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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00356


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PURL: https://purl.expasy.org/prosite/signature/PS00356

Direct ScanProsite submission
General information about the entry

Entry name [info] HTH_LACI_1
Accession [info] PS00356
Entry type [info] PATTERN
Date [info] 01-NOV-1990 CREATED;
01-NOV-1995 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00366

Name and characterization of the entry

Description [info] LacI-type HTH domain signature.
Pattern [info] 
[LIVM]-x-[DE]-[LIVM]-A-x(2)-[STAGV]-x-V-[GSTP]-x(2)-[STAG]-[LIVMA]-x(2)-
[LIVMFYAN]-[LIVMC].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 185 in 185 different sequences
Number of true positive hits 179 in 179 different sequences
Number of 'unknown' hits 0
Number of false positive hits 6 in 6 different sequences
Number of false negative sequences 13
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 96.76 %
Recall (true positives / (true positives + false negatives)) 93.23 %

Comments [info]

Taxonomic range [info] Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 179 sequences 

ASCG_ECOLI  (P24242), CCPA_BACSU  (P25144), CCPA_PRIMG  (P46828), 

CCPA_STAAC  (Q5HF38), CCPA_STAAM  (P67655), CCPA_STAAN  (P99175), 
CCPA_STAAR  (Q6GFX2), CCPA_STAAS  (Q6G8J1), CCPA_STAAW  (Q8NW33), 
CCPA_STAEQ  (Q5HNH3), CCPA_STAES  (Q8CNV8), CCPA_STAXY  (Q56194), 
CCPA_STRMU  (O07329), CCPB_BACSU  (P37517), CRA_ECO57   (P0ACP3), 
CRA_ECOL6   (P0ACP2), CRA_ECOLI   (P0ACP1), CRA_SALTI   (P0A2P9), 
CRA_SALTY   (P0A2P8), CRA_SHIFL   (P0ACP4), CSCR_ECOLX  (P62604), 
CSCR_SHIFL  (P62572), CYTR_ECO57  (P0ACN9), CYTR_ECOL6  (P0ACN8), 
CYTR_ECOLI  (P0ACN7), CYTR_SHIFL  (P0ACP0), DEGA_BACSU  (P37947), 
EBGR_ECOLI  (P06846), ENDR_PAEPO  (P27871), EXUR_BACSU  (Q9JMQ1), 
FRUR_VIBCH  (Q9KM69), GALR_ECOLI  (P03024), GALR_HAEIN  (P31766), 
GALR_LACCA  (O84905), GALR_SALTS  (E1WAQ4), GALR_SALTY  (P0CL11), 
GALR_STRTR  (Q9ZB11), GALS_ECOLI  (P25748), GALS_SALTY  (P41030), 
GLK_BURL3   (Q39IQ1), GLK_BURO1   (Q1BYA7), GLK_BURP1   (Q3JPP0), 
GLK_BURPS   (Q63RQ7), GLK_BURTA   (Q2SYA5), GLK_PARXL   (Q143F8), 
GNTR_ECOL6  (P0ACP6), GNTR_ECOLI  (P0ACP5), GNTR_PSEAE  (Q9I1F6), 
IDNR_ECOLI  (P39343), IRRE_DEIDV  (C1CZ84), IRRE_DEIRA  (Q9RXY7), 
KDGR_BACSU  (P50844), LACI_ECOLI  (P03023), LACI_KLEPN  (P06220), 
MALI_ECOLI  (P18811), MALI_VIBFU  (P96158), MALR_CLOBU  (O05103), 
MALR_STAXY  (Q56201), MALR_STRCO  (P72396), MALR_STRPN  (P0A4T1), 
MALR_STRR6  (P0A4T2), MELR_BACSU  (O34829), NFXB_PSEAE  (P32265), 
PEPR_LACDL  (Q48544), PTXS_PSEDL  (A0A167V873), PTXS_PSEPK  (Q88HH7), 
PURR_ACTP2  (A3N0H9), PURR_ACTP7  (B3H1F6), PURR_ACTPJ  (B0BP99), 
PURR_ACTSZ  (A6VNL0), PURR_ALIF1  (Q5E4H9), PURR_ALIFM  (B5FF00), 
PURR_ALISL  (B6EH86), PURR_CROS8  (A7MFD3), PURR_ECO24  (A7ZMC4), 
PURR_ECO27  (B7URZ9), PURR_ECO45  (B7MA12), PURR_ECO55  (B7L5L1), 
PURR_ECO57  (P0ACP8), PURR_ECO5E  (B5Z492), PURR_ECO7I  (B7NTX5), 
PURR_ECO81  (B7MVD4), PURR_ECO8A  (B7M0L5), PURR_ECOBW  (C4ZYC2), 
PURR_ECOHS  (A8A0K5), PURR_ECOK1  (A1ABJ9), PURR_ECOL5  (Q0THG9), 
PURR_ECOL6  (Q8FH72), PURR_ECOLC  (B1IQ96), PURR_ECOLI  (P0ACP7), 
PURR_ECOLU  (B7NBB1), PURR_ECOSE  (B6IB98), PURR_ECOSM  (B1LEM6), 
PURR_ECOUT  (Q1RBD7), PURR_EDWI9  (C5BE45), PURR_ERWT9  (B2VEM5), 
PURR_ESCF3  (B7LQA9), PURR_GLAP5  (B8F4D0), PURR_HAEDU  (Q7VL44), 
PURR_HAEI8  (Q4QL70), PURR_HAEIE  (A5UCM9), PURR_HAEIG  (A5UIZ0), 
PURR_HAEIN  (P46456), PURR_HISS1  (Q0I4B4), PURR_HISS2  (B0UUN7), 
PURR_KLEP3  (B5XWL8), PURR_KLEP7  (A6TA06), PURR_MANSM  (Q65TP0), 
PURR_PASMU  (Q9CN88), PURR_PECAS  (Q6D5W3), PURR_PECCP  (C6DK36), 
PURR_PHOLL  (Q7N3V8), PURR_PHOPR  (Q6LQB9), PURR_PROMH  (B4EWM9), 
PURR_SALA4  (B5F6L7), PURR_SALAR  (A9MEJ1), PURR_SALCH  (Q57PK6), 
PURR_SALDC  (B5FIH3), PURR_SALEP  (B5QV29), PURR_SALG2  (B5RAM9), 
PURR_SALHS  (B4TH70), PURR_SALNS  (B4T567), PURR_SALPA  (Q5PH15), 
PURR_SALPB  (A9N0Y2), PURR_SALPC  (C0Q5V2), PURR_SALPK  (B5BKD9), 
PURR_SALSV  (B4TUY8), PURR_SALTI  (Q8Z6P1), PURR_SALTY  (O68446), 
PURR_SERP5  (A8GDV6), PURR_SHIB3  (B2U2G3), PURR_SHIBS  (Q321B7), 
PURR_SHIDS  (Q32FB3), PURR_SHIF8  (Q0T4B4), PURR_SHIFL  (P0ACP9), 
PURR_SHISS  (Q3Z213), PURR_VIBA3  (B7VMG4), PURR_VIBC1  (A7N1L2), 
PURR_VIBC3  (A5F7H0), PURR_VIBCH  (Q9KRC1), PURR_VIBCM  (C3LN44), 
PURR_VIBPA  (Q87QW9), PURR_VIBVU  (Q8DAQ5), PURR_VIBVY  (Q7MJ57), 
PURR_YERE8  (A1JP52), PURR_YERP3  (A7FHK2), PURR_YERPA  (Q1C774), 
PURR_YERPB  (B2K5I4), PURR_YERPE  (Q7CIS2), PURR_YERPG  (A9QZB3), 
PURR_YERPN  (Q1CIL0), PURR_YERPP  (A4TIQ4), PURR_YERPS  (Q66A32), 
PURR_YERPY  (B1JJ59), RBSR_BACSU  (P36944), RBSR_ECO57  (P0ACQ2), 
RBSR_ECOL6  (P0ACQ1), RBSR_ECOLI  (P0ACQ0), RBSR_HAEIN  (P44329), 
RBSR_HALH5  (Q9K6K2), RBSR_PASMU  (Q9CPA2), RBSR_SHIFL  (P0ACQ3), 
RBTR_KLEAE  (P07760), REG1_STRLI  (P72469), REGA_CLOAB  (P58258), 
REGA_CLOSA  (Q45831), SACR_LACLL  (Q04939), SCRR_KLEPN  (P37076), 
SCRR_PEDPE  (P43472), SCRR_SALTM  (P37077), SCRR_STAXY  (P74892), 
SCRR_STRMU  (Q54430), SCRR_VIBAL  (P24508), TRER_ECOLI  (P36673), 
TRER_SALTY  (P36674), YAML_STRLM  (P23823), YCJW_ECOLI  (P77615), 
YKVZ_BACSU  (O31690), YVDE_BACSU  (O06987)
» more

