Q6P861), 
PP4C_YEAST  (P32345), PPE1_HUMAN  (O14829), PPE1_MOUSE  (O35655), 
PPE1_RAT(Q3SWT6), PPE1_SCHPO  (P36614), PPE2_HUMAN  (O14830), 
PPE2_MOUSE  (O35385), PPE_CAEEL   (G5EBX9), PPG1_CANAL  (Q5A6B6), 
PPIG_XENTR  (Q6NVU2), PPP5_ASPOR  (Q2U919), PPP5_HUMAN  (P53041), 
PPP5_MOUSE  (Q60676), PPP5_RAT(P53042), PPP5_SCHPO  (O43049), 
PPP5_YEAST  (P53043), PPP6_CAEEL  (Q09496), PPP6_DICDI  (Q9U9A3), 
PPP6_DROME  (Q27884), PPP6_HUMAN  (O00743), PPP6_MOUSE  (Q9CQR6), 
PPP6_RAT(Q64620), PPP7_ARATH  (Q9FN02), PPQ1_YEAST  (P32945), 
PPX1_ARATH  (P48529), PPX1_PARTE  (P49576), PPX2_ARATH  (P48528), 
PPX2_PARTE  (A0DJ90), PPX3_PARTE  (A0C1E4), PPX4_PARTE  (A0CCD2), 
PPY_DROME   (P11612), PPZ1_YEAST  (P26570), PPZ2_YEAST  (P33329), 
PPZA_ASPFC  (B0XUR7), PPZ_SCHPO   (P78968), PP_LAMBD(P03772), 
PRP1_ECOLI  (P55798), PRP1_SALTY  (Q8ZNY9), PRP2_ECOLI  (P55799), 
RDGC_DROME  (P40421), SIT4_CANAL  (Q59KY8), SITA_ASPFU  (Q4WM22), 
YD44_SCHPO  (Q10298), YL39_CAEEL  (P34430), YOU5_SCHPO  (O74789), 
YSD1_CAEEL  (P48459), YT91_CAEEL  (P48458), YY06_CAEEL  (P48460)
» more

UniProtKB/Swiss-Prot
False negative sequences		 5 sequences 

PPP5_ARATH  (Q84XU2), PPP5_SOLLC  (Q84K11), PPP7I_ARATH (Q9LEV0), 

PPP7L_ARATH (Q9LNG5), PRP2_SALTY  (Q8ZMH3)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

PPP5_RABIT  (P55739)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			10 sequences
			


			
ARSR2_HALSA (O52026), GFD1_YEAST  (Q04839), LAP1_CHAGB  (Q2H1T8), 

			
LAP1_NEUCR  (Q7RYC8), NFM_CHICK   (P16053), PYCC1_ECOLX (P0DV24), 
RPM1_CAEEL  (Q17551), SYP_SYNC1   (Q3A6R6), TASO2_MOUSE (Q5DTT3), 
XIRP2_MOUSE (Q4U4S6)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			151 PDB
			


			pdb_00001aui; pdb_00001fjm; pdb_00001g5b; pdb_00001it6; pdb_00001jk7; pdb_00001m63; pdb_00001mf8; pdb_00001s70; pdb_00001s95; pdb_00001tco; pdb_00001u32; pdb_00001wao; 
			
				pdb_00002bcd; pdb_00002bdx; pdb_00002iae; pdb_00002ie3; pdb_00002ie4; pdb_00002jog; pdb_00002npp; pdb_00002nyl; pdb_00002nym; pdb_00002o8a; pdb_00002o8g; pdb_00002p6b; 
				pdb_00003c5w; pdb_00003dw8; pdb_00003e7a; pdb_00003e7b; pdb_00003egg; pdb_00003egh; pdb_00003fga; pdb_00003h60; pdb_00003h61; pdb_00003h62; pdb_00003h63; pdb_00003h64; 
				pdb_00003h66; pdb_00003h67; pdb_00003h68; pdb_00003h69; pdb_00003hvq; pdb_00003icf; pdb_00003k7v; pdb_00003k7w; pdb_00003ll8; pdb_00003n5u; pdb_00003p71; pdb_00003v4y; 
				pdb_00004f0z; pdb_00004g9j; pdb_00004i5l; pdb_00004i5n; pdb_00004il1; pdb_00004iyp; pdb_00004ja7; pdb_00004ja9; pdb_00004lac; pdb_00004mov; pdb_00004moy; pdb_00004mp0; 
				pdb_00004or9; pdb_00004ora; pdb_00004orb; pdb_00004orc; pdb_00004ut2; pdb_00004ut3; pdb_00004v0u; pdb_00004v0v; pdb_00004v0w; pdb_00004v0x; pdb_00004xpn; pdb_00004zvz; 
				pdb_00004zx2; pdb_00005c1v; pdb_00005hpe; pdb_00005inb; pdb_00005ioh; pdb_00005j28; pdb_00005sve; pdb_00005ui1; pdb_00005w0w; pdb_00005wg8; pdb_00005zqv; pdb_00005zt0; 
				pdb_00006alz; pdb_00006czo; pdb_00006dcx; pdb_00006dno; pdb_00006g0i; pdb_00006g0j; pdb_00006ghm; pdb_00006nts; pdb_00006nuc; pdb_00006nuf; pdb_00006nuu; pdb_00006obn; 
				pdb_00006obp; pdb_00006obq; pdb_00006obr; pdb_00006obs; pdb_00006obu; pdb_00006tz7; pdb_00006tz8; pdb_00006uuq; pdb_00006zee; pdb_00006zef; pdb_00006zeg; pdb_00006zeh; 
				pdb_00006zei; pdb_00006zej; pdb_00006zk6; pdb_00007cun; pdb_00007k36; pdb_00007nzm; pdb_00007pks; pdb_00007qfb; pdb_00007qm2; pdb_00007qwj; pdb_00007sd0; pdb_00007soy; 
				pdb_00007t0y; pdb_00007tvf; pdb_00007txh; pdb_00007upi; pdb_00007ycx; pdb_00007zr5; pdb_00007zr6; pdb_00008a8f; pdb_00008b5r; pdb_00008dwk; pdb_00008dwl; pdb_00008jfw; 
				pdb_00008jfy; pdb_00008rbx; pdb_00008rbz; pdb_00008rc4; pdb_00008so0; pdb_00008sw5; pdb_00008sw6; pdb_00008ttb; pdb_00008twe; pdb_00008twi; pdb_00008u1x; pdb_00008u5g; 
				pdb_00008u89; pdb_00008uwb; pdb_00008yjb; pdb_00009b9g; pdb_00009chu; pdb_00009chv; pdb_00009chx
			
			

			» more