|PROSITE documentation PDOC00241 [for PROSITE entry PS00268]|
Cecropins [1,2,3] are potent antibacterial proteins that constitute a main part of the cell-free immunity of insects. Cecropins are small proteins of about 35 amino acid residues active against both Gram-positive and Gram-negative bacteria. They seem to exert a lytic action on bacterial membranes.
Cecropins isolated from insects other than Cecropia have been given various names: bactericidin, lepidopteran, sarcotoxin, etc. All of these peptides are structurally related. Cecropin P1, an intestinal antibacterial peptide from pig, also belongs to this family.
As a signature pattern for this family of active peptides, we selected a conserved region in the N-terminal section of cecropins.Last update:
April 2006 / Pattern revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Boman H.G., Hultmark D.|
|Title||Cell-free immunity in insects.|
|Source||Annu. Rev. Microbiol. 41:103-126(1987).|
|Title||Antibacterial peptides: key components needed in immunity.|
|3||Authors||Boman H.G., Faye I., Gudmundsson G.H., Lee J.-Y., Lidholm D.A.|
|Title||Cell-free immunity in Cecropia. A model system for antibacterial proteins.|
|Source||Eur. J. Biochem. 201:23-31(1991).|