We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS00393

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PURL: https://purl.expasy.org/prosite/signature/PS00393

Direct ScanProsite submission

General information about the entry

Entry name [info]	PEPCASE_2
Accession [info]	PS00393
Entry type [info]	PATTERN
Date [info]	01-NOV-1990 CREATED; 01-DEC-2004 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00330
Associated ProRule [info]	PRU10112

Name and characterization of the entry

Description [info]	Phosphoenolpyruvate carboxylase active site 2.
Pattern [info]	[IVLC]-M-[LIVM]-G-Y-S-D-S-x-K-[DF]-[STAG]-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	228 in 228 different sequences
Number of true positive hits	228 in 228 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	2
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	99.13 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Site [info]	active_site at position 10
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

228 sequences

CAPP1_ARATH (Q9MAH0), CAPP1_CHLRE (P81831), CAPP1_FLAPR (Q01647),

CAPP1_MAIZE (P04711), CAPP1_MESCR (P10490), CAPP1_SACHY (P29193), 
CAPP1_SORBI (P29195), CAPP1_SOYBN (Q02909), CAPP2_ARATH (Q5GM68), 
CAPP2_CHLRE (Q6R2V6), CAPP2_MAIZE (P51059), CAPP2_MESCR (P16097), 
CAPP2_SORBI (P29194), CAPP2_SOYBN (P51061), CAPP3_ARATH (Q84VW9), 
CAPP3_SORBI (P15804), CAPP4_ARATH (Q8GVE8), CAPPA_FLATR (P30694), 
CAPPB_FLATR (Q9FV66), CAPPC_FLATR (Q9FV65), CAPP_ACIAD  (Q6F6Q6), 
CAPP_ACIBT  (A3MA94), CAPP_ACTP2  (A3MZ57), CAPP_AERHH  (A0KFU8), 
CAPP_AERS4  (A4SIM0), CAPP_ALCBS  (Q0VRS0), CAPP_ALIF1  (Q5E2E3), 
CAPP_ALIFM  (B5FBP8), CAPP_ALISL  (B6EMN4), CAPP_AMAHP  (Q43299), 
CAPP_AROAE  (Q5P7H5), CAPP_AZOC5  (A8I060), CAPP_AZOSB  (A1K454), 
CAPP_BORBR  (Q7WQB3), CAPP_BORPA  (Q7WCA9), CAPP_BORPE  (Q7W0D0), 
CAPP_BRADU  (Q89R17), CAPP_BURM7  (A3MLK7), CAPP_BURM9  (A2SAH4), 
CAPP_BURMA  (Q62LC1), CAPP_BURMS  (A1V5U2), CAPP_BURP6  (A3N6Z8), 
CAPP_BURPS  (Q63W75), CAPP_BURVG  (A4JGV5), CAPP_CAUVC  (Q9A871), 
CAPP_CHRSD  (Q1QX15), CAPP_CHRVO  (Q7P206), CAPP_CITK8  (A8AKW6), 
CAPP_CORDI  (P61448), CAPP_COREF  (Q8RQL3), CAPP_CORGL  (P12880), 
CAPP_CORGT  (Q93MH3), CAPP_ECO24  (A7ZUH4), CAPP_ECO27  (B7UNT2), 
