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PROSITE documentation PDOC00554 [for PROSITE entry PS00643]

Respiratory-chain NADH dehydrogenase 75 Kd subunit signatures





Description

Respiratory-chain NADH dehydrogenase (EC 1.6.5.3) [1,2] (also known as complex I or NADH-ubiquinone oxidoreductase) is an oligomeric enzymatic complex located in the inner mitochondrial membrane which also seems to exist in the chloroplast and in cyanobacteria (as a NADH-plastoquinone oxidoreductase). Among the 25 to 30 polypeptide subunits of this bioenergetic enzyme complex there is one with a molecular weight of 75 Kd (in mammals), which is the largest subunit of complex I and is a component of the iron-sulfur (IP) fragment of the enzyme. It seems to bind to two 4Fe-4S clusters (called N-3 and N-4).

The 75 Kd subunit is highly similar to [3,4]:

The 75 Kd subunit and the bacterial hydrogenase γ subunit contains three conserved clusters of cysteine residues which are most probably involved in the binding of the iron-sulfur clusters. We have developed signature patterns for these three regions.

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Last update:

December 2004 / Pattern and text revised.

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Technical section

PROSITE methods (with tools and information) covered by this documentation:

?, PS00643;   (?)

COMPLEX1_75K_1, PS00641; Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1  (PATTERN)

COMPLEX1_75K_2, PS00642; Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2  (PATTERN)


Reference



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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