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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00144


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PURL: https://purl.expasy.org/prosite/signature/PS00144

Direct ScanProsite submission
General information about the entry

Entry name [info] ASN_GLN_ASE_1
Accession [info] PS00144
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00132
Associated ProRule [info] PRU10099

Name and characterization of the entry

Description [info] Asparaginase / glutaminase active site signature 1.
Pattern [info] 
[LIVM]-x-{L}-T-G-G-T-[IV]-[AGS].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 129 in 129 different sequences
Number of true positive hits 53 in 53 different sequences
Number of 'unknown' hits 1
Number of false positive hits 75 in 75 different sequences
Number of false negative sequences 18
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 41.41 %
Recall (true positives / (true positives + false negatives)) 74.65 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 7
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 53 sequences 

ASP21_YEAST (P0CZ17), ASP22_YEAST (P0CX77), ASP23_YEAST (P0CX78), 

ASP24_YEAST (P0CX79), ASPG1_BACSU (P26900), ASPG1_ECO57 (P0A963), 
ASPG1_ECOLI (P0A962), ASPG1_YEAST (P38986), ASPG2_BACSU (O34482), 
ASPG2_ECOLI (P00805), ASPG2_HAEIN (P43843), ASPG_BACLI  (P30363), 
ASPG_DEIRA  (Q9RRX9), ASPG_DICCH  (P06608), ASPG_DIRIM  (Q9U518), 
ASPG_HELPJ  (Q9ZLB9), ASPG_HELPY  (O25424), ASPG_MYCBO  (P63628), 
ASPG_MYCLE  (Q9X7E6), ASPG_MYCTO  (P9WPX4), ASPG_MYCTU  (P9WPX5), 
ASPG_THEKO  (Q5JIW4), ASPG_WOLSU  (P50286), ASPQ_ACIGL  (P10172), 
ASPQ_DELAC  (P83712), ASPQ_PSEAE  (Q9I407), ASPQ_PSEFA  (O68897), 
ASPQ_PSEPK  (Q88K39), ASPQ_PSES7  (P10182), GATD_ARCFU  (O29380), 
GATD_HALS3  (B0R6H4), GATD_HALSA  (Q9HP20), GATD_HALWD  (Q18GL3), 
GATD_METAC  (Q8TR66), GATD_METBF  (Q46GJ6), GATD_METBU  (Q12X65), 
GATD_METJA  (Q60331), GATD_METKA  (Q8TV84), GATD_METM5  (A4FWR5), 
GATD_METM6  (A9AA46), GATD_METM7  (A6VGK5), GATD_METMA  (Q8PUM7), 
GATD_METMP  (P61400), GATD_METS3  (A5UK11), GATD_METST  (Q2NEH1), 
GATD_METTH  (O26802), GATD_METVS  (A6UPR4), GATD_PYRAB  (Q9V0T9), 
GATD_PYRFU  (Q8U0X0), GATD_PYRHO  (O59132), GATD_THEAC  (Q9HJJ5), 
GATD_THEKO  (Q5JI77), GATD_THEVO  (Q979L8)
» more

UniProtKB/Swiss-Prot
False negative sequences		 18 sequences 

ASPG_PYRFU  (Q8TZE8), GATD_AERPE  (Q9Y9T8), GATD_METS5  (A4YHH3), 

GATD_NANEQ  (P61401), GATD_PYRAE  (Q8ZY04), GATD_SACI1  (C3NHQ2), 
GATD_SACI2  (C3MPS1), GATD_SACI3  (C3N5E7), GATD_SACI4  (C3MYR5), 
GATD_SACI6  (C4KH13), GATD_SACI7  (C3NE01), GATD_SACS2  (Q97ZH5), 
GATD_SULAC  (Q4J955), GATD_SULTO  (Q971W5), GATD_THEPD  (A1RX40), 
LPP60_HUMAN (Q86U10), LPP60_MOUSE (A0JNU3), LPP60_RAT   (O88202)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

DESPA_DANRE (A0A8M2BID5)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			75 sequences
			


