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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00223


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PURL: https://purl.expasy.org/prosite/signature/PS00223

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General information about the entry

Entry name [info] ANNEXIN_1
Accession [info] PS00223
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00195

Name and characterization of the entry

Description [info] Annexin repeat signature.
Pattern [info] 
[TG]-[STV]-x(8)-[LIVMF]-x(2)-R-x(3)-[DEQNH]-x(2)-{S}-x(4)-[IFY]-x(7)-
[LIVMF]-x(3)-[LIVMF]-x(5)-{I}-x(5)-[LIVMFA]-x(2)-[LIVMF].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 319 in 100 different sequences
Number of true positive hits 310 in 91 different sequences
Number of 'unknown' hits 0
Number of false positive hits 9 in 9 different sequences
Number of false negative sequences 3
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 97.18 %
Recall (true positives / (true positives + false negatives)) 99.04 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 8
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 91 sequences 

ANX10_DROME (P22465), ANX10_HUMAN (Q9UJ72), ANX10_MOUSE (Q9QZ10), 

ANX11_BOVIN (P27214), ANX11_COLLI (P14950), ANX11_DROME (Q9VXG4), 
ANX11_HUMAN (P50995), ANX11_MOUSE (P97384), ANX11_RABIT (P33477), 
ANX12_COLLI (Q92040), ANX12_HYDVU (P26256), ANX13_CANLF (Q29471), 
ANX13_HUMAN (P27216), ANX13_MOUSE (Q99JG3), ANX13_SCHJA (C1L7Y4), 
ANX1_GOSHI  (P93157), ANX22_SCHMA (C4QH88), ANX2A_XENLA (P27006), 
ANX2B_XENLA (P24801), ANX4_FRAAN  (P51074), ANXA1_BOVIN (P46193), 
ANXA1_CAVCU (P14087), ANXA1_CHICK (Q92108), ANXA1_HORSE (Q8HZM6), 
ANXA1_HUMAN (P04083), ANXA1_MOUSE (P10107), ANXA1_PANTR (A5A6M2), 
ANXA1_PIG   (P19619), ANXA1_PONAB (Q5REL2), ANXA1_RABIT (P51662), 
ANXA1_RAT   (P07150), ANXA1_RODSP (P24551), ANXA2_BOVIN (P04272), 
ANXA2_CANLF (Q6TEQ7), ANXA2_CEREL (Q2Q1M6), ANXA2_CHICK (P17785), 
ANXA2_HUMAN (P07355), ANXA2_MOUSE (P07356), ANXA2_PIG   (P19620), 
ANXA2_PONAB (Q5R5A0), ANXA2_RAT   (Q07936), ANXA2_SHEEP (A2SW69), 
ANXA3_BOVIN (Q3SWX7), ANXA3_HUMAN (P12429), ANXA3_MOUSE (O35639), 
ANXA3_RAT   (P14669), ANXA4_BOVIN (P13214), ANXA4_CANLF (P50994), 
ANXA4_HUMAN (P09525), ANXA4_MOUSE (P97429), ANXA4_PIG   (P08132), 
ANXA4_RAT   (P55260), ANXA5_BOVIN (P81287), ANXA5_CHICK (P17153), 
ANXA5_CYNPY (P70075), ANXA5_HUMAN (P08758), ANXA5_MACFA (Q4R4H7), 
ANXA5_MOUSE (P48036), ANXA5_PANTR (Q5R1W0), ANXA5_RAT   (P14668), 
ANXA6_BOVIN (P79134), ANXA6_CHICK (P51901), ANXA6_HUMAN (P08133), 
ANXA6_MOUSE (P14824), ANXA6_RAT   (P48037), ANXA7_BOVIN (P20072), 
ANXA7_DICDI (P24639), ANXA7_HUMAN (P20073), ANXA7_MACFA (Q4R5L5), 
ANXA7_MOUSE (Q07076), ANXA7_XENLA (Q92125), ANXA8_BOVIN (Q95L54), 
ANXA8_HUMAN (P13928), ANXA8_MOUSE (O35640), ANXA8_PANTR (A5A6L7), 
ANXA8_RABIT (O97529), ANXA8_RAT   (Q4FZU6), ANXA9_BOVIN (Q3ZC08), 
ANXA9_HUMAN (O76027), ANXA9_MOUSE (Q9JHQ0), ANXB9_DROME (P22464), 
ANXC1_CRYNH (J9VS56), ANXD1_ARATH (Q9SYT0), ANXD2_ARATH (Q9XEE2), 
ANXD3_ARATH (Q9SE45), ANXD5_ARATH (Q9C9X3), ANXD6_ARATH (Q9LX08), 
ANXD7_ARATH (Q9LX07), ANXD8_ARATH (Q94CK4), AXA2L_HUMAN (A6NMY6), 
AXA81_HUMAN (Q5VT79)
» more

