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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE entry PS00188


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PURL: https://purl.expasy.org/prosite/signature/PS00188

Direct ScanProsite submission
General information about the entry

Entry name [info] BIOTIN
Accession [info] PS00188
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2001 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00167

Name and characterization of the entry

Description [info] Biotin-requiring enzymes attachment site.
Pattern [info] 
[GDN]-[DEQTR]-x-[LIVMFY]-x(2)-[LIVM]-x-[AIV]-M-K-[LVMAT]-x(3)-[LIVM]-x-
[SAV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 81 in 81 different sequences
Number of true positive hits 81 in 81 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 13
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 86.17 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] biotin at position 10
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 81 sequences 

2OCL_HYDTT  (D3DJ41), ACACA_BOVIN (Q9TTS3), ACACA_HUMAN (Q13085), 

ACACA_MOUSE (Q5SWU9), ACACA_RAT   (P11497), ACACA_SHEEP (Q28559), 
ACAC_CHICK  (P11029), ACAC_DICDI  (Q54J08), ACAC_SCHPO  (P78820), 
ACAC_YEAST  (Q00955), ACC1_ARATH  (Q38970), ACC2_ARATH  (F4I1L3), 
ACCA1_MYCBO (P0A509), ACCA1_MYCTO (P9WPQ2), ACCA1_MYCTU (P9WPQ3), 
ACCA3_MYCLE (P46392), ACCA3_MYCTU (P96890), BCCP1_ARATH (Q42533), 
BCCP2_ARATH (Q9LLC1), BCCP_BACSU  (P49786), BCCP_CHLMU  (Q9PKR5), 
BCCP_CHLPN  (Q9Z901), BCCP_CHLTR  (O84125), BCCP_CYACA  (O19918), 
BCCP_ECO57  (P0ABE0), BCCP_ECOL6  (P0ABD9), BCCP_ECOLI  (P0ABD8), 
BCCP_HAEIN  (P43874), BCCP_NOSS1  (Q06881), BCCP_PORPU  (P51283), 
BCCP_PROFR  (P02904), BCCP_PSEAE  (P37799), BCCP_PYRYE  (Q1XDK5), 
BCCP_SHIFL  (P0ABE1), BCCP_SOLLC  (P05115), BCCP_SOYBN  (Q42783), 
BCCP_STRMU  (P29337), BCCP_STRP6  (Q5XAE6), DCOA_KLEPN  (P13187), 
DCOA_SALTI  (Q8XGX8), DCOA_SALTY  (Q03030), DMXL1_CRYX8 (A0A4P8DJE6), 
DUR1_LACKL  (A5H0J2), DUR1_YEAST  (P32528), GCDC_ACIFV  (Q9ZAA7), 
HFA1_YEAS1  (B3LM95), HFA1_YEAS2  (C7GRE4), HFA1_YEAS7  (A6ZMR9), 
HFA1_YEAS8  (C8ZF72), HFA1_YEAST  (P32874), LAMA_EMENI  (P38095), 
MCCA_ARATH  (Q42523), MCCA_DICDI  (Q54KE6), MCCA_HUMAN  (Q96RQ3), 
MCCA_MOUSE  (Q99MR8), MCCA_ORYSJ  (Q2QMG2), MCCA_RAT(Q5I0C3), 
MCCA_SOYBN  (Q42777), MMDC_PROMO  (O54030), MMDC_VEIPA  (Q57111), 
PCCA_CAEBR  (Q612F5), PCCA_CAEEL  (Q19842), PCCA_HALMT  (I3R7G3), 
PCCA_HUMAN  (P05165), PCCA_MOUSE  (Q91ZA3), PCCA_PIG(P0DTA4), 
PCCA_RAT(P14882), PCCA_RUEPO  (Q5LUF3), PYC1_YEAST  (P11154), 
PYC2_YEAST  (P32327), PYCB_METJA  (Q58628), PYC_ASPNG   (Q9HES8), 
PYC_ASPTE   (O93918), PYC_ASPTN   (Q0CLK1), PYC_BOVIN   (Q29RK2), 
PYC_HUMAN   (P11498), PYC_MOUSE   (Q05920), PYC_PICAN   (Q8X1T3), 
PYC_PICPA   (P78992), PYC_RAT (P52873), PYC_SCHPO   (Q9UUE1)
» more

UniProtKB/Swiss-Prot
False negative sequences		 13 sequences 

ACACB_HUMAN (O00763), ACC1_ORYSJ  (Q8S6N5), ACC2_ORYSJ  (B9FK36), 

BLAP_BACSU  (C0H419), BTB7_MYCBO  (P0A511), BTB7_MYCLE  (Q9CCH9), 
BTB7_MYCS2  (Q9XCD6), BTB7_MYCTO  (P9WPQ0), BTB7_MYCTU  (P9WPQ1), 
MADF_MALRU  (O06930), PYC1_CAEEL  (O17732), PYCB_METTH  (O27179), 
PYC_BACSU   (Q9KWU4)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

PCCA_MYXXA  (P81185)


				
	

	

		PDB
[Detailed view]		
		
			51 PDB
			


			pdb_00001a6x; pdb_00001bdo; pdb_00001dcz; pdb_00001dd2; pdb_00001o78; pdb_00002bdo; pdb_00002ejm; pdb_00002jku; pdb_00003bdo; pdb_00003bg3; pdb_00003bg9; pdb_00003n6r; 
			
				pdb_00004hr7; pdb_00005csa; pdb_00005csk; pdb_00005csl; pdb_00005mlk; pdb_00006g2d; pdb_00006g2h; pdb_00006g2i; pdb_00006roj; pdb_00007wta; pdb_00007wtb; pdb_00007wtc; 
				pdb_00007wtd; pdb_00007wte; pdb_00007ybu; pdb_00008hwl; pdb_00008j4z; pdb_00008j78; pdb_00008j7d; pdb_00008j7o; pdb_00008j99; pdb_00008jak; pdb_00008jaw; pdb_00008jxl; 
				pdb_00008jxm; pdb_00008jxn; pdb_00008k2v; pdb_00008uz2; pdb_00008xkz; pdb_00008xl0; pdb_00008xl1; pdb_00008xl2; pdb_00008xl3; pdb_00008xl4; pdb_00008xl5; pdb_00008xl6; 
				pdb_00008xl7; pdb_00008xl8; pdb_00008xl9
			
			

			» more