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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00485


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PURL: https://purl.expasy.org/prosite/signature/PS00485

Direct ScanProsite submission
General information about the entry

Entry name [info] A_DEAMINASE
Accession [info] PS00485
Entry type [info] PATTERN
Date [info] 01-MAY-1991 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00419
Associated ProRule [info] PRU10104

Name and characterization of the entry

Description [info] Adenosine and AMP deaminase signature.
Pattern [info] 
[SA]-[LIVM]-[NGS]-[STA]-D-D-P.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 110 in 110 different sequences
Number of true positive hits 89 in 89 different sequences
Number of 'unknown' hits 0
Number of false positive hits 21 in 21 different sequences
Number of false negative sequences 97
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 80.91 %
Recall (true positives / (true positives + false negatives)) 47.85 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site(?) at position 5
Site [info] active_site(?) at position 6
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 89 sequences 

ADA_BOVIN   (P56658), ADA_CHICK   (Q5ZKP6), ADA_DANRE   (Q6DG22), 

ADA_HUMAN   (P00813), ADA_MOUSE   (P03958), ADA_PLABA   (A0A509ALD0), 
ADA_PLACD   (K6UCV4), ADA_PLAF7   (Q8IJA9), ADA_PLAGA   (A0A0K1SC59), 
ADA_PLAKN   (A0A1Y3DYH2), ADA_PLAVS   (A5KE01), ADA_RAT (Q920P6), 
ADA_XENLA   (Q6GP70), ADA_XENTR   (Q63ZU0), ADDL_STRCO  (Q9L0L6), 
ADDL_STRVG  (P53984), ADD_ECO24   (A7ZM83), ADD_ECO27   (B7URW2), 
ADD_ECO45   (B7M9X6), ADD_ECO55   (B7L5H5), ADD_ECO57   (Q8X661), 
ADD_ECO5E   (B5Z457), ADD_ECO7I   (B7NU11), ADD_ECO81   (B7MVA0), 
ADD_ECO8A   (B7M0H9), ADD_ECOBW   (C4ZY85), ADD_ECODH   (B1XF88), 
ADD_ECOHS   (A8A0G5), ADD_ECOK1   (A1ABG8), ADD_ECOL5   (Q0THK5), 
ADD_ECOL6   (Q8FH99), ADD_ECOLC   (B1IQD2), ADD_ECOLI   (P22333), 
ADD_ECOLU   (B7NB76), ADD_ECOSE   (B6IB57), ADD_ECOSM   (B1LER3), 
ADD_ECOUT   (Q1RBH5), ADD_KLEP3   (B5XWQ7), ADD_KLEP7   (A6T9W8), 
ADD_PHOLL   (Q7N4H5), ADD_PROMH   (B4EVZ1), ADD_SALA4   (B5F6I4), 
ADD_SALDC   (B5FIE1), ADD_SALEP   (B5QUG0), ADD_SALG2   (B5RAJ6), 
ADD_SALHS   (B4THP5), ADD_SALNS   (B4T5A0), ADD_SALPC   (C0Q502), 
ADD_SALSV   (B4TVC7), ADD_SALTI   (Q8Z6R2), ADD_SALTY   (Q8ZPL9), 
ADD_SERP5   (A8GE12), ADD_SHEPC   (A4YCD7), ADD_SHESA   (A0L2R5), 
ADD_SHESM   (Q0HD92), ADD_SHESR   (Q0HPH4), ADD_SHESW   (A1RDZ6), 
ADD_SHIDS   (Q32FF0), ADD_SHIF8   (Q0T4F4), ADD_SHIFL   (Q83RC0), 
ADD_SHISS   (Q3Z1X8), ADD_YERE8   (A1JML4), ADD_YERP3   (A7FHX5), 
ADD_YERPB   (B2K4L5), ADD_YERPS   (Q66AF0), ADD_YERPY   (B1JKL9), 
ADE_ASPFU   (Q4X1Q4), ADE_ASPOR   (Q2TZN9), ADE_CANAL   (Q59ZB1), 
ADE_CANGA   (Q6FP78), ADE_EMENI   (Q8X1T6), ADE_GIBZE   (Q4IMJ1), 
ADE_KLULA   (Q6CM42), ADE_YEAST   (P53909), AMPD1_HUMAN (P23109), 
AMPD1_MOUSE (Q3V1D3), AMPD1_RAT   (P10759), AMPD2_HUMAN (Q01433), 
AMPD2_MOUSE (Q9DBT5), AMPD2_RAT   (Q02356), AMPD3_HUMAN (Q01432), 
AMPD3_MOUSE (O08739), AMPD3_RAT   (O09178), AMPD_ARATH  (O80452), 
AMPD_DICDI  (Q54DD0), AMPD_ORYSJ  (Q84NP7), AMPD_SCHPO  (P50998), 
AMPD_YEAST  (P15274), CADD_LEPIC  (Q72V44)
» more