CAPP_ECO45  (B7MI92), CAPP_ECO55  (B7LA56), CAPP_ECO57  (Q8X743), 
CAPP_ECO5E  (B5Z058), CAPP_ECO7I  (B7NU44), CAPP_ECO81  (B7MR83), 
CAPP_ECO8A  (B7M710), CAPP_ECOBW  (C5A0C2), CAPP_ECODH  (B1XBC1), 
CAPP_ECOHS  (A8A764), CAPP_ECOK1  (A1AID4), CAPP_ECOL5  (Q0TAA4), 
CAPP_ECOL6  (Q8FB98), CAPP_ECOLC  (B1IVC2), CAPP_ECOLI  (P00864), 
CAPP_ECOLU  (B7NFQ6), CAPP_ECOSE  (B6I5H2), CAPP_ECOSM  (B1LNR6), 
CAPP_ECOUT  (Q1R3V5), CAPP_ECTM1  (A4XXP6), CAPP_EDWI9  (C5BC63), 
CAPP_ENT38  (A4WG55), CAPP_ERWT9  (B2VGA2), CAPP_ESCF3  (B7LUN9), 
CAPP_GLOVI  (Q7NNJ7), CAPP_HAEI8  (Q4QL71), CAPP_HAEIE  (A5UCN0), 
CAPP_HAEIG  (A5UIY9), CAPP_HAEIN  (P43920), CAPP_HAHCH  (Q2SL23), 
CAPP_HISS1  (Q0I371), CAPP_HISS2  (B0UUJ3), CAPP_KLEP3  (B5XZ20), 
CAPP_LACAC  (Q5FK38), CAPP_LACDA  (Q1GBD4), CAPP_LACH4  (A8YVD9), 
CAPP_MARMS  (A6VUQ5), CAPP_MARN8  (A1U2U4), CAPP_MEDSA  (Q02735), 
CAPP_METEA  (Q49136), CAPP_MYCA1  (A0QHY0), CAPP_MYCLE  (P46710), 
CAPP_MYCPA  (P61449), CAPP_MYCS2  (A0QWX4), CAPP_MYCUA  (A0PPN8), 
CAPP_NEIG1  (Q5F5A9), CAPP_NEIMA  (Q9JWH1), CAPP_NEIMB  (Q9JXG5), 
CAPP_NEIMF  (A1KWE0), CAPP_NITEC  (Q0AH90), CAPP_NITEU  (Q82WS3), 
CAPP_NOCFA  (Q5YYG7), CAPP_NOSS1  (P28594), CAPP_PARMW  (Q7U4M0), 
CAPP_PARXL  (Q143B6), CAPP_PASMU  (Q9CN89), CAPP_PEA(P51062), 
CAPP_PECAS  (Q6DAR6), CAPP_PECCP  (C6DI86), CAPP_PHAVU  (Q9AU12), 
CAPP_PHOLL  (Q7MAX5), CAPP_PHOPR  (Q6LVH1), CAPP_PICAB  (P51063), 
CAPP_PROM0  (A3PF64), CAPP_PROM2  (A8G779), CAPP_PROM5  (A2BYV8), 
CAPP_PROM9  (Q318G7), CAPP_PROMA  (Q7V9U4), CAPP_PROMH  (B4F183), 
CAPP_PROMM  (Q7V561), CAPP_PROMP  (Q7UZT0), CAPP_PROMS  (A2BTF4), 
CAPP_PSE14  (Q48F34), CAPP_PSEAE  (Q9HXV3), CAPP_PSEE4  (Q1IDV2), 
CAPP_PSEF5  (Q4KHK5), CAPP_PSEP1  (A5W881), CAPP_PSEP7  (A6V1A0), 
CAPP_PSEPF  (Q3KHE4), CAPP_PSEPG  (B0KS63), CAPP_PSEPK  (Q88MR4), 
CAPP_PSESM  (Q886R9), CAPP_PSET1  (Q3IBX6), CAPP_PSEU2  (Q4ZWV3), 
CAPP_PSYIN  (A1SRH8), CAPP_RALN1  (Q8XWW2), CAPP_RHOMR  (Q59757), 
CAPP_RHOP2  (Q2IU23), CAPP_RHOP5  (Q07QP5), CAPP_RHOPA  (O32483), 
CAPP_RHOPB  (Q218E3), CAPP_RHOPS  (Q139X8), CAPP_SALAR  (A9MI14), 
CAPP_SALCH  (Q57H97), CAPP_SALDC  (B5FPX1), CAPP_SALEP  (B5QXQ1), 
CAPP_SALG2  (B5RF49), CAPP_SALHS  (B4TCQ2), CAPP_SALNS  (B4T0W7), 
