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PROSITE entry PS00146


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PURL: https://purl.expasy.org/prosite/signature/PS00146

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General information about the entry

Entry name [info] BETA_LACTAMASE_A
Accession [info] PS00146
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00134
Associated ProRule [info] PRU10101

Name and characterization of the entry

Description [info] Beta-lactamase class-A active site.
Pattern [info] 
[FY]-x-[LIVMFY]-{E}-S-[TV]-x-K-x(3)-{T}-[AGLM]-{D}-{KA}-[LC].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 106 in 106 different sequences
Number of true positive hits 83 in 83 different sequences
Number of 'unknown' hits 2 in 2 different sequences
Number of false positive hits 21 in 21 different sequences
Number of false negative sequences 6
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 79.81 %
Recall (true positives / (true positives + false negatives)) 93.26 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 83 sequences 

BLA13_KLEPN (Q9S424), BLA1_ACTPL  (P67920), BLA1_AERHY  (Q44056), 

BLA1_BACCE  (P10424), BLA1_BACMY  (P28018), BLA1_ECOLX  (P0AD63), 
BLA1_ENTCL  (P18251), BLA1_HAEIF  (P67918), BLA1_KLEPN  (P0AD64), 
BLA1_MANHA  (P67919), BLA1_STRCI  (Q03680), BLA24_ECOLX (Q9S169), 
BLA29_KLEPN (Q9AHN9), BLA2_ECOLX  (P0A9Z7), BLA2_KLEPN  (P0A9Z8), 
BLA2_KLEPO  (P0A9Z9), BLA2_SALTM  (P0AA00), BLA2_STEMA  (P96465), 
BLA2_STRCI  (P14560), BLA34_ECOLX (Q93LM8), BLA3_BACCE  (P06548), 
BLA3_KLEPN  (P30896), BLA46_KLEOX (Q848S4), BLA4_KLEPN  (P37323), 
BLA5_KLEPN  (P0A3M1), BLA5_PSEAI  (P0A3M2), BLA6_KLEPN  (P96348), 
BLA8_ECOLX  (O08337), BLAB_PROVU  (P52664), BLAC_AMYLA  (Q06316), 
BLAC_BACAM  (Q44674), BLAC_BACCE  (P00809), BLAC_BACLI  (P00808), 
BLAC_BACSU  (P39824), BLAC_BACTU  (Q45726), BLAC_BACUN  (P30898), 
BLAC_CITKO  (P22390), BLAC_KITAU  (P10509), BLAC_KLEPN  (P05192), 
BLAC_MYCBO  (P0A5I7), BLAC_MYCTA  (A5U493), BLAC_MYCTO  (P9WKD2), 
BLAC_MYCTU  (P9WKD3), BLAC_NOCAS  (Q9EZQ7), BLAC_NOCFA  (Q5YXD6), 
BLAC_PHOVU  (P30899), BLAC_PROMI  (P30897), BLAC_PROVU  (P80298), 
BLAC_RHOCA  (P14171), BLAC_STAAU  (P00807), BLAC_STRAL  (P14559), 
BLAC_STRBA  (P35391), BLAC_STRCE  (Q06650), BLAC_STRLA  (P35393), 
BLAC_YEREN  (Q01166), BLAF_MYCFO  (Q59517), BLAT_ECOLX  (P62593), 
BLAT_KLEOX  (Q48406), BLAT_SALTI  (P62594), BLAV1_PSEAI (O87489), 
BLC14_ECOLX (A0A649V088), BLC15_ECO25 (A0A5R8T042), BLC1_ECOLX  (P28585), 
BLC25_ECOLX (Q8KSA6), BLC2_SALTM  (P74841), BLC3_PSEAI  (P37322), 
BLC4_PSEAI  (Q51355), BLC4_SALTM  (O33807), BLC5_SALTM  (O65975), 
BLC6_SALTM  (O65976), BLC6_VIBCL  (P81781), BLC8_CITAM  (Q9RMT4), 
BLC97_ECOLX (E1ANH6), BLE1_PSEAI  (P37321), BLML_ARTBC  (D4AXL1), 
BLO1_KLEOX  (P22391), BLO2_KLEOX  (P23954), BLP1_PSEAI  (Q03170), 
BLP4_PSEAI  (P16897), BLT1_ECOLX  (Q47066), BLT2_ECOLX  (O69395), 
ESTB_BURGA  (Q9KX40), FTSI_CAUVN  (B8H0A0)
» more