UniProtKB/Swiss-Prot
False negative sequences		 97 sequences 

ADA2_DANRE  (P58781), ADA2_DICDI  (Q553U5), ADA2_HUMAN  (Q9NZK5), 

ADA2_PIG(P58780), ADA2_PONAB  (Q5RC46), ADA2_XENLA  (Q2VQV9), 
ADALA_XENLA (Q4V831), ADAL_ARATH  (Q8LPL7), ADAL_BOVIN  (Q0VC13), 
ADAL_CAEEL  (Q8IG39), ADAL_DANRE  (Q4V9P6), ADAL_DROME  (Q9VHH7), 
ADAL_DROPS  (Q295P6), ADAL_HUMAN  (Q6DHV7), ADAL_MOUSE  (Q80SY6), 
ADD1_STRCO  (Q9AK25), ADD2_STRCO  (Q9X7T2), ADDL_OPITP  (B1ZYW1), 
ADDL_TREPA  (O83085), ADDL_TREPS  (B2S1Z3), ADD_ALIF1   (Q5E8Q8), 
ADD_ALIFM   (B5FFC4), ADD_CLOAB   (Q97EV1), ADD_CLOB1   (A7FSN7), 
ADD_CLOB6   (C3L357), ADD_CLOBH   (A5I0I2), ADD_CLOBJ   (C1FVJ1), 
ADD_CLOBK   (B1IHX4), ADD_CLOBL   (A7GC28), ADD_CLOBM   (B1KY93), 
ADD_CLOK1   (B9DZX5), ADD_CLOK5   (A5N6F5), ADD_CLOP1   (Q0TME7), 
ADD_CLOPE   (Q8XHH8), ADD_CLOPS   (Q0SQ45), ADD_EDWI9   (C5BDE0), 
ADD_ENT38   (A4W9X4), ADD_ENTFA   (Q839J4), ADD_ERWT9   (B2VK11), 
ADD_HAEDU   (Q7VNV1), ADD_LACCB   (B3W9T6), ADD_LACLA   (Q9CIR9), 
ADD_LACP3   (Q036B8), ADD_MYCA1   (A0QKJ4), ADD_MYCA9   (B1MFZ9), 
ADD_MYCBO   (P63908), ADD_MYCBP   (A1KP00), ADD_MYCGI   (A4TEW1), 
ADD_MYCLB   (B8ZUW8), ADD_MYCLE   (Q9CCL9), ADD_MYCMM   (B2HDU8), 
ADD_MYCPA   (Q73UD0), ADD_MYCSJ   (A3PVY4), ADD_MYCSK   (A1UCA4), 
ADD_MYCSS   (Q1BCN9), ADD_MYCTA   (A5U7Y8), ADD_MYCTU   (P63907), 
ADD_MYCUA   (A0PNJ1), ADD_MYCVP   (A1T5H1), ADD_PECAS   (Q6D4X4), 
ADD_PECCP   (C6DH28), ADD_PSET1   (Q3IF68), ADD_SHEAM   (A1S1P1), 
ADD_SHEB2   (B8EDT7), ADD_SHEB5   (A3CYL9), ADD_SHEB8   (A6WUH7), 
ADD_SHEB9   (A9KWZ3), ADD_SHEDO   (Q12I24), ADD_SHEFN   (Q08A11), 
ADD_SHEHH   (B0TT81), ADD_SHELP   (A3QJD9), ADD_SHEON   (Q8E8D4), 
ADD_SHEPA   (A8H819), ADD_SHEPW   (B8CV32), ADD_SHEWM   (B1KHA6), 
ADD_SHIB3   (B2U2C1), ADD_SHIBS   (Q320Y0), ADD_STRA1   (Q3K2D4), 
ADD_STRA3   (P63909), ADD_STRA5   (P63910), ADD_STRE4   (C0M691), 
ADD_STREM   (B4U295), ADD_STRMU   (Q8DTN8), ADD_STRS7   (C0MHB1), 
ADD_STRT2   (Q5M4W6), ADD_STRTD   (Q03L81), ADD_VIBA3   (B7VQ44), 
ADD_VIBC3   (A5F4Q2), ADD_VIBCH   (Q9KNI7), ADD_VIBCM   (C3LSH8), 
ADD_VIBPA   (Q87TF3), ADD_VIBVU   (Q8D6Q8), ADD_VIBVY   (Q7MDL6), 
AGSA_APLCA  (P15287), MQNX_ACIC1  (A0LRH8), MQNX_STRAW  (Q82K09), 
MQNX_STRCO  (O86737)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 3 sequences 

