|PROSITE documentation PDOC00332 [for PROSITE entry PS00395]|
Alanine racemase (EC 22.214.171.124)  catalyzes the pyridoxal-dependent conversion of L-alanine into D-alanine, a key building block of bacterial peptidoglycan. In bacteria such as Escherichia coli or Salmonella typhimurium, there are two forms of alanine racemase: a biosynthetic form (alr) required for cell wall formation and a form (dadB) that functions in L-alanine catabolism. In contrast to dadB and alr which are monomeric enzymes, the alanine racemase of Bacillaceae are homodimers.
The pyridoxal-phosphate group of alanine racemase is attached to a lysine residue. The sequence around this residue is highly conserved in all forms of the enzyme.Last update:
February 2002 / Pattern revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Hayashi H., Wada H., Yoshimura T., Esaki N., Soda K.|
|Title||Recent topics in pyridoxal 5'-phosphate enzyme studies.|
|Source||Annu. Rev. Biochem. 59:87-110(1990).|