UniProtKB/Swiss-Prot
False negative sequences		 13 sequences 

AGLR_RHIME  (Q9Z3R4), CELR_THEFU  (O87590), GANR_BACSU  (O07008), 

IPSA_CORGL  (Q8NMF0), LACR_LACHE  (Q7WTB0), NTDR_BACSU  (O07567), 
PECTR_LACP7 (A9KNI6), PTXS_PSEAE  (G3XD97), R3575_MYCS2 (A0R530), 
R3575_MYCTU (P96857), RAFR_ECOLX  (P21867), RBSR_LACLA  (Q9CF41), 
Y4158_STRCO (Q05954)
» more

UniProtKB/Swiss-Prot
False positive sequences		 6 sequences 

LOGH_MYCMM  (B2HS63), MDH_BACTN   (Q8A0W0), RPOB_CHRFK  (A0M3Y9), 

S29A3_BOVIN (A1A4N1), Y1018_STRA3 (P67251), Y983_STRA5  (P67252)
» more

PDB
[Detailed view]		 61 PDB

pdb_00001bdh; pdb_00001bdi; pdb_00001cjg; pdb_00001efa; pdb_00001jfs; pdb_00001jft; pdb_00001jh9; pdb_00001jwl; pdb_00001jye; pdb_00001jyf; pdb_00001l1m; pdb_00001lbg; pdb_00001lbh; pdb_00001lbi; pdb_00001lcc; pdb_00001lcd; pdb_00001lqc; pdb_00001osl; pdb_00001pnr; pdb_00001pru; pdb_00001prv; pdb_00001qp0; pdb_00001qp4; pdb_00001qp7; pdb_00001qpz; pdb_00001qqa; pdb_00001qqb; pdb_00001rzr; pdb_00001uxc; pdb_00001uxd; pdb_00001vpw; pdb_00001wet; pdb_00001zay; pdb_00001zvv; pdb_00002bjc; pdb_00002hsg; pdb_00002jcg; pdb_00002kei; pdb_00002kej; pdb_00002kek; pdb_00002lcv; pdb_00002pe5; pdb_00002pua; pdb_00002pub; pdb_00002puc; pdb_00002pud; pdb_00002pue; pdb_00002puf; pdb_00002pug; pdb_00003dbi; pdb_00003dte; pdb_00003dti; pdb_00003dtk; pdb_00003edc; pdb_00003oqm; pdb_00003oqn; pdb_00003oqo; pdb_00004rzs; pdb_00004rzt; pdb_00007e5w; pdb_00007x7h
» more