PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00533


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS00533

Direct ScanProsite submission
General information about the entry

Entry name [info] PORPHOBILINOGEN_DEAM
Accession [info] PS00533
Entry type [info] PATTERN
Date [info] 01-DEC-1991 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00461

Name and characterization of the entry

Description [info] Porphobilinogen deaminase cofactor-binding site.
Pattern [info] 
E-[KR]-x-[LIVMFAT]-x(3)-[LIVMFAC]-x-[GSALV]-[GSANHD]-C-x-[IVTACS]-[PLA]-
[LIVMF]-[GSA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 444 in 444 different sequences
Number of true positive hits 444 in 444 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 31
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 93.47 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] cofactor_binding at position 10
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 444 sequences 

HEM31_STRAW (Q82E76), HEM31_STRCO (Q9WX16), HEM32_STRAW (Q82P95), 

HEM32_STRCO (Q9KY00), HEM3_ACIAD  (Q6FFA9), HEM3_ACIC1  (A0LRF1), 
HEM3_ACTSZ  (A6VL87), HEM3_AERPE  (Q9Y9J0), HEM3_AGRFC  (Q8UC46), 
HEM3_ALCBS  (Q0VM28), HEM3_ALIB4  (A8ERI4), HEM3_ALIF1  (Q5E8T5), 
HEM3_ALIFM  (B5FF97), HEM3_ALISL  (B6EPK1), HEM3_ALKEH  (Q0A577), 
HEM3_ALKMQ  (A6TJD5), HEM3_ALKOO  (A8MGE4), HEM3_AQUAE  (O66621), 
HEM3_ARATH  (Q43316), HEM3_ARCFU  (O29026), HEM3_BACAA  (C3P9E9), 
HEM3_BACAC  (C3L6Z5), HEM3_BACAH  (A0RJ81), HEM3_BACAN  (Q81LC7), 
HEM3_BACC0  (B7JQ57), HEM3_BACC1  (Q72ZW2), HEM3_BACC2  (B7IIX5), 
HEM3_BACC3  (C1ETR0), HEM3_BACC4  (B7HE96), HEM3_BACC7  (B7HQM4), 
HEM3_BACCN  (A7GTE5), HEM3_BACCQ  (B9IZ39), HEM3_BACCR  (Q817R0), 
HEM3_BACCZ  (Q633Y0), HEM3_BACHK  (Q6HD62), HEM3_BACLD  (Q65GK1), 
HEM3_BACMK  (A9VIT8), HEM3_BACP2  (A8FFV2), HEM3_BACSU  (P16616), 
HEM3_BACVZ  (A7Z7A5), HEM3_BAUCH  (Q1LU25), HEM3_BORBR  (Q7WKM1), 
HEM3_BORPA  (Q7W785), HEM3_BORPD  (A9IKF3), HEM3_BORPE  (Q7VVU9), 
HEM3_BOVIN  (Q2KIN5), HEM3_BREBN  (C0ZAH1), HEM3_BRUA1  (B2S842), 
HEM3_BRUA2  (Q2YLM5), HEM3_BRUA4  (A6WXJ2), HEM3_BRUAB  (Q57B08), 
HEM3_BRUC2  (A9M8M2), HEM3_BRUMB  (C0RFD1), HEM3_BRUME  (Q8YJB0), 