CAPP_SALPA  (Q5PK55), CAPP_SALPB  (A9N0G6), CAPP_SALPC  (C0Q472), 
CAPP_SALPK  (B5BJN0), CAPP_SALSV  (B4TQH2), CAPP_SALTI  (Q8Z307), 
CAPP_SALTY  (Q8ZKM0), CAPP_SERP5  (A8GL86), CAPP_SHEHH  (B0TL90), 
CAPP_SHELP  (A3Q9C4), CAPP_SHEON  (Q8EK30), CAPP_SHEPA  (A8GZ16), 
CAPP_SHESH  (A8G1A9), CAPP_SHIB3  (B2TWF1), CAPP_SHIBS  (Q31U32), 
CAPP_SHIDS  (Q32AB9), CAPP_SHIF8  (Q0SY38), CAPP_SHIFL  (Q83IS7), 
CAPP_SHISS  (Q3YV20), CAPP_SOLTU  (P29196), CAPP_STRA1  (Q3K1U6), 
CAPP_STRA3  (Q8E647), CAPP_STRA5  (Q8E0H2), CAPP_STRAW  (Q82HE3), 
CAPP_STRCO  (Q9RNU9), CAPP_STRGC  (A8AW99), CAPP_STRMU  (Q8DV10), 
CAPP_STRP1  (Q9A0U7), CAPP_STRP2  (Q04KL8), CAPP_STRP3  (P0DC98), 
CAPP_STRP6  (Q5XD52), CAPP_STRP8  (Q8P1W7), CAPP_STRPG  (A2RFQ7), 
CAPP_STRPN  (Q97QX6), CAPP_STRPQ  (P0DC99), CAPP_STRR6  (Q8DPW5), 
CAPP_STRS2  (A4VZZ0), CAPP_STRSV  (A3CP10), CAPP_STRSY  (A4VTQ4), 
CAPP_STRT1  (Q5M0E6), CAPP_STRT2  (Q5M4Z3), CAPP_STRTD  (Q03LA9), 
CAPP_STUS1  (A4VN44), CAPP_SYNP6  (P06516), CAPP_SYNPW  (A5GIW5), 
CAPP_SYNY3  (P74299), CAPP_THES7  (P51060), CAPP_THET2  (Q72L05), 
CAPP_THET8  (Q5SKL7), CAPP_THEVB  (P0A3X5), CAPP_THEVL  (P0A3X6), 
CAPP_TOBAC  (P27154), CAPP_TOLAT  (C4L7S3), CAPP_TRIV2  (Q3MB82), 
CAPP_VEREI  (A1WGR0), CAPP_VIBA3  (B7VLL5), CAPP_VIBCH  (Q9KNT4), 
CAPP_VIBPA  (Q87L54), CAPP_VIBVU  (Q8DCN2), CAPP_VIBVY  (Q7MH68), 
CAPP_XANAC  (Q8PP82), CAPP_XANC8  (Q4UR00), CAPP_XANCP  (Q8P336), 
CAPP_XANE5  (Q3BXC4), CAPP_XANOM  (Q2NZE4), CAPP_XANOR  (Q5GW71), 
CAPP_YERE8  (A1JI20), CAPP_YERP3  (A7FCZ7), CAPP_YERPA  (Q1CBV8), 
CAPP_YERPB  (B2JZD9), CAPP_YERPE  (Q8ZA84), CAPP_YERPN  (Q1CNQ7), 
CAPP_YERPP  (A4TRH7), CAPP_YERPS  (Q66G74), CAPP_YERPY  (B1JQ63)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

2 sequences

CAPP_PAEAT  (A1R2V3), CAPP_ROSCS  (A7NLR3)

PDB
[Detailed view]

24 PDB

pdb_00001fiy; pdb_00001jqn; pdb_00001jqo; pdb_00001qb4; pdb_00003zgb; pdb_00003zge; pdb_00004bxc; pdb_00004bxh; pdb_00005fdn; pdb_00005vyj; pdb_00006mgi; pdb_00006u2t; pdb_00006v3o; pdb_00008cj5; pdb_00008cj8; pdb_00008oj9; pdb_00008oje; pdb_00008ojf; pdb_00008ojq; pdb_00008ojy; pdb_00008ojz; pdb_00008qtm; pdb_00008qx1; pdb_00008qx3
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