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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE entry PS00392


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PURL: https://purl.expasy.org/prosite/signature/PS00392

Direct ScanProsite submission
General information about the entry

Entry name [info] DDC_GAD_HDC_YDC
Accession [info] PS00392
Entry type [info] PATTERN
Date [info] 01-NOV-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00329

Name and characterization of the entry

Description [info] DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site.
Pattern [info] 
S-[LIVMFYW]-x-{KG}-x(3)-K-[LIVMFYWGH]-[LIVMFYWG]-x-{R}-x-[LIVMFYW]-{V}-
[CA]-x(2)-[LIVMFYWQ]-{K}-x-[RK].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 119 in 119 different sequences
Number of true positive hits 109 in 109 different sequences
Number of 'unknown' hits 0
Number of false positive hits 10 in 10 different sequences
Number of false negative sequences 47
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 91.60 %
Recall (true positives / (true positives + false negatives)) 69.87 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] pyridoxal_phosphate at position 6
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 109 sequences 

CNSB_PENEN  (A0A0A2IDH4), CSAD_MOUSE  (Q9DBE0), CSAD_RAT(Q64611), 

DCE1_BOVIN  (Q0VCA1), DCE1_CANLF  (A0PA85), DCE1_FELCA  (P14748), 
DCE1_HUMAN  (Q99259), DCE1_MOUSE  (P48318), DCE1_PANTR  (Q5IS68), 
DCE1_PIG(P48319), DCE1_PONAB  (Q5R7S7), DCE1_RAT(P18088), 
DCE2_CANLF  (Q4PRC2), DCE2_HUMAN  (Q05329), DCE2_MOUSE  (P48320), 
DCE2_PIG(P48321), DCE2_RAT(Q05683), DCEA_ECO57  (P58228), 
DCEA_ECOL6  (P69909), DCEA_ECOLI  (P69908), DCEA_SHIFL  (Q83PR1), 
DCEB_ECO57  (P69911), DCEB_ECOL6  (Q8FHG5), DCEB_ECOLI  (P69910), 
DCEB_SHIFL  (P69912), DCE_DROME   (P20228), DCHS_ACIB3  (B7GZJ8), 
DCHS_ACIB5  (B7I459), DCHS_ACIBC  (B2HVG6), DCHS_ACIBT  (A3M7A4), 
DCHS_ACIBY  (B0VBU8), DCHS_BOVIN  (Q5EA83), DCHS_DROME  (Q05733), 
DCHS_HUMAN  (P19113), DCHS_KLEAE  (P28577), DCHS_MORMO  (P05034), 
DCHS_MOUSE  (P23738), DCHS_PSEE4  (Q1IAK7), DCHS_PSEFL  (P95477), 
DCHS_RAOOR  (Q8L0Z4), DCHS_RAOPL  (P28578), DCHS_RAT(P16453), 
DCHS_SOLLC  (P54772), DCHS_VIBA7  (Q56581), DCHS_VIBC1  (A7MVI6), 
DDC_ACIBA   (Q43908), DDC_BOVIN   (P27718), DDC_CAVPO   (P22781), 
DDC_DROLE   (O96571), DDC_DROME   (P05031), DDC_DROSI   (O96567), 
DDC_HAEIN   (P71362), DDC_HUMAN   (P20711), DDC_MANSE   (P48861), 
DDC_MOUSE   (O88533), DDC_PIG (P80041), DDC_RAT (P14173), 
DHAPP_DROLE (O96569), DHAPP_DROME (P18486), DHAPP_DROSI (P81893), 
DHPAA_AEDAE (Q16S21), GADL1_BOVIN (A6QM00), GADL1_HUMAN (Q6ZQY3), 
GADL1_MOUSE (Q80WP8), GADL1_XENTR (Q28D99), HPAAS_PETCR (Q06086), 
MFNA_ARCFU  (O28275), MFNA_META3  (A6UVR4), MFNA_METLZ  (A2STQ3), 
MFNA_METM5  (A4G060), MFNA_METM7  (A6VIC0), MFNA_METMJ  (A3CWM4), 
MFNA_METMP  (Q6M0Y7), MFNA_METPE  (B8GDM7), MFNA_METS3  (A5ULW4), 
MFNA_METTP  (A0B9M9), MFNA_METVS  (A6URB4), MFNA_PYRAB  (Q9UZD5), 
MFNA_PYRFU  (Q8U1P6), MFNA_PYRHO  (O58679), MFNA_THEGJ  (C5A2X8), 
MFNA_THEKO  (Q5JJ82), PAAS_ARATH  (Q8RY79), PAAS_PETHY  (Q0ZQX0), 
PAAS_ROSHC  (Q0ZS27), RHBB_RHIME  (Q9Z3R1), SDC1_ARATH  (Q9MA74), 
SDC1_ORYSJ  (Q6ESZ9), SDC2_ORYSJ  (Q8RV06), SDC3_ORYSJ  (Q7X8D4), 
TDC1_CAEEL  (Q95ZS2), TDC1_CAMAC  (P93082), TDC1_ORYSJ  (Q6ZJK7), 
TDC2_CAMAC  (P93083), TDC2_ORYSJ  (Q7XHL3), TDC_CATRO   (P17770), 
TRPDC_MEDG7 (A7B1V0), TYDC1_NARPS (A0A2H5AIY0), TYDC1_PAPSO (P54768), 
TYDC1_PETCR (Q06085), TYDC2_LOPWI (A0AA51Z3J4), TYDC2_NARPS (A0A2H5AIY2), 
TYDC2_PAPSO (P54769), TYDC3_PAPSO (P54770), TYDC3_PETCR (Q06087), 
TYDC4_PETCR (Q06088), TYDC5_PAPSO (P54771), TYDC_PAPSO  (O82415), 
TYRDC_ENTFC (A0A481NV25)
» more

