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PROSITE documentation PDOC00454 [for PROSITE entry PS00525] |
Ribosomal protein L6 is one of the proteins from the large ribosomal subunit. In Escherichia coli, L6 is known to bind directly to the 23S rRNA and is located at the aminoacyl-tRNA binding site of the peptidyltransferase center. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [1,2,3,4], groups:
While all the above proteins are evolutionary related it is very difficult to derive a pattern that will find them all. We therefore decided to create two patterns, the first to detect eubacterial, cyanelle and mitochondrial L6, the second to detect archaebacterial L6 as well as eukaryotic L9.
Last update:December 2004 / Pattern and text revised.
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PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Suzuki K. Olvera J. Wool I.G. |
Title | The primary structure of rat ribosomal protein L9. | |
Source | Gene 93:297-300(1990). | |
PubMed ID | 2227441 |
2 | Authors | Harrer R. Schwank S. Schueller H.-J. Schweizer E. |
Title | Molecular cloning and analysis of the nuclear gene MRP-L6 coding for a putative mitochondrial ribosomal protein from Saccharomyces cerevisiae. | |
Source | Curr. Genet. 24:136-140(1993). | |
PubMed ID | 8358820 |
3 | Authors | Golden B.L. Ramakrishnan V. White S.W. |
Title | Ribosomal protein L6: structural evidence of gene duplication from a primitive RNA binding protein. | |
Source | EMBO J. 12:4901-4908(1993). | |
PubMed ID | 8262035 |
4 | Authors | Otaka E. Hashimoto T. Mizuta K. Suzuki K. |
Source | Protein Seq. Data Anal. 5:301-313(1993). |