HEM3_BRUO2  (A5VSL5), HEM3_BRUSI  (B0CID9), HEM3_BRUSU  (Q8FYI6), 
HEM3_BUCA5  (B8D8F3), HEM3_BUCAI  (P57651), HEM3_BUCAT  (B8D8B0), 
HEM3_BURCJ  (B4E8C4), HEM3_BURCM  (Q0BCU9), HEM3_BURM7  (A3MLK5), 
HEM3_BURM9  (A2SAH5), HEM3_BURMA  (Q62LC0), HEM3_BURMS  (A1V5U0), 
HEM3_BURO0  (B1JWR0), HEM3_BURP0  (A3NSN6), HEM3_BURP1  (Q3JUW3), 
HEM3_BURP6  (A3N700), HEM3_BURPS  (Q63W73), HEM3_BURTA  (Q2T071), 
HEM3_BURVG  (A4JGV4), HEM3_CALMQ  (A8MDU3), HEM3_CAMC1  (A7ZD37), 
HEM3_CAMC5  (A7GYU4), HEM3_CAMFF  (A0RNT3), HEM3_CAMHC  (A7I1S0), 
HEM3_CAMJ8  (A8FKW8), HEM3_CAMJD  (A7H4J7), HEM3_CAMJE  (Q9PHW9), 
HEM3_CAMJJ  (A1VYQ4), HEM3_CAMJR  (Q5HVM1), HEM3_CAMLR  (B9KGA9), 
HEM3_CANAL  (O94048), HEM3_CANGA  (Q6FNR4), HEM3_CARHZ  (Q3ACT3), 
HEM3_CAUSK  (B0T287), HEM3_CAUVC  (Q9ABZ8), HEM3_CAUVN  (B8GXG1), 
HEM3_CHLCH  (Q3AQF5), HEM3_CHLL2  (B3EIN1), HEM3_CHLL3  (Q3B2Z5), 
HEM3_CHLP8  (P28464), HEM3_CHLPB  (B3EPK0), HEM3_CHLPD  (A1BHD6), 
HEM3_CHLPM  (A4SFJ8), HEM3_CHLT3  (B3QWI1), HEM3_CHLTE  (Q8KCJ4), 
HEM3_CHRVO  (Q7P207), HEM3_CITBB  (B5EBG8), HEM3_CLOB8  (A6LSY5), 
HEM3_CLOBA  (B2UXC4), HEM3_CLOBB  (B2TPD7), HEM3_CLOD6  (Q180R9), 
HEM3_CLOK1  (B9DZL6), HEM3_CLONN  (A0Q2B1), HEM3_CLOP1  (Q0TQG4), 
HEM3_CLOPE  (Q8XKG4), HEM3_CLOPS  (Q0ST16), HEM3_COLP3  (Q48AW8), 
HEM3_CORA7  (C3PKG2), HEM3_CORDI  (Q6NJK0), HEM3_COREF  (Q8FSF7), 
HEM3_CORGB  (A4QB59), HEM3_CORGL  (Q8NT90), HEM3_COXB1  (B6J6K0), 
HEM3_COXB2  (B6J3T6), HEM3_COXBN  (A9KDC4), HEM3_COXBR  (A9N910), 
HEM3_COXBU  (Q83A37), HEM3_CROS8  (A7MQJ1), HEM3_CUTAK  (Q6AB05), 
HEM3_DEBHA  (Q6BM23), HEM3_DECAR  (Q479S8), HEM3_DEIDV  (C1CYD9), 
HEM3_DEIGD  (Q1J288), HEM3_DEIRA  (Q9RRY0), HEM3_DESAP  (B1I4L8), 
HEM3_DESHD  (B8G2M2), HEM3_DESHY  (Q24VC8), HEM3_DESRM  (A4J6H7), 
HEM3_DICDI  (Q54P93), HEM3_DICNV  (A5EW83), HEM3_ECO45  (B7MH66), 
HEM3_ECO55  (B7L959), HEM3_ECO57  (Q8XAP3), HEM3_ECO7I  (B7NTE0), 
HEM3_ECO81  (B7N295), HEM3_ECO8A  (B7M603), HEM3_ECOBW  (C4ZZ69), 
HEM3_ECODH  (B1XAH2), HEM3_ECOL6  (Q8FBP1), HEM3_ECOLI  (P06983), 
HEM3_ECOLU  (B7NFA7), HEM3_ECOSE  (B6I4E0), HEM3_EHRCJ  (Q3YSA8), 
HEM3_EHRCR  (Q2GGC7), HEM3_ENT38  (A4WG12), HEM3_EREGS  (Q75DY0), 
