![]() |
|
PROSITE documentation PDOC00428 [for PROSITE entry PS00468] |
In eukaryotes, a number of proteins are involved in the binding and transport of cobalamin (vitamin B12) [1]. Some of them have been sequenced and have been shown [2,3] to be evolutionary related and are listed below:
These glycoproteins are polypeptides of about 400 amino acids that share many regions of similarity. As a signature pattern, we selected a highly conserved region in their central part.
Last update:April 2006 / Pattern revised.
-------------------------------------------------------------------------------
PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Seetharam B. Alpers D.H. |
Title | Absorption and transport of cobalamin (vitamin B12). | |
Source | Annu. Rev. Nutr. 2:343-369(1982). | |
PubMed ID | 6313022 | |
DOI | 10.1146/annurev.nu.02.070182.002015 |
2 | Authors | Platica O. Janeczko R. Quadros E.V. Regec A. Romain R. Rothenberg S.P. |
Title | The cDNA sequence and the deduced amino acid sequence of human transcobalamin II show homology with rat intrinsic factor and human transcobalamin I. | |
Source | J. Biol. Chem. 266:7860-7863(1991). | |
PubMed ID | 1708393 |
3 | Authors | Li N. Seetharam S. Lindemans J. Alpers D.H. Arwert F. Seetharam B. |
Title | Isolation and sequence analysis of variant forms of human transcobalamin II. | |
Source | Biochim. Biophys. Acta 1172:21-30(1993). | |
PubMed ID | 8439564 |