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PROSITE documentation PDOC00468 [for PROSITE entry PS00542] |
Respiratory-chain NADH dehydrogenase (EC 1.6.5.3) [1,2] (also known as complex I or NADH-ubiquinone oxidoreductase) is an oligomeric enzymatic complex located in the inner mitochondrial membrane which also seems to exist in the chloroplast and in cyanobacteria (as a NADH-plastoquinone oxidoreductase). Among the 25 to 30 polypeptide subunits of this bioenergetic enzyme complex there is one with a molecular weight of 30 Kd (in mammals) which has been found to be:
It is also present in bacteria:
This protein, in its mature form, consists of from 157 to 266 amino acid residues. The best conserved region is located in the C-terminal section and can be used as a signature pattern.
Last update:December 2001 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Ragan C.I. |
Source | Curr. Top. Bioenerg. 15:1-36(1987). |
2 | Authors | Weiss H. Friedrich T. Hofhaus G. Preis D. |
Title | The respiratory-chain NADH dehydrogenase (complex I) of mitochondria. | |
Source | Eur. J. Biochem. 197:563-576(1991). | |
PubMed ID | 2029890 |