HEM3_ERWT9  (B2VG55), HEM3_ESCF3  (B7LU53), HEM3_EUGGR  (P13446), 
HEM3_EXIS2  (B1YJV1), HEM3_EXISA  (C4L4J6), HEM3_FRAP2  (B0TW04), 
HEM3_FRAT1  (Q14JI3), HEM3_FRATF  (A7N9H6), HEM3_FRATH  (Q2A5R3), 
HEM3_FRATM  (B2SE34), HEM3_FRATN  (A0Q481), HEM3_FRATO  (Q0BP15), 
HEM3_FRATT  (Q5NI31), HEM3_FRATW  (A4IZY4), HEM3_FUSNN  (Q8RFP5), 
HEM3_GEODF  (B9M416), HEM3_GEOKA  (Q5KWK6), HEM3_GEOMG  (Q39QM7), 
HEM3_GEOSL  (Q747I1), HEM3_GEOSM  (C6DYY8), HEM3_GEOSW  (C5D5K7), 
HEM3_GEOTN  (A4IRG5), HEM3_GEOUR  (A5GCW2), HEM3_GLOVI  (Q7NGF7), 
HEM3_HAHCH  (Q2SQ70), HEM3_HALH5  (Q9K8G0), HEM3_HALHL  (A1WVT9), 
HEM3_HALSA  (Q9HMY5), HEM3_HAMD5  (C4K4E3), HEM3_HELAH  (Q17W61), 
HEM3_HELHP  (Q7VFE9), HEM3_HELP2  (B6JKG8), HEM3_HELPG  (B5ZA04), 
HEM3_HELPH  (Q1CUR5), HEM3_HELPJ  (Q9ZMJ7), HEM3_HELPS  (B2US69), 
HEM3_HELPY  (P56140), HEM3_HISS1  (Q0I178), HEM3_HISS2  (B0UWZ8), 
HEM3_HUMAN  (P08397), HEM3_HYDCU  (Q31JG5), HEM3_HYPBU  (A2BL26), 
HEM3_HYPNA  (Q0BX92), HEM3_IDILO  (Q5QUS3), HEM3_IGNH4  (A8AAB4), 
HEM3_KLEP3  (B5XYL1), HEM3_KLEP7  (A6TGI8), HEM3_KLULA  (Q6CT60), 
HEM3_KORVE  (Q1INI6), HEM3_LARHH  (C1D679), HEM3_LAWIP  (Q1MPL2), 
HEM3_LEGPA  (Q5X1F2), HEM3_LEGPH  (Q5ZRY6), HEM3_LEGPL  (Q5WT65), 
HEM3_LEIXX  (Q6AHF1), HEM3_LISIN  (Q92BF8), HEM3_LISMC  (C1KVK3), 
HEM3_LISMF  (Q71ZB2), HEM3_LISMH  (B8DHJ2), HEM3_LISMO  (Q8Y6X5), 
HEM3_LISW6  (A0AJ05), HEM3_LYSSC  (B1HVD6), HEM3_MACCJ  (B9E743), 
HEM3_MANSM  (Q65VX7), HEM3_MARN8  (A1TXW9), HEM3_MARSD  (C6BYB7), 
HEM3_METAC  (Q8TT56), HEM3_METAR  (Q0W5T2), HEM3_METBF  (Q46CH0), 
HEM3_METBU  (Q12WM8), HEM3_METCA  (Q602K3), HEM3_METFK  (Q1GXA1), 
HEM3_METJA  (Q57989), HEM3_METMA  (Q8PW57), HEM3_METS5  (A4YD92), 
HEM3_METTH  (O26960), HEM3_MICLC  (C5CB88), HEM3_MOUSE  (P22907), 
HEM3_MYCA1  (A0QLI0), HEM3_MYCA9  (B1MHI5), HEM3_MYCBO  (P64337), 
HEM3_MYCBP  (A1KFY6), HEM3_MYCBT  (C1AKJ0), HEM3_MYCGI  (A4T340), 
HEM3_MYCLE  (Q49808), HEM3_MYCMM  (B2HRJ2), HEM3_MYCPA  (Q73SS0), 
HEM3_MYCTA  (A5TZP0), HEM3_MYCTO  (P9WMP2), HEM3_MYCTU  (P9WMP3), 
HEM3_MYCUA  (A0PW29), HEM3_MYCVP  (A1T3D3), HEM3_MYXXD  (Q1D8Z8), 
HEM3_NATTJ  (B2A1G7), HEM3_NEIMA  (Q9JVS4), HEM3_NEIMB  (Q9K0P6), 
HEM3_NEUCR  (Q6MW51), HEM3_NITEU  (Q82WS2), HEM3_NITHX  (Q1QQP5), 
