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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00622


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PURL: https://purl.expasy.org/prosite/signature/PS00622

Direct ScanProsite submission
General information about the entry

Entry name [info] HTH_LUXR_1
Accession [info] PS00622
Entry type [info] PATTERN
Date [info] 01-JUN-1992 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00542

Name and characterization of the entry

Description [info] LuxR-type HTH domain signature.
Pattern [info] 
[GDC]-x(2)-[NSTAVY]-x(2)-[IV]-[GSTA]-x(2)-[LIVMFYWCT]-x-[LIVMFYWCR]-x(3)-
[NST]-[LIVM]-x(2)-{T}-x(2)-[NRHSA]-[LIVMSTA]-x(2)-[KR].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 190 in 190 different sequences
Number of true positive hits 175 in 175 different sequences
Number of 'unknown' hits 0
Number of false positive hits 15 in 15 different sequences
Number of false negative sequences 77
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 92.11 %
Recall (true positives / (true positives + false negatives)) 69.44 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 175 sequences 

AGMR_PSEAE  (P29369), AGMR_PSEPU  (A8R3T0), ANOR_ACINO  (A0A0N8YGA2), 

BVGA_BORBR  (P0A4H3), BVGA_BORPA  (P0A4H4), BVGA_BORPE  (P0A4H2), 
CARR_PECCC  (Q46751), CMPA_BACSU  (P14204), CSGD_ECOLI  (P52106), 
CSGD_SALTY  (O54294), DCTR_RHOCA  (P37740), DEGU_BACSU  (P13800), 
DEGU_BREBE  (P54662), DEVR_MYCTO  (P9WMF8), DEVR_MYCTU  (P9WMF9), 
ECHR_DICCH  (Q46967), ECNR_CITFR  (O69280), ESAR_PANSE  (P54293), 
EVGA_ECO57  (P0ACZ6), EVGA_ECOL6  (P0ACZ5), EVGA_ECOLI  (P0ACZ4), 
EVGA_SHIFL  (P0ACZ7), EXPR_DICD3  (Q47188), EXPR_PECPM  (Q47189), 
FIMZ_ECO57  (P0AEL9), FIMZ_ECOLI  (P0AEL8), FIMZ_SALTY  (P26319), 
FIXJ_AZOC5  (P26487), FIXJ_BRADU  (P23221), FIXJ_RHIME  (P10958), 
GACA_PSEAE  (Q51373), GACA_PSEPH  (P32967), GACA_PSEU2  (Q52376), 
GACA_PSEVI  (P95582), GERE_BACSU  (P11470), GFSR_STRHA  (E0D209), 
LASR_PSEAE  (P25084), LIAR_BACSU  (O32197), LNRK_BACSU  (P94439), 
LUXR_ALIFS  (P12746), LUXS_ALIF1  (P35327), MALT_CITK8  (A8AQX2), 
MALT_CROS8  (A7ME76), MALT_ECO24  (A7ZSU8), MALT_ECO27  (B7UKC3), 
MALT_ECO45  (B7MDP4), MALT_ECO55  (B7L4U8), MALT_ECO57  (Q8X701), 
MALT_ECO5E  (B5YTW9), MALT_ECO7I  (B7NMI3), MALT_ECO81  (B7N1J6), 
MALT_ECO8A  (B7M2H9), MALT_ECOBW  (C4ZVX0), MALT_ECODH  (B1X764), 
MALT_ECOHS  (A8A5M7), MALT_ECOK1  (A1AGU2), MALT_ECOL5  (Q0TC49), 
MALT_ECOL6  (Q8CXX5), MALT_ECOLC  (B1IP47), MALT_ECOLI  (P06993), 
MALT_ECOLU  (B7NE23), MALT_ECOSE  (B6I2Y2), MALT_ECOSM  (B1LI79), 
