We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE entry PS00347
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PURL: https://purl.expasy.org/prosite/signature/PS00347
Direct ScanProsite submission
General information about the entry
| Entry name [info] | ZF_PARP_1 |
| Accession [info] | PS00347 |
| Entry type [info] | PATTERN |
| Date [info] |
01-NOV-1990 CREATED;
01-APR-2006 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00360 |
Name and characterization of the entry
| Description [info] | Zinc finger poly(ADP-ribose) polymerase (PARP)-type signature. |
| Pattern [info] |
C-[KR]-x-C-x(3)-I-x-[KAL]-x(3)-[RG]-x(16,18)-W-[FYH]-H-x(2)-C. |
Numerical results [info]
| Total number of hits | 21 in 13 different sequences |
| Number of true positive hits | 21 in 13 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 6 |
| Number of 'partial' sequences | 1 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 77.78 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 2 |
| Site [info] | zinc(?) at position 1 |
| Site [info] | zinc(?) at position 4 |
| Site [info] | zinc(?) at position 14 |
| Site [info] | zinc(?) at position 16 |
| Version [info] | 2 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
13 sequences
DNLI3_HUMAN (P49916), DNLI3_MOUSE (P97386), PARP1_BOVIN (P18493), PARP1_CAEEL (Q9N4H4), PARP1_CHICK (P26446), PARP1_CRIGR (Q9R152), PARP1_DANRE (Q5RHR0), PARP1_HUMAN (P09874), PARP1_MOUSE (P11103), PARP1_RAT (P27008), PARP1_XENLA (P31669), PARP_DROME (P35875), PARP_SARPE (Q11208)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
6 sequences
PARP1_ARATH (Q9ZP54), PARP1_MAIZE (Q9ZSV1), PARP1_ORYSJ (Q7EYV7), YEU7_SCHPO (O13706), YGI7_SCHPO (Q9Y7K9), ZDP_ARATH (Q84JE8)» more |
| UniProtKB/Swiss-Prot 'Partial' sequences |
1 sequence
PARP1_ONCMA (Q08824) |
| PDB [Detailed view] |
20 PDB
pdb_00001uw0; pdb_00002cs2; pdb_00002dmj; pdb_00002l30; pdb_00002l31; pdb_00002n8a; pdb_00003od8; pdb_00003oda; pdb_00003odc; pdb_00003ode; pdb_00004av1; pdb_00004dqy; pdb_00004opx; pdb_00004oqa; pdb_00004oqb; pdb_00007s68; pdb_00007s6h; pdb_00007s6m; pdb_00007s81; pdb_00008g0h » more |