HEM3_NITSB  (A6Q3S1), HEM3_NITV2  (Q72AV0), HEM3_NITV4  (A1VCX6), 
HEM3_NITV9  (B8DKW2), HEM3_NITWN  (Q3SVF3), HEM3_NOCFA  (Q5YP70), 
HEM3_NOSS1  (Q8YVU6), HEM3_OCEIH  (Q8CXC0), HEM3_OLEA2  (Q30Y29), 
HEM3_ORYSJ  (Q6H6D2), HEM3_PAEMA  (O69110), HEM3_PARDP  (A1B853), 
HEM3_PARMW  (Q7U5C2), HEM3_PARP8  (B2JEN9), HEM3_PARPJ  (B2T1D1), 
HEM3_PASMU  (Q9CK24), HEM3_PEA(Q43082), HEM3_PECAS  (Q6CZG3), 
HEM3_PECCP  (C6DHC2), HEM3_PELPB  (B4SFI2), HEM3_PELPD  (A1AUE7), 
HEM3_PELTS  (A5D3L5), HEM3_PHEZH  (B4RC21), HEM3_PHOLL  (Q7MYN1), 
HEM3_PROA2  (B4S922), HEM3_PROM0  (A3PBM0), HEM3_PROM1  (A2C0V4), 
HEM3_PROM2  (A8G3L1), HEM3_PROM3  (A2C7L8), HEM3_PROM4  (A9BEB6), 
HEM3_PROM5  (A2BVF7), HEM3_PROM9  (Q31C38), HEM3_PROMA  (Q7VD89), 
HEM3_PROMH  (B4F1X3), HEM3_PROMI  (Q59684), HEM3_PROMM  (Q7V697), 
HEM3_PROMP  (Q7V2I1), HEM3_PROMS  (A2BPX7), HEM3_PROMT  (Q46GS7), 
HEM3_PSEA6  (Q15Z15), HEM3_PSEA8  (B7V5F0), HEM3_PSEAB  (Q02EA3), 
HEM3_PSEAE  (Q60169), HEM3_PSEE4  (Q1I316), HEM3_PSEF5  (Q4K3X3), 
HEM3_PSEFS  (C3K424), HEM3_PSEP1  (A5VWX3), HEM3_PSEP7  (A6VE37), 
HEM3_PSEPF  (Q3K4T0), HEM3_PSEPG  (B0KH05), HEM3_PSEPK  (Q88RE5), 
HEM3_PSEPW  (B1J1V2), HEM3_PSESM  (Q88B91), HEM3_PSEU2  (Q500N6), 
HEM3_PSYIN  (A1T0R0), HEM3_PYRAE  (Q8ZYW7), HEM3_PYRAR  (A4WN24), 
HEM3_PYRCJ  (A3MWV7), HEM3_PYRIL  (A1RQK2), HEM3_PYRNV  (B1YDP0), 
HEM3_RALN1  (Q8XWW3), HEM3_RAT(P19356), HEM3_RHILO  (Q98EI7), 
HEM3_RHIME  (Q92LH7), HEM3_RHOBA  (Q7UPN0), HEM3_RICAE  (C3PNS9), 
HEM3_RICAH  (A8GNR5), HEM3_RICB8  (A8GXC8), HEM3_RICBR  (Q1RJN7), 
HEM3_RICCK  (A8EYJ9), HEM3_RICCN  (Q92HR5), HEM3_RICFE  (Q4ULA5), 
HEM3_RICM5  (A8F1Y8), HEM3_RICPR  (Q9ZD77), HEM3_RICPU  (C4K265), 
HEM3_RICRO  (B0BY00), HEM3_RICRS  (A8GSI6), HEM3_RICTY  (Q68WR3), 
HEM3_ROSCS  (A7NKU8), HEM3_ROSS1  (A5UU37), HEM3_RUBXD  (Q1AUK3), 
HEM3_RUMCH  (B8I0Q8), HEM3_RUMJO  (Q59293), HEM3_RUTMC  (A1AX51), 
HEM3_SACI1  (C3NF70), HEM3_SACI2  (C3MJ21), HEM3_SACI3  (C3MZR8), 
HEM3_SACI4  (C3MYD9), HEM3_SACI6  (C4KIZ9), HEM3_SACI7  (C3N841), 
HEM3_SACS2  (Q980U4), HEM3_SALAR  (A9MJ10), HEM3_SALDC  (B5FN93), 
HEM3_SALPA  (Q5PKL7), HEM3_SALPC  (C0Q3B3), HEM3_SALPK  (B5BIU8), 
HEM3_SALSV  (B4TNV3), HEM3_SALTI  (P0A1Q9), HEM3_SALTY  (P0A1Q8), 
