PROSITE entry PS00471
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General information about the entry
| PURL [info] | https://purl.expasy.org/prosite/signature/PS00471 |
| Entry name [info] | SMALL_CYTOKINES_CXC |
| Accession [info] | PS00471 |
| Entry type [info] | PATTERN |
| Date [info] |
01-MAY-1991 CREATED;
01-APR-2006 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00434 |
Name and characterization of the entry
| Description [info] | Small cytokines (intercrine/chemokine) C-x-C subfamily signature. |
| Pattern [info] |
C-x-C-[LIVMS]-x(4,6)-[LIVMFY]-x(2)-[RKSEQNA]-x-[LIVM]-x(2)-[LIVMA]-x(5)- [STAG]-x(2)-C-x(3)-[EQ]-[LIVM](2)-x(9,10)-C-[LV]-[DN]. |
Numerical results [info]
| Total number of hits | 65 in 65 different sequences |
| Number of true positive hits | 65 in 65 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 16 |
| Number of 'partial' sequences | 2 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 80.25 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Site [info] | disulfide at position 1 |
| Site [info] | disulfide at position 3 |
| Site [info] | disulfide at position 16 |
| Site [info] | disulfide at position 21 |
| Version [info] | 2 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
65 sequences
AMC2_PIG(P22952), AMC_RABIT (P82535), CX116_DANRE (B0R191), CXCL2_HUMAN (P19875), CXCL2_MOUSE (P10889), CXCL2_RAT (P30348), CXCL3_HUMAN (P19876), CXCL3_MOUSE (Q6W5C0), CXCL3_RAT (Q10746), CXCL5_HUMAN (P42830), CXCL5_MOUSE (P50228), CXCL5_RAT (P97885), CXCL6_BOVIN (P80221), CXCL6_HORSE (Q8MIN2), CXCL6_HUMAN (P80162), CXCL7_HUMAN (P02775), CXCL7_PIG (P43030), CXCL9_BOVIN (A9QWP9), CXCL9_HUMAN (Q07325), CXCL9_MOUSE (P18340), CXL10_BOVIN (Q2KIQ8), CXL10_CANLF (Q5KSV9), CXL10_HUMAN (P02778), CXL10_MACMU (Q8MIZ1), CXL10_MACNE (Q865F5), CXL10_MOUSE (P17515), CXL10_RAT (P48973), CXL11_BOVIN (A9QWQ1), CXL11_HUMAN (O14625), CXL11_MOUSE (Q9JHH5), CXL13_HUMAN (O43927), CXL13_MOUSE (O55038), CXL15_MOUSE (Q9WVL7), GRO2_RABIT (P47854), GROA_BOVIN (O46676), GROA_CAVPO (O55235), GROA_CRIGR (P09340), GROA_HUMAN (P09341), GROA_MOUSE (P12850), GROA_RAT(P14095), GROA_SHEEP (O46678), GROB_BOVIN (O46677), GROG_BOVIN (O46675), IL8_BOVIN (P79255), IL8_CANLF (P41324), IL8_CAVPO (P49113), IL8_CERAT (P46653), IL8_CHICK (P08317), IL8_DASNO (Q102R3), IL8_FELCA (Q9XSX5), IL8_HORSE (O62812), IL8_HUMAN (P10145), IL8_MACMU (P67813), IL8_MACNE (P67814), IL8_PIG (P26894), IL8_RABIT (P19874), IL8_SHEEP (P36925), IL8_TURTR (Q7YRB5), PF4V_HUMAN (P10720), PLF4_BOVIN (P02777), PLF4_HUMAN (P02776), PLF4_MOUSE (Q9Z126), PLF4_PIG(P30034), PLF4_RAT(P06765), PLF4_SHEEP (P30035)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
16 sequences
CX111_DANRE (A0A0R4INB9), CXL14_HUMAN (O95715), CXL14_MOUSE (Q9WUQ5), CXL16_BOVIN (Q29RT9), CXL16_HUMAN (Q9H2A7), CXL16_MOUSE (Q8BSU2), CXL16_PIG (Q9GKE2), CXL16_RAT (Q6AXU5), CXL17_BOVIN (A4IFR0), CXL17_HUMAN (Q6UXB2), CXL17_MOUSE (Q5UW37), SDF1_FELCA (O62657), SDF1_HUMAN (P48061), SDF1_MOUSE (P40224), SDF1_XENLA (Q8UUJ9), SDF1_XENTR (Q5EBF6)» more |
| UniProtKB/Swiss-Prot 'Partial' sequences |
2 sequences
GRO1_RABIT (P30782), PLF4_RABIT (P83470) |
| PDB [Detailed view] |
67 PDB
1F9P; 1F9Q; 1F9R; 1F9S; 1IKL; 1IKM; 1IL8; 1ILP; 1ILQ; 1LV9; 1MGS; 1MI2; 1MSG; 1MSH; 1NAP; 1O7Y; 1O7Z; 1O80; 1PFM; 1PFN; 1PLF; 1QE6; 1QNK; 1RHP; 1RJT; 1ROD; 1TVX; 2IL8; 2MGS; 2R3Z; 3IL8; 3N52; 4HSV; 4R9W; 4R9Y; 4RAU; 4XDX; 5CBA; 5CBE; 5D14; 5IZB; 5L7M; 5OB5; 5WDZ; 6LFM; 6LFO; 6N2U; 6VGJ; 6WZM; 6XMN; 7JNY; 8HNK; 8IC0; 8K2X; 8K4O; 8XVU; 8XWA; 8XWF; 8XWM; 8XWN; 8XWS; 8XWV; 8XX3; 8XX6; 8XX7; 8XXH; 8XXX » more |