			
API10_SOLTU (Q03197), API11_SOLTU (P16348), API1_SOLTU  (Q41480), 

			
API2_SOLTU  (Q43646), API3_SOLTU  (P58518), API4_SOLTU  (Q43645), 
API5_SOLTU  (P58519), API6_SOLTU  (P58520), API7_SOLTU  (Q41448), 
API8_SOLTU  (P17979), API9_SOLTU  (P58521), APT_BLOPB   (Q493A5), 
APT_CHLAA   (A9WCV7), APT_CLOB1   (A7FY09), APT_CLOBH   (A5I6E1), 
APT_CLOBK   (B1IME3), APT_CLOBL   (A7GHS8), APT_CLOBM   (B1L0A2), 
APT_CLOP1   (Q0TP22), APT_CLOPE   (Q8XJ22), APT_CLOPS   (Q0SRP2), 
APT_DESRM   (A4J2G8), APT_LACLA   (Q9CHT5), APT_LACLM   (A2RIW0), 
APT_LACLS   (Q031A0), APT_LACP3   (Q038P1), APT_LACPL   (Q88VH0), 
APT_LATSS   (Q38W53), APT_LEVBA   (Q03QP8), APT_LIGS1   (Q1WT53), 
APT_METM7   (A6VJW6), APT_MYCBO   (P59959), APT_MYCBP   (A1KLT2), 
APT_MYCSJ   (A3PYX7), APT_MYCSK   (A1UFB6), APT_MYCSS   (Q1B9P7), 
APT_MYCTA   (A5U5T4), APT_MYCTO   (P9WQ06), APT_MYCTU   (P9WQ07), 
APT_PEDPA   (Q03F39), APT_PROM5   (A2BXB1), APT_ROSCS   (A7NG77), 
APT_ROSS1   (A5URA4), APT_SYNC1   (Q3A4N0), APT_UREP2   (B1AJC8), 
APT_UREPA   (Q9PQ02), ATM1_CHAGB  (Q2HIE9), ATRN1_MOUSE (Q6A051), 
CDIA2_BURP2 (I1WVY3), DSCA1_DROME (Q0E9H9), KPRS2_ARCFU (O28853), 
KPRS_AERPE  (Q9YAW0), KPRS_COREF  (Q8FQV2), KPRS_CORGL  (Q8NRU9), 
KPRS_MYCBO  (P65233), KPRS_MYCLE  (Q9CD45), KPRS_MYCTO  (P9WKE2), 
KPRS_MYCTU  (P9WKE3), KPRS_NOSS1  (Q8YN97), KPRS_THEAC  (Q9HLV6), 
KPRS_THEVO  (Q97CA5), MACB_NITEU  (Q82VK1), PPR4_ARATH  (Q9FZ24), 
ROCO5_DICDI (Q1ZXD6), SPI1_SOLTU  (P58514), SPI2_SOLTU  (P58515), 
SPI4_SOLTU  (P58517), SPI5_SOLTU  (Q41484), SPI6_SOLTU  (Q41433), 
SPI7_SOLTU  (P30941), SPIKE_ADECT (Q65914), Y1519_RHILW (B5ZMI8), 
Y1668_ARATH (Q9C9N5), Y2074_RHIJ3 (Q1MHJ7), YCGA_BACSU  (P55908)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			86 PDB
			


			pdb_00001agx; pdb_00001djo; pdb_00001djp; pdb_00001hfj; pdb_00001hfk; pdb_00001hfw; pdb_00001hg0; pdb_00001hg1; pdb_00001ho3; pdb_00001ihd; pdb_00001jaz; pdb_00001jja; 
			
				pdb_00001jsl; pdb_00001jsr; pdb_00001nns; pdb_00001o7j; pdb_00001wsa; pdb_00001zq1; pdb_00002d6f; pdb_00002him; pdb_00002p2d; pdb_00002p2n; pdb_00002wlt; pdb_00002wt4; 
				pdb_00003eca; pdb_00003pga; pdb_00004pga; pdb_00005f52; pdb_00005hw0; pdb_00005i3z; pdb_00005i48; pdb_00005i4b; pdb_00005k3o; pdb_00005k45; pdb_00005k4g; pdb_00005k4h; 
				pdb_00005mq5; pdb_00005ot0; pdb_00006eok; pdb_00006nx6; pdb_00006nx7; pdb_00006nx8; pdb_00006nx9; pdb_00006nxa; pdb_00006nxb; pdb_00006nxc; pdb_00006nxd; pdb_00006pa2; 
				pdb_00006pa3; pdb_00006pa4; pdb_00006pa5; pdb_00006pa6; pdb_00006pa8; pdb_00006pab; pdb_00006pac; pdb_00006pae; pdb_00006rud; pdb_00006rue; pdb_00006ruf; pdb_00006syh; 
				pdb_00006uod; pdb_00006uog; pdb_00006uoh; pdb_00006v23; pdb_00006v24; pdb_00006v25; pdb_00006v26; pdb_00006v29; pdb_00006v2a; pdb_00006v2b; pdb_00006v5f; pdb_00006wyw; 
				pdb_00006wyx; pdb_00006wyy; pdb_00006wyz; pdb_00006wz4; pdb_00006wz6; pdb_00006wz8; pdb_00007m11; pdb_00007p9c; pdb_00007r57; pdb_00007r5q; pdb_00007u6m; pdb_00008ecd; 
				pdb_00008ece; pdb_00008wgq
			
			

			» more