HEM3_SCHPO  (Q09899), HEM3_SERP5  (A8G848), HEM3_SHEB2  (B8E879), 
HEM3_SHEB5  (A3D9Q4), HEM3_SHEB8  (A6WTG0), HEM3_SHEB9  (A9L5G0), 
HEM3_SHEFN  (Q088L3), HEM3_SHEHH  (B0TJ54), HEM3_SHEON  (Q8E9H0), 
HEM3_SHEPA  (A8GZG4), HEM3_SHEPC  (A4YBG2), HEM3_SHESA  (A0KS60), 
HEM3_SHESH  (A8G0W4), HEM3_SHESM  (Q0HN99), HEM3_SHESR  (Q0HQI7), 
HEM3_SHESW  (A1RPD7), HEM3_SHEWM  (B1KQC6), HEM3_SHIFL  (Q83PH4), 
HEM3_SHOC1  (Q5WEP5), HEM3_SORC5  (A9FDP9), HEM3_SPHAL  (Q1GP41), 
HEM3_STAA1  (A7X391), HEM3_STAA2  (A6U2D8), HEM3_STAA3  (Q2FG66), 
HEM3_STAA8  (O34090), HEM3_STAA9  (A5ITJ5), HEM3_STAAB  (Q2YTB9), 
HEM3_STAAC  (Q5HFA2), HEM3_STAAE  (A6QHK4), HEM3_STAAM  (P64340), 
HEM3_STAAN  (P64341), HEM3_STAAR  (Q6GG35), HEM3_STAAS  (Q6G8Q5), 
HEM3_STAAT  (A8Z2J1), HEM3_STAAW  (Q8NW74), HEM3_STACT  (B9DNE1), 
HEM3_STAEQ  (Q5HNN3), HEM3_STAES  (Q8CNY8), HEM3_STAHJ  (Q4L709), 
HEM3_STAS1  (Q49YA2), HEM3_STRM5  (B4SJT8), HEM3_STRMK  (B2FI06), 
HEM3_SULDN  (Q30S90), HEM3_SULNB  (A6Q7Y4), HEM3_SULTO  (Q976H1), 
HEM3_SYNC1  (Q3A009), HEM3_SYNE7  (Q31PM2), HEM3_SYNFM  (A0LN73), 
HEM3_SYNR3  (A5GSE0), HEM3_SYNS3  (Q0I8I3), HEM3_SYNS9  (Q3AWQ4), 
HEM3_SYNSC  (Q3ALS9), HEM3_SYNWW  (Q0AZ43), HEM3_SYNY3  (P73660), 
HEM3_THEAC  (Q9HKM5), HEM3_THEFY  (Q47LA7), HEM3_THET2  (Q72H57), 
HEM3_THET8  (Q5SLE8), HEM3_THEVB  (Q8DIE4), HEM3_THEVO  (Q97B26), 
HEM3_THIDA  (Q3SFT5), HEM3_THISH  (B8GSU8), HEM3_TRIL1  (B3E2H7), 
HEM3_VESOH  (A5CW34), HEM3_VIBA3  (B7VMD9), HEM3_VIBC1  (A7MXU9), 
HEM3_VIBCH  (Q9KVM1), HEM3_VIBPA  (Q87KI9), HEM3_VIBVU  (Q8DD85), 
HEM3_VIBVY  (Q7MQC7), HEM3_WOLSU  (Q7M8L2), HEM3_WOLWR  (C0R2M3), 
HEM3_XANAC  (Q8PPR3), HEM3_XANC8  (Q4UYZ4), HEM3_XANCB  (B0RNI9), 
HEM3_XANCP  (Q8P536), HEM3_XANE5  (Q3BXV3), HEM3_XANOM  (Q2NYU4), 
HEM3_XANOP  (B2SMV3), HEM3_XANOR  (Q5GVL2), HEM3_XYLF2  (B2I5K8), 
HEM3_XYLFA  (Q9PCX7), HEM3_XYLFM  (B0U2W8), HEM3_XYLFT  (Q87CC9), 
HEM3_YARLI  (Q6C097), HEM3_YEAST  (P28789), HEM3_YERE8  (A1JI86), 
HEM3_YERP3  (A7FD67), HEM3_YERPA  (Q1CBN1), HEM3_YERPB  (B2K065), 
HEM3_YERPE  (P46355), HEM3_YERPG  (A9R8K0), HEM3_YERPN  (Q1CNI3), 
HEM3_YERPP  (A4TRA8), HEM3_YERPS  (Q66G00), HEM3_YERPY  (B1JPE6)
» more