UniProtKB/Swiss-Prot
False negative sequences		 6 sequences 

BLAC_SERFO  (P80545), BLAC_STRFR  (P35392), BLAN_ENTCL  (P52663), 

BLAS1_SERMA (P52682), BLKPC_KLEOX (Q848S6), BLKPC_KLEPN (Q9F663)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

BLAC_STRGR  (P81173)


				
	

	

		UniProtKB/Swiss-Prot
'Unknown' sequences		
		
			2 sequences
			


			
FIMDD_DICNO (P17420), FIMDH_DICNO (P17421)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			21 sequences
			


			
GLSA2_YERPE (Q9ZC49), GLSA_SYNY3  (P73903), MYO7B_MOUSE (Q99MZ6), 

			
NRT25_ARATH (Q9LPV5), PCRK1_ARATH (Q9SF86), PCRK2_ARATH (Q9LZF8), 
PH11A_MOUSE (Q8BVM9), PH11L_RAT   (Q5I0J8), PHF11_MOUSE (A6H5X4), 
PHF11_RAT   (Q5I0E2), PHF1_ARATH  (Q8GYE0), PORA_PHOPM  (B5CY96), 
PP244_ARATH (Q9LT48), PP448_ARATH (Q9FJY9), PPR83_ARATH (Q9FXA9), 
RR2_EUGGR   (P30389), RSMH_MESFL  (Q6F170), SRP72_DICDI (Q54EP7), 
UTP17_SCHPO (O13878), Y0701_DICDI (Q559T8), Y2899_ARATH (O81069)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			281 PDB
			


			pdb_00001alq; pdb_00001axb; pdb_00001blc; pdb_00001blh; pdb_00001blp; pdb_00001bsg; pdb_00001bt5; pdb_00001btl; pdb_00001bza; pdb_00001ci8; pdb_00001ci9; pdb_00001ck3; 
			
