Peroxisomal carnitine octanoyltransferase (EC 2.3.1.-) (COT), a fatty acid
β-oxidation pathway enzyme which is involved in the transport of medium-
chain acyl-coenzyme A's from peroxisome to mitochondria .
Mitochondrial carnitine O-palmitoyltransferases I and II (EC 188.8.131.52)
(CPT), enzymes involved in fatty acid metabolism and transport .
These enzymes share many regions of sequence similarities. As signature
patterns we selected two of these regions. The first one, located in the
N-terminal section of these enzymes is characterized by the presence of three
[LIVM]-P dipeptides. The second region, located in the central part of these
enzymes is characterized by the conservation of a number of charged residues
including an histidine which probably plays a crucial role in the catalytic
Esser V. Britton C.H. Weis B.C. Foster D.W. McGarry J.D.
Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function.
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