UniProtKB/Swiss-Prot
False negative sequences		 31 sequences 

HEM3_ACET2  (A3DIF0), HEM3_ACIF2  (B7JBH8), HEM3_ACIF5  (B5ERN6), 

HEM3_ALBFT  (Q21XQ9), HEM3_BLOFL  (Q7VRM4), HEM3_BLOPB  (Q491Z6), 
HEM3_CALS8  (A4XK06), HEM3_CHLMU  (Q9PK95), HEM3_CHLPN  (Q9Z9C9), 
HEM3_CHLTR  (O84301), HEM3_CLOAB  (Q97MU4), HEM3_CLOB1  (A7FSG8), 
HEM3_CLOB6  (C3L2Z3), HEM3_CLOBH  (A5I0B2), HEM3_CLOBJ  (C1FVB9), 
HEM3_CLOBK  (B1IHD1), HEM3_CLOBL  (A7GBW3), HEM3_CLOBM  (B1KY15), 
HEM3_CYTH3  (Q11XT5), HEM3_DESOH  (A8ZWG5), HEM3_LACE2  (C4Z552), 
HEM3_LIMRD  (A5VM67), HEM3_LIMRJ  (B2G9H4), HEM3_METKA  (Q8TXC8), 
HEM3_MOOTA  (Q2RJ26), HEM3_NITMS  (A9A1A1), HEM3_ORITB  (A5CDH4), 
HEM3_ORITI  (B3CUP9), HEM3_PICTO  (Q6L2G8), HEM3_STRSV  (A3CL78), 
HEM3_SYNAS  (Q2LQU2)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

HEM3_DICCH  (P40129), HEM3_YERIN  (P30527)


				
	

	

		PDB
[Detailed view]		
		
			18 PDB
			


			pdb_00001ah5; pdb_00001gtk; pdb_00001pda; pdb_00001ypn; pdb_00002ypn; pdb_00003ecr; pdb_00003eq1; pdb_00004htg; pdb_00005h6o; pdb_00005m6r; pdb_00005m7f; pdb_00007aaj; 
			
				pdb_00007aak; pdb_00007ccx; pdb_00007ccy; pdb_00007ccz; pdb_00007cd0; pdb_00008pnd
			
			

			» more