UniProtKB/Swiss-Prot
False negative sequences		 3 sequences 

ANXA2_MESAU (C0HJG9), ANXD4_ARATH (Q9ZVJ6), ANXE1_GIAIN (Q9NFS4)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			1 sequence
			


			
ANXA6_RABIT (Q9TS53)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			9 sequences
			


			
ATP6_ACTP2  (A3N2V0), ATP6_ACTP7  (B3H2P9), ATP6_ACTPJ  (B0BRX8), 

			
ATP6_HAEDU  (Q7VPP6), CBPQ_MOUSE  (Q9WVJ3), CBPQ_RAT(Q6IRK9), 
DOX1_PERHD  (W0FKI0), PLSP2_LOTGI (B3A0P3), RPOB_BDEBA  (Q6MJ09)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			103 PDB
			


			pdb_00001a8a; pdb_00001a8b; pdb_00001aei; pdb_00001aii; pdb_00001ain; pdb_00001ala; pdb_00001ann; pdb_00001anw; pdb_00001anx; pdb_00001aow; pdb_00001avc; pdb_00001avh; 
			
				pdb_00001avr; pdb_00001axn; pdb_00001bc0; pdb_00001bc1; pdb_00001bc3; pdb_00001bcw; pdb_00001bcy; pdb_00001bcz; pdb_00001bo9; pdb_00001dm5; pdb_00001g5n; pdb_00001hak; 
				pdb_00001hm6; pdb_00001hvd; pdb_00001hve; pdb_00001hvf; pdb_00001hvg; pdb_00001i4a; pdb_00001m9i; pdb_00001mcx; pdb_00001n00; pdb_00001n41; pdb_00001n42; pdb_00001n44; 
				pdb_00001sav; pdb_00001w3w; pdb_00001w45; pdb_00001w7b; pdb_00001xjl; pdb_00001ycn; pdb_00001yii; pdb_00001yj0; pdb_00002h0k; pdb_00002h0l; pdb_00002h0m; pdb_00002hyu; 
				pdb_00002hyv; pdb_00002hyw; pdb_00002ie6; pdb_00002ie7; pdb_00002q4c; pdb_00002ran; pdb_00002xo2; pdb_00002xo3; pdb_00002zhi; pdb_00002zhj; pdb_00002zoc; pdb_00003brx; 
				pdb_00004hre; pdb_00004mdu; pdb_00004mdv; pdb_00004x9p; pdb_00005lpu; pdb_00005lpx; pdb_00005lq0; pdb_00005lq2; pdb_00005n7d; pdb_00005n7f; pdb_00005n7g; pdb_00006b3i; 
				pdb_00006k22; pdb_00006k25; pdb_00006twq; pdb_00006twu; pdb_00006twx; pdb_00006twy; pdb_00007dto; pdb_00007eq7; pdb_00007nmi; pdb_00007p70; pdb_00007p71; pdb_00007p72; 
				pdb_00007p73; pdb_00007p74; pdb_00007pc3; pdb_00007pc4; pdb_00007pc5; pdb_00007pc7; pdb_00007pc8; pdb_00007pc9; pdb_00007pcb; pdb_00007qql; pdb_00007qqm; pdb_00007qqn; 
				pdb_00007zvn; pdb_00007zvx; pdb_00008ael; pdb_00008gyc; pdb_00008h0j; pdb_00008h9z; pdb_00008w5s
			
			

			» more