UniProtKB/Swiss-Prot
False negative sequences		 47 sequences 

AADC_BACAT  (I0DFJ0), CSAD_HUMAN  (Q9Y600), DCE1_ARATH  (Q42521), 

DCE2_ARATH  (Q42472), DCEA_LISMO  (Q9F5P3), DCEB_LISIN  (Q928R9), 
DCEB_LISMO  (Q9EYW9), DCEC_LISIN  (Q928K4), DCEC_LISMO  (Q8Y4K4), 
DCE_LACLA   (Q9CG20), DCE_LACLM   (O30418), DCE_PETHY   (Q07346), 
DCE_SOLLC   (P54767), DCE_YEAST   (Q04792), DCHS_RHILO  (Q98A07), 
DDC_CAEEL   (P34751), GADA_DICDI  (Q54VQ5), GADB_DICDI  (Q54IJ3), 
MFNA_HALMA  (Q5V1B4), MFNA_HALS3  (B0R349), MFNA_HALSA  (Q9HSA3), 
MFNA_METAC  (Q8TUQ9), MFNA_METAR  (Q0W498), MFNA_METB6  (A7IAB9), 
MFNA_METBF  (Q46DU3), MFNA_METBU  (Q12VA2), MFNA_METHJ  (Q2FSD2), 
MFNA_METJA  (Q60358), MFNA_METKA  (Q8TV92), MFNA_METMA  (Q8PXA5), 
MFNA_METST  (Q2NHY7), MFNA_METTH  (O27188), MFNA_NATPD  (Q3IT46), 
PDXD1_HUMAN (Q6P996), PDXD1_MOUSE (Q99K01), PDXD1_XENLA (Q6DF78), 
PDXD2_HUMAN (Q6P474), SGPL1_HUMAN (O95470), SGPL1_MOUSE (Q8R0X7), 
SGPL1_PONAB (Q5R4G0), SGPL1_RAT   (Q8CHN6), SGPL_ARATH  (Q9C509), 
SGPL_CAEEL  (Q9Y194), SGPL_DROME  (Q9V7Y2), SGPL_YEAST  (Q05567), 
TRPDC_CLOS1 (J7SZ64), TYDC2_ARATH (Q9M0G4)
» more

UniProtKB/Swiss-Prot
False positive sequences		 10 sequences 

ATG1B_ARATH (F4JBP3), CCME_EHRCJ  (Q3YSH2), CCME_EHRCR  (Q2GG46), 

CCME_EHRRG  (Q5FHG0), CCME_EHRRW  (Q5HBM4), CH101_VIBCH (Q9KNR6), 
HS7C4_DICDI (Q54BD8), MMS1_YEAST  (Q06211), NUOD_SPHAL  (Q1GTK0), 
RMT2_YARLI  (Q6CBX2)
» more

PDB
[Detailed view]		 42 PDB

pdb_00001js3; pdb_00001js6; pdb_00001pmm; pdb_00001pmo; pdb_00001xey; pdb_00002dgk; pdb_00002dgl; pdb_00002dgm; pdb_00002okj; pdb_00002okk; pdb_00003fz6; pdb_00003fz7; pdb_00003fz8; pdb_00003k40; pdb_00003rbf; pdb_00003rbl; pdb_00003rch; pdb_00003vp6; pdb_00004e1o; pdb_00004obu; pdb_00004obv; pdb_00006eei; pdb_00006eem; pdb_00006eew; pdb_00006enz; pdb_00006jrl; pdb_00006khn; pdb_00006kho; pdb_00006khp; pdb_00006liu; pdb_00006liv; pdb_00006zek; pdb_00007a0a; pdb_00007eiw; pdb_00007eix; pdb_00007eiy; pdb_00007lz6; pdb_00008jg7; pdb_00008or9; pdb_00008ora; pdb_00008x0o; pdb_00008x0p
» more