Home  |  Contact
PROSITE documentation PDOC00419 [for PROSITE entry PS00485]

Adenosine and AMP deaminase signature





Description

Adenosine deaminase (EC 3.5.4.4) catalyzes the hydrolytic deamination of adenosine into inosine. AMP deaminase (EC 3.5.4.6) catalyzes the hydrolytic deamination of AMP into IMP. It has been shown [1] that these two types of enzymes share three regions of sequence similarities; these regions are centered on residues which are proposed to play an important role in the catalytic mechanism of these two enzymes. We have selected one of these regions, it contains two conserved aspartic acid residues that are potential active site residues.

Last update:

May 2004 / Text revised.

-------------------------------------------------------------------------------

Technical section

PROSITE method (with tools and information) covered by this documentation:

A_DEAMINASE, PS00485; Adenosine and AMP deaminase signature  (PATTERN)


Reference

1AuthorsChang Z.Y. Nygaard P. Chinault A.C. Kellems R.E.
TitleDeduced amino acid sequence of Escherichia coli adenosine deaminase reveals evolutionarily conserved amino acid residues: implications for catalytic function.
SourceBiochemistry 30:2273-2280(1991).
PubMed ID1998686



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

Miscellaneous

View entry in original PROSITE document format
View entry in raw text format (no links)