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PROSITE entry PS00471


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PURL: https://purl.expasy.org/prosite/signature/PS00471

Direct ScanProsite submission
General information about the entry

Entry name [info] SMALL_CYTOKINES_CXC
Accession [info] PS00471
Entry type [info] PATTERN
Date [info] 01-MAY-1991 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00434

Name and characterization of the entry

Description [info] Small cytokines (intercrine/chemokine) C-x-C subfamily signature.
Pattern [info] 
C-x-C-[LIVMS]-x(4,6)-[LIVMFY]-x(2)-[RKSEQNA]-x-[LIVM]-x(2)-[LIVMA]-x(5)-
[STAG]-x(2)-C-x(3)-[EQ]-[LIVM](2)-x(9,10)-C-[LV]-[DN].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 65 in 65 different sequences
Number of true positive hits 65 in 65 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 16
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 80.25 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 3
Site [info] disulfide at position 16
Site [info] disulfide at position 21
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 65 sequences 

AMC2_PIG(P22952), AMC_RABIT   (P82535), CX116_DANRE (B0R191), 

CXCL2_HUMAN (P19875), CXCL2_MOUSE (P10889), CXCL2_RAT   (P30348), 
CXCL3_HUMAN (P19876), CXCL3_MOUSE (Q6W5C0), CXCL3_RAT   (Q10746), 
CXCL5_HUMAN (P42830), CXCL5_MOUSE (P50228), CXCL5_RAT   (P97885), 
CXCL6_BOVIN (P80221), CXCL6_HORSE (Q8MIN2), CXCL6_HUMAN (P80162), 
CXCL7_HUMAN (P02775), CXCL7_PIG   (P43030), CXCL9_BOVIN (A9QWP9), 
CXCL9_HUMAN (Q07325), CXCL9_MOUSE (P18340), CXL10_BOVIN (Q2KIQ8), 
CXL10_CANLF (Q5KSV9), CXL10_HUMAN (P02778), CXL10_MACMU (Q8MIZ1), 
CXL10_MACNE (Q865F5), CXL10_MOUSE (P17515), CXL10_RAT   (P48973), 
CXL11_BOVIN (A9QWQ1), CXL11_HUMAN (O14625), CXL11_MOUSE (Q9JHH5), 
CXL13_HUMAN (O43927), CXL13_MOUSE (O55038), CXL15_MOUSE (Q9WVL7), 
GRO2_RABIT  (P47854), GROA_BOVIN  (O46676), GROA_CAVPO  (O55235), 
GROA_CRIGR  (P09340), GROA_HUMAN  (P09341), GROA_MOUSE  (P12850), 
GROA_RAT(P14095), GROA_SHEEP  (O46678), GROB_BOVIN  (O46677), 
GROG_BOVIN  (O46675), IL8_BOVIN   (P79255), IL8_CANLF   (P41324), 
IL8_CAVPO   (P49113), IL8_CERAT   (P46653), IL8_CHICK   (P08317), 
IL8_DASNO   (Q102R3), IL8_FELCA   (Q9XSX5), IL8_HORSE   (O62812), 
IL8_HUMAN   (P10145), IL8_MACMU   (P67813), IL8_MACNE   (P67814), 
IL8_PIG (P26894), IL8_RABIT   (P19874), IL8_SHEEP   (P36925), 
IL8_TURTR   (Q7YRB5), PF4V_HUMAN  (P10720), PLF4_BOVIN  (P02777), 
PLF4_HUMAN  (P02776), PLF4_MOUSE  (Q9Z126), PLF4_PIG(P30034), 
PLF4_RAT(P06765), PLF4_SHEEP  (P30035)
» more

UniProtKB/Swiss-Prot
False negative sequences		 16 sequences 

CX111_DANRE (A0A0R4INB9), CXL14_HUMAN (O95715), CXL14_MOUSE (Q9WUQ5), 

CXL16_BOVIN (Q29RT9), CXL16_HUMAN (Q9H2A7), CXL16_MOUSE (Q8BSU2), 
CXL16_PIG   (Q9GKE2), CXL16_RAT   (Q6AXU5), CXL17_BOVIN (A4IFR0), 
CXL17_HUMAN (Q6UXB2), CXL17_MOUSE (Q5UW37), SDF1_FELCA  (O62657), 
SDF1_HUMAN  (P48061), SDF1_MOUSE  (P40224), SDF1_XENLA  (Q8UUJ9), 
SDF1_XENTR  (Q5EBF6)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

GRO1_RABIT  (P30782), PLF4_RABIT  (P83470)


				
	

	

		PDB
[Detailed view]		
		
			67 PDB
			


			pdb_00001f9p; pdb_00001f9q; pdb_00001f9r; pdb_00001f9s; pdb_00001ikl; pdb_00001ikm; pdb_00001il8; pdb_00001ilp; pdb_00001ilq; pdb_00001lv9; pdb_00001mgs; pdb_00001mi2; 
			
				pdb_00001msg; pdb_00001msh; pdb_00001nap; pdb_00001o7y; pdb_00001o7z; pdb_00001o80; pdb_00001pfm; pdb_00001pfn; pdb_00001plf; pdb_00001qe6; pdb_00001qnk; pdb_00001rhp; 
				pdb_00001rjt; pdb_00001rod; pdb_00001tvx; pdb_00002il8; pdb_00002mgs; pdb_00002r3z; pdb_00003il8; pdb_00003n52; pdb_00004hsv; pdb_00004r9w; pdb_00004r9y; pdb_00004rau; 
				pdb_00004xdx; pdb_00005cba; pdb_00005cbe; pdb_00005d14; pdb_00005izb; pdb_00005l7m; pdb_00005ob5; pdb_00005wdz; pdb_00006lfm; pdb_00006lfo; pdb_00006n2u; pdb_00006vgj; 
				pdb_00006wzm; pdb_00006xmn; pdb_00007jny; pdb_00008hnk; pdb_00008ic0; pdb_00008k2x; pdb_00008k4o; pdb_00008xvu; pdb_00008xwa; pdb_00008xwf; pdb_00008xwm; pdb_00008xwn; 
				pdb_00008xws; pdb_00008xwv; pdb_00008xx3; pdb_00008xx6; pdb_00008xx7; pdb_00008xxh; pdb_00008xxx
			
			

			» more