MALT_ECOUT  (Q1R5L6), MALT_ENT38  (A4WFK6), MALT_ESCF3  (B7LSC1), 
MALT_KLEP3  (B5XTR7), MALT_KLEP7  (A6TF41), MALT_PHOLL  (Q7N976), 
MALT_SALA4  (B5F8N2), MALT_SALAR  (A9MMA9), MALT_SALCH  (Q57IV9), 
MALT_SALDC  (B5FKD6), MALT_SALEP  (B5R375), MALT_SALG2  (B5R7J9), 
MALT_SALHS  (B4TKU2), MALT_SALNS  (B4SVL9), MALT_SALPA  (Q5PM00), 
MALT_SALPB  (A9MTT7), MALT_SALPK  (B5BHH3), MALT_SALSV  (B4TY75), 
MALT_SALTI  (Q8Z227), MALT_SALTY  (Q8ZLI3), MALT_SERP5  (A8GKU0), 
MALT_SHIBS  (Q31VL4), MALT_SHIF8  (Q0SZP7), MALT_SHISS  (Q3YWK7), 
MALT_VIBC1  (A7N5N6), MALT_VIBCH  (Q9KNF3), MALT_VIBPA  (Q87FQ5), 
MALT_VIBVU  (Q8D4P3), MALT_VIBVY  (Q7MG94), MALT_YERE8  (A1JSF2), 
MALT_YERP3  (A7FNW4), MALT_YERPA  (Q1C2L4), MALT_YERPB  (B2K5W2), 
MALT_YERPE  (Q8ZJI2), MALT_YERPP  (A4TGR4), MALT_YERPS  (Q664J3), 
MALT_YERPY  (B1JHZ0), MOAR_KLEAE  (P54794), NARL_ECO57  (P0AF30), 
NARL_ECOL6  (P0AF29), NARL_ECOLI  (P0AF28), NARL_SHIFL  (P0AF31), 
NARP_ECOLI  (P31802), NARP_HAEIN  (P44845), NODW_BRADU  (P15940), 
NREC_STAA1  (A7X623), NREC_STAA2  (A6U4C0), NREC_STAA3  (Q2FEA6), 
NREC_STAA8  (Q2FVM7), NREC_STAA9  (A5IVH2), NREC_STAAB  (Q2YZ42), 
NREC_STAAC  (Q5HDG5), NREC_STAAE  (A6QJN1), NREC_STAAM  (Q99RN8), 
NREC_STAAN  (Q7A3U5), NREC_STAAR  (Q6GE42), NREC_STAAS  (Q6G6T0), 
NREC_STAAT  (A8Z580), NREC_STAAW  (Q7A029), NREC_STACT  (Q7WZY4), 
NREC_STAEQ  (Q5HLK6), NREC_STAES  (Q8CN75), NREC_STAHJ  (Q4L8Q6), 
PHZR_PSECL  (P54303), PHZR_PSEFL  (Q51786), RCSA_ECO57  (P69406), 
RCSA_ECOLI  (P0DMC9), RCSA_ECOLX  (P0DMD0), RCSA_ERWAM  (P20098), 
RCSA_KLEAE  (P05338), RCSA_PANSE  (P27488), RCSA_SALTI  (Q56083), 
RCSA_SALTY  (P54698), RCSB_ECO57  (P69409), RCSB_ECOL6  (P69408), 
RCSB_ECOLI  (P0DMC7), RCSB_ECOLX  (P0DMC8), RCSB_SALTI  (Q56127), 
RCSB_SALTY  (P58663), RCSB_SHIFL  (P69410), RHIR_RHILV  (Q03316), 
RHLR_PSEAE  (P54292), SDIA_ECOLI  (P07026), SGAR_HYPME  (P56644), 
SOLR_RALN1  (P58590), SOLR_RALSL  (O30919), SSRB_SALTY  (Q7CQM5), 
TDIR_THAAR  (O87940), THAA_BURTA  (Q2T4M4), TRPO_PSEAE  (P24908), 
TTRR_SALTY  (Q7CQM8), UHPA_ECO57  (P0AGA8), UHPA_ECOL6  (P0AGA7), 
UHPA_ECOLI  (P0AGA6), UHPA_SALTY  (P27667), UHPA_SHIFL  (P0AGA9), 
UVRY_ECO57  (P66798), UVRY_ECOL6  (P66797), UVRY_ECOLI  (P0AED5), 
UVRY_SHIFL  (P0AED6), Y4QH_SINFN  (P55629), Y890_MYCTO  (P9WMG0), 
Y890_MYCTU  (P9WMG1), Y914_MYCBO  (P59969), YDFI_BACSU  (P96686), 
YENR_YEREN  (P54295), YEXN_AERSA  (P45785), YGEK_ECO57  (P58664), 
YGEK_ECOLI  (Q46791), YHCZ_BACSU  (O07528), YHJB_ECOLI  (P37640), 
YXJL_BACSU  (P55184)
» more