ADA2_CHICK  (P84520), AMPD1_CHICK (P81073), AMPD1_RABIT (P81072)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			21 sequences
			


			
AGRV1_HUMAN (Q8WXG9), CH60_SYNWW  (Q0AVV1), CYCH_BRADU  (P45399), 

			
GIP3_YEAST  (Q03016), GPL_GLOFF   (Q8MUG0), IPYR1_CHLRE (Q93Y52), 
ISPD_VIBCH  (Q9KUJ2), PURO_NATPD  (Q3ITS6), RTC5_AJECN  (A6RBC0), 
SOMA_SIGGU  (Q9IBE5), SYH_LISIN   (Q92BJ3), SYH_LISMF   (Q71ZF0), 
SYH_LISMO   (Q8Y708), TLN2_HUMAN  (Q9Y4G6), UB10A_XENLA (Q2NL57), 
UB10B_XENLA (Q7ZXR7), UBP10_XENTR (Q6DIJ4), URED_ALKEH  (Q0ACA1), 
YVRB_BACSU  (O34451), ZUPT_XANAC  (Q8PKQ5), ZUPT_XANCP  (Q8P8Z6)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			38 PDB
			


			pdb_00001a4l; pdb_00001a4m; pdb_00001add; pdb_00001krm; pdb_00001ndv; pdb_00001ndw; pdb_00001ndy; pdb_00001ndz; pdb_00001o5r; pdb_00001qxl; pdb_00001uio; pdb_00001uip; 
			
				pdb_00001uml; pdb_00001v79; pdb_00001v7a; pdb_00001vfl; pdb_00001w1i; pdb_00001wxy; pdb_00001wxz; pdb_00002a3l; pdb_00002ada; pdb_00002bgn; pdb_00002e1w; pdb_00002pgf; 
				pdb_00002pgr; pdb_00002qvn; pdb_00002z7g; pdb_00003ewc; pdb_00003ewd; pdb_00003iar; pdb_00003km8; pdb_00003mvi; pdb_00003mvt; pdb_00006ii7; pdb_00006n9m; pdb_00007rtg; 
				pdb_00008hu6; pdb_00008hub
			
			

			» more