				pdb_00001e25; pdb_00001erm; pdb_00001ero; pdb_00001erq; pdb_00001esu; pdb_00001fqg; pdb_00001g68; pdb_00001g6a; pdb_00001ghi; pdb_00001ghm; pdb_00001ghp; pdb_00001hzo; 
				pdb_00001i2s; pdb_00001i2w; pdb_00001iyo; pdb_00001iyp; pdb_00001iyq; pdb_00001iys; pdb_00001jtd; pdb_00001jtg; pdb_00001jvj; pdb_00001jwp; pdb_00001jwv; pdb_00001jwz; 
				pdb_00001kge; pdb_00001kgf; pdb_00001kgg; pdb_00001lhy; pdb_00001li0; pdb_00001li9; pdb_00001m40; pdb_00001mbl; pdb_00001n9b; pdb_00001nxy; pdb_00001ny0; pdb_00001nym; 
				pdb_00001nyy; pdb_00001ome; pdb_00001ong; pdb_00001pio; pdb_00001pzo; pdb_00001pzp; pdb_00001q2p; pdb_00001rcj; pdb_00001s0w; pdb_00001shv; pdb_00001tdg; pdb_00001tdl; 
				pdb_00001tem; pdb_00001vm1; pdb_00001w7f; pdb_00001we4; pdb_00001xpb; pdb_00001xxm; pdb_00001yt4; pdb_00001zg4; pdb_00002a3u; pdb_00002a49; pdb_00002b5r; pdb_00002blm; 
				pdb_00002cc1; pdb_00002g2u; pdb_00002g2w; pdb_00002gdn; pdb_00002h0t; pdb_00002h0y; pdb_00002h10; pdb_00002h5s; pdb_00002v1z; pdb_00002v20; pdb_00002wk0; pdb_00002wyx; 
				pdb_00002xqz; pdb_00002xr0; pdb_00002y91; pdb_00002zd8; pdb_00002zq7; pdb_00002zq8; pdb_00002zq9; pdb_00002zqa; pdb_00002zqc; pdb_00002zqd; pdb_00003b3x; pdb_00003blm; 
				pdb_00003byd; pdb_00003c4o; pdb_00003c4p; pdb_00003c7u; pdb_00003c7v; pdb_00003cg5; pdb_00003cmz; pdb_00003d4f; pdb_00003dtm; pdb_00003dwz; pdb_00003iqa; pdb_00003jyi; 
				pdb_00003ly3; pdb_00003ly4; pdb_00003m2j; pdb_00003m2k; pdb_00003m6b; pdb_00003m6h; pdb_00003mke; pdb_00003mkf; pdb_00003mxr; pdb_00003mxs; pdb_00003n4i; pdb_00003n6i; 
				pdb_00003n7w; pdb_00003n8l; pdb_00003n8r; pdb_00003n8s; pdb_00003nbl; pdb_00003nc8; pdb_00003nck; pdb_00003nde; pdb_00003ndg; pdb_00003oph; pdb_00003opl; pdb_00003opp; 
				pdb_00003opr; pdb_00003sh7; pdb_00003sh8; pdb_00003sh9; pdb_00003soi; pdb_00003toi; pdb_00003v50; pdb_00003v5m; pdb_00003vff; pdb_00003vfh; pdb_00003zhh; pdb_00004bd0; 
				pdb_00004bd1; pdb_00004blm; pdb_00004c3q; pdb_00004df6; pdb_00004dxb; pdb_00004dxc; pdb_00004ebl; pdb_00004ebn; pdb_00004ebp; pdb_00004fcf; pdb_00004fh4; pdb_00004gd6; 
				pdb_00004gd8; pdb_00004gdb; pdb_00004gku; pdb_00004hbt; pdb_00004hbu; pdb_00004ibr; pdb_00004ibx; pdb_00004id4; pdb_00004jlf; pdb_00004jpm; pdb_00004m3k; pdb_00004mbf; 
				pdb_00004mbh; pdb_00004mbk; pdb_00004mez; pdb_00004n1h; pdb_00004n92; pdb_00004n9k; pdb_00004n9l; pdb_00004q8i; pdb_00004qhc; pdb_00004qy5; pdb_00004qy6; pdb_00004r3b; 
				pdb_00004r4r; pdb_00004r4s; pdb_00004rva; pdb_00004rx2; pdb_00004x69; pdb_00004x6t; pdb_00004zam; pdb_00004zj1; pdb_00005a90; pdb_00005a91; pdb_00005a92; pdb_00005a93; 
				pdb_00005ee8; pdb_00005fa7; pdb_00005fao; pdb_00005fap; pdb_00005g18; pdb_00005ghx; pdb_00005ghy; pdb_00005ghz; pdb_00005hvi; pdb_00005hw1; pdb_00005hw5; pdb_00005i52; 
				pdb_00005i63; pdb_00005iq8; pdb_00005kkf; pdb_00005kmw; pdb_00005kpu; pdb_00005ksc; pdb_00005lwf; pdb_00005nj2; pdb_00005npo; pdb_00005oyo; pdb_00005zfl; pdb_00005zft; 
				pdb_00005zg6; pdb_00006apa; pdb_00006ayk; pdb_00006b2n; pdb_00006b5x; pdb_00006b5y; pdb_00006b68; pdb_00006b69; pdb_00006b6a; pdb_00006b6b; pdb_00006b6c; pdb_00006b6d; 
				pdb_00006b6e; pdb_00006b6f; pdb_00006n14; pdb_00006u58; pdb_00006w2z; pdb_00006wgr; pdb_00007a5t; pdb_00007a5u; pdb_00007a5w; pdb_00007a6z; pdb_00007a71; pdb_00007a72; 
				pdb_00007a74; pdb_00007k8e; pdb_00007k8f; pdb_00007k8h; pdb_00007k8k; pdb_00007k8l; pdb_00007qlp; pdb_00007qnk; pdb_00007qor; pdb_00007u48; pdb_00007u49; pdb_00007u4b; 
				pdb_00007u57; pdb_00008btu; pdb_00008btv; pdb_00008btw; pdb_00008bv4; pdb_00008ddz; pdb_00008de0; pdb_00008de1; pdb_00008de2; pdb_00008ebi; pdb_00008ebr; pdb_00008ec4; 
				pdb_00008ecf; pdb_00008gcs; pdb_00008gct; pdb_00008gcv; pdb_00008gcx; pdb_00008iwv; pdb_00008ix8; pdb_00008ixx; pdb_00008iy4; pdb_00008j6y; pdb_00008oe1; pdb_00008oe5; 
				pdb_00008r88; pdb_00008rfz; pdb_00008rg2; pdb_00008rii; pdb_00008sj3
			
			

			» more