UniProtKB/Swiss-Prot
False negative sequences		 77 sequences 

AHYR_AERHY  (P0A3J5), ALKS_ALCBS  (Q0VKZ4), ALKS_ECTOL  (P17051), 

ALKS_PSEPU  (Q9L4M7), ASAR_AERSA  (P0A3J6), BGLJ_ECOLI  (P39404), 
BJAR1_BRADU (Q89VI3), BRPA_STRHY  (Q01108), DCTR_ECO57  (Q8X5P3), 
DCTR_ECOL6  (Q8FCK2), DCTR_ECOLI  (P37195), DCTR_SHIFL  (Q83J60), 
DESR_BACSU  (O34723), ECPR_ECO24  (A7ZI28), ECPR_ECO27  (B7UJE2), 
ECPR_ECO55  (B7L425), ECPR_ECO57  (Q8X6I1), ECPR_ECO5E  (B5Z1N3), 
ECPR_ECO81  (B7MP71), ECPR_ECODH  (B1XE36), ECPR_ECOHS  (A7ZWT2), 
ECPR_ECOK1  (A1A7X7), ECPR_ECOKI  (Q9AME2), ECPR_ECOL5  (Q0TKZ0), 
ECPR_ECOL6  (Q8FKL2), ECPR_ECOLC  (B1J0X8), ECPR_ECOLI  (P71301), 
ECPR_ECOLU  (B7N8J2), ECPR_ECOSE  (B6I082), ECPR_ECOSM  (B1LHW0), 
ECPR_ECOUT  (Q1RFQ3), ECPR_KLEP3  (B5Y159), ECPR_KLEP7  (A6T571), 
ECPR_SHIBS  (Q325R5), EXAE_PSEPU  (A8R3S7), GADE_ECO57  (P63206), 
GADE_ECOL6  (P63205), GADE_ECOLI  (P63204), GADE_SHIFL  (P63207), 
MCTR_RHIJ3  (Q1M7A0), MOXX_PARDE  (P29904), NARL_MYCTO  (P9WGM4), 
NARL_MYCTU  (P9WGM5), RAIR_RHIET  (O54452), RPAR_RHOPA  (Q6NCZ5), 
TMOT_ECTME  (Q8KR08), TODT_PSEP1  (A5W4E2), TODT_PSEPT  (I7CA98), 
TODT_PSEPU  (Q3LWR6), TRAR_AGRFC  (P54294), TRAR_AGRVI  (P33909), 
TRAR_RHIRD  (P33905), TRAR_SINFN  (P55407), VANR_VIBAN  (P74946), 
VJBR_BRUA2  (Q2YJ50), VJBR_BRUAB  (Q579W9), VJBR_BRUME  (Q8YAY5), 
VJBR_BRUO2  (A5VTN1), VJBR_BRUSU  (Q8FXF9), VRAR_STAA1  (P0C0Z1), 
VRAR_STAAC  (Q5HEP0), VRAR_STAAM  (Q7A2Q1), VRAR_STAAN  (Q7A4R9), 
VRAR_STAAR  (Q6GFH3), VRAR_STAAS  (Q6G850), VRAR_STAAW  (Q7A0I0), 
VRAR_STAEQ  (Q5HN50), VRAR_STAES  (Q8CNP9), VRAR_STAHJ  (Q4L7J5), 
VRAR_STAS1  (Q49YS9), YCF29_CYAPA (P48359), YCF29_GUITH (O78417), 
YCF29_PORPU (P51343), YCF29_PYRYE (Q1XDE4), YJJQ_ECOLI  (P0ADD7), 
YUAB_ECOLI  (Q9JMT8), YUKR_YERRU  (O87971)
» more

UniProtKB/Swiss-Prot
False positive sequences		 15 sequences 

ANS1B_DANRE (A5PMU4), GLMU_STAA3  (Q2FJE2), GLMU_STAA8  (Q2G0S3), 

GLMU_STAAB  (Q2YVU6), GLMU_STAAC  (Q5HIH6), GLMU_STAAM  (Q99WA4), 
GLMU_STAAN  (Q7A7B4), GLMU_STAAR  (Q6GJH2), GLMU_STAAS  (Q6GBY9), 
GLMU_STAAW  (Q8NXZ7), K1549_HUMAN (Q9HCM3), K1549_MOUSE (Q68FD9), 
RPSH_BACLI  (P02964), RPSH_BACSU  (P17869), Y170_LACJO  (P60951)
» more

PDB
[Detailed view]		 39 PDB

pdb_00001a04; pdb_00001fse; pdb_00001je8; pdb_00001rnl; pdb_00001x3u; pdb_00001zg1; pdb_00001zg5; pdb_00001zlj; pdb_00001zlk; pdb_00002krf; pdb_00003c3w; pdb_00003c57; pdb_00003ulq; pdb_00004lfu; pdb_00004lgw; pdb_00005f64; pdb_00005o8y; pdb_00005o8z; pdb_00005vxn; pdb_00005w43; pdb_00006eo2; pdb_00006eo3; pdb_00006mwh; pdb_00006mwl; pdb_00006mww; pdb_00006mwz; pdb_00006v7w; pdb_00006v7x; pdb_00006zix; pdb_00006zj2; pdb_00007r3e; pdb_00007r3g; pdb_00007r3h; pdb_00007r3i; pdb_00007r3j; pdb_00008b4a; pdb_00008dq0; pdb_00008dq1; pdb_00008u3b
» more