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PROSITE documentation PDOC00335 [for PROSITE entry PS00399] |
Four different enzymes share a similar catalytic mechanism which involves the phosphorylation by ATP (or GTP) of a specific histidine residue in the active site. These enzymes are:
We developed three signature patterns for these enzymes, the first corresponds to a glycine-rich conserved region, located in the second half of ATP citrate lyase and in the α subunits of succinyl-CoA ligases and malate-CoA ligase. The second pattern, which is located some 50 residues to the C-terminal of the first one, includes the active site phosphorylated histidine residue. The last pattern corresponds to a conserved region located in the first half of ATP citrate lyase and in the β subunits of succinyl-CoA ligases and malate-CoA ligase.
Last update:April 2006 / Pattern revised.
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PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Elshourbagy N.A. Near J.C. Kmetz P.J. Wells T.N. Groot P.H. Saxty B.A. Hughes S.A. Franklin M. Gloger I.S. |
Title | Cloning and expression of a human ATP-citrate lyase cDNA. | |
Source | Eur. J. Biochem. 204:491-499(1992). | |
PubMed ID | 1371749 |
2 | Authors | Bailey D.L. Wolodko W.T. Bridger W.A. |
Title | Cloning, characterization, and expression of the beta subunit of pig heart succinyl-CoA synthetase. | |
Source | Protein Sci. 2:1255-1262(1993). | |
PubMed ID | 8401211 |
3 | Authors | Buck D. Spencer M.E. Guest J.R. |
Title | Primary structure of the succinyl-CoA synthetase of Escherichia coli. | |
Source | Biochemistry 24:6245-6252(1985). | |
PubMed ID | 3002435 |
4 | Authors | Chistoserdova L.V. Lidstrom M.E. |
Title | Genetics of the serine cycle in Methylobacterium extorquens AM1: identification, sequence, and mutation of three new genes involved in C1 assimilation, orf4, mtkA, and mtkB. | |
Source | J. Bacteriol. 176:7398-7404(1994). | |
PubMed ID | 7961516 |