We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE entry PS00671
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PURL: https://purl.expasy.org/prosite/signature/PS00671
Direct ScanProsite submission
General information about the entry
| Entry name [info] | D_2_HYDROXYACID_DH_3 |
| Accession [info] | PS00671 |
| Entry type [info] | PATTERN |
| Date [info] |
01-JUN-1992 CREATED;
01-APR-2006 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00063 |
Name and characterization of the entry
| Description [info] | D-isomer specific 2-hydroxyacid dehydrogenases signature 3. |
| Pattern [info] |
[LMFATCYV]-[KPQNHAR]-x-[GSTDNK]-x-[LIVMFYWRC]-[LIVMFYW](2)-N-x-[STAGC]-R- [GP]-x-[LIVH]-[LIVMCT]-[DNVE]. |
Numerical results [info]
| Total number of hits | 333 in 333 different sequences |
| Number of true positive hits | 332 in 332 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 1 |
| Number of false negative sequences | 69 |
| Number of 'partial' sequences | 1 |
| Precision (true positives / (true positives + false positives)) | 99.70 % |
| Recall (true positives / (true positives + false negatives)) | 82.79 % |
Comments [info]
| Taxonomic range [info] | Archaea, Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 1 |
| Version [info] | 2 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
332 sequences
CTBP1_HUMAN (Q13363), CTBP1_MOUSE (O88712), CTBP1_RAT (Q9Z2F5), CTBP1_XENLA (Q9YHU0), CTBP2_BOVIN (Q0VCQ1), CTBP2_HUMAN (P56545), CTBP2_MOUSE (P56546), CTBP2_RAT (Q9EQH5), CTBP2_XENLA (Q9W758), CTBP_DROME (O46036), DDH_HAEIN (P44501), DDH_ZYMMO (P30799), DHD2_LACPA (P17584), DHGY_CUCSA (P13443), DHGY_HYPME (P36234), DHGY_METEA (Q59516), EFUE_HORCR (A0A2Z4HPZ6), FDH1_ORYSJ (Q9SXP2), FDH1_YEAS7 (A6ZN46), FDH1_YEAS8 (C8ZHD6), FDH1_YEASC (N1P3Y5), FDH1_YEAST (Q08911), FDH2_YEASC (P0CT22), FDH2_YEAST (P0CF35), FDH_ARATH (Q9S7E4), FDH_CANBO (O13437), FDH_CHATD (G0SGU4), FDH_EMENI (Q03134), FDH_HORVU (Q9ZRI8), FDH_NEUCR (Q07103), FDH_PICAN (P33677), FDH_PSESR (P33160), FDH_SOLTU (Q07511), FLDH_CLOS1 (J7SHB8), FLDH_CLOS3 (G9EZR6), GHRA_CITK8 (A8AI49), GHRA_CROS8 (A7MFZ8), GHRA_ECO27 (B7UP47), GHRA_ECO45 (B7MIH3), GHRA_ECO55 (B7LFE3), GHRA_ECO57 (Q8X9K1), GHRA_ECO5E (B5YVQ3), GHRA_ECO7I (B7NLA1), GHRA_ECO81 (B7MTG4), GHRA_ECO8A (B7M907), GHRA_ECOBW (C4ZRX4), GHRA_ECODH (B1X9E7), GHRA_ECOHS (A7ZYY6), GHRA_ECOK1 (A1A9T1), GHRA_ECOL5 (Q0TJ41), GHRA_ECOL6 (Q8FIT1), GHRA_ECOLC (B1IV68), GHRA_ECOLI (P75913), GHRA_ECOLU (B7N3I0), GHRA_ECOSE (B6I9A9), GHRA_ECOSM (B1LIY1), GHRA_ECOUT (Q1RDC8), GHRA_ESCF3 (B7LTA2), GHRA_PHOLL (Q7N571), GHRA_SALAR (A9MH27), GHRA_SERP5 (A8GD46), GHRA_SHIB3 (B2TTN6), GHRA_SHIBS (Q31Z89), GHRA_SHIDS (Q32HN5), GHRA_SHISS (Q3Z393), GHRB_CITK8 (A8ARD9), GHRB_CROS8 (A7MKR1), GHRB_ECO24 (A7ZTA0), GHRB_ECO27 (B7ULB4), GHRB_ECO45 (B7MER0), GHRB_ECO55 (B7L6W9), GHRB_ECO57 (P58220), GHRB_ECO5E (B5YVK6), GHRB_ECO7I (B7NP49), GHRB_ECO81 (B7N1K7), GHRB_ECO8A (B7M3H6), GHRB_ECOBW (C4ZXE2), GHRB_ECODH (B1X8G8), GHRB_ECOHS (A8A609), GHRB_ECOK1 (A1AH96), GHRB_ECOL5 (Q0TBP9), GHRB_ECOL6 (Q8FCF1), GHRB_ECOLC (B1IZP1), GHRB_ECOLI (P37666), GHRB_ECOLU (B7NEK6), GHRB_ECOSE (B6I3C3), GHRB_ECOSM (B1LJB3), GHRB_ECOUT (Q1R543), GHRB_ENT38 (A4W577), GHRB_ENTAG (P58000), GHRB_ERWT9 (B2VCD1), GHRB_ESCF3 (B7LTG7), GHRB_KLEP3 (B5XMZ4), GHRB_KLEP7 (A6TFG7), GHRB_PECAS (Q6DB24), GHRB_PECCP (C6DJ88), GHRB_SALA4 (B5EX58), GHRB_SALCH (Q57IH8), GHRB_SALDC (B5FLC2), GHRB_SALEP (B5R4N3), GHRB_SALHS (B4T938), GHRB_SALNS (B4SWJ5), GHRB_SALPA (Q5PLL9), GHRB_SALPB (A9MUT4), GHRB_SALPC (C0Q1A7), GHRB_SALPK (B5BHT3), GHRB_SALSV (B4TZ41), GHRB_SALTI (Q8Z2A8), GHRB_SALTY (Q8ZLA1), GHRB_SERP5 (A8G7S7), GHRB_SHIB3 (B2U573), GHRB_SHIBS (Q31V71), GHRB_SHIDS (Q328L4), GHRB_SHIF8 (Q0SZE5), GHRB_SHIFL (Q83PR3), GHRB_SHISS (Q3YVT5), GHRB_YERE8 (A1JT62), GHRB_YERP3 (A7FPA2), GHRB_YERPA (Q1C3K4), GHRB_YERPB (B2K7F1), GHRB_YERPE (Q0W9V5), GHRB_YERPG (A9R4G6), GHRB_YERPN (Q1CD80), GHRB_YERPP (A4TGN1), GHRB_YERPS (Q663W4), GOR1_YEAST (P53839), GRHPR_HUMAN (Q9UBQ7), GRHPR_MOUSE (Q91Z53), GYAR_AERPE (Q9YAW4), GYAR_KORCO (B1L765), GYAR_PYRAB (Q9UYR1), GYAR_PYRFU (Q8U3Y2), GYAR_PYRHO (O58320), GYAR_THEGJ (C5A1V0), GYAR_THEKO (Q5JEZ2), GYAR_THELN (Q9C4M5), GYAR_THEON (B6YWH0), GYAR_THEPD (A1RYE4), HADHA_ASPOR (Q2UH56), HGDH_ACIFV (D2RJU7), HPR_BLAHS (C0CMQ8), KK1H_CURCL (A0A348AXY0), LDHA_CLODI (Q5U922), LDHD_DICDI (Q54UF7), LDHD_ECOLI (P52643), LDHD_LACDA (P26297), LDHD_LACHE (P30901), LDHD_LACPE (P26298), LDHD_LACPL (Q88VJ2), LDHD_LEUMC (P51011), LDHD_PEDAC (Q59642), LDHD_STAAC (Q5HD29), LDHD_STAAM (P63940), LDHD_STAAN (P99116), LDHD_STAAR (Q6GDS2), LDHD_STAAS (Q6G6F1), LDHD_STAAU (P72357), LDHD_STAAW (Q8NUT2), LDHD_STAEQ (Q5HLA0), LDHD_STAES (Q8CN22), LDHD_STRA3 (Q8E6A9), LDHD_STRA5 (Q8E0N5), LDHD_STRP1 (Q99ZM2), LDHD_TREPA (O83080), MORA_ASPOR (Q2U0N3), PDXB_ACIAD (Q6F943), PDXB_ALIF1 (Q5E452), PDXB_ALIFM (B5FFP0), PDXB_ALISL (B6EIW3), PDXB_AZOVD (C1DM66), PDXB_BACFN (Q5LIR8), PDXB_BACFR (Q64ZV5), PDXB_BACTN (Q8A2E4), PDXB_BLOFL (Q7VRU9), PDXB_BLOPB (Q492H2), PDXB_CELJU (B3PK14), PDXB_CITK8 (A8ADQ9), PDXB_COXBN (A9KEY5), PDXB_COXBR (A9NAQ7), PDXB_COXBU (Q83AR8), PDXB_CROS8 (A7MH63), PDXB_ECO24 (A7ZPD6), PDXB_ECO27 (B7UFX8), PDXB_ECO45 (B7MG84), PDXB_ECO55 (B7LBH4), PDXB_ECO57 (Q8XCR0), PDXB_ECO5E (B5YXW1), PDXB_ECO7I (B7NP01), PDXB_ECO81 (B7MXZ7), PDXB_ECO8A (B7M6K1), PDXB_ECOBW (C4ZVL3), PDXB_ECODH (B1X931), PDXB_ECOHS (A8A2I9), PDXB_ECOK1 (A1ADG9), PDXB_ECOL5 (Q0TFC6), PDXB_ECOL6 (Q8FFH2), PDXB_ECOLC (B1IXM2), PDXB_ECOLI (P05459), PDXB_ECOLU (B7N5T2), PDXB_ECOSE (B6I4U8), PDXB_ECOSM (B1LLS6), PDXB_ECOUT (Q1R992), PDXB_ECTM1 (A4XTK4), PDXB_EDWI9 (C5B8N0), PDXB_ENT38 (A4WCV4), PDXB_ESCF3 (B7LLF0), PDXB_HAHCH (Q2SJQ9), PDXB_KLEP3 (B5XNR7), PDXB_LEGPA (Q5X6I6), PDXB_LEGPH (Q5ZX15), PDXB_LEGPL (Q5WXZ0), PDXB_PECAS (Q6D2N5), PDXB_PECCP (C6DA76), PDXB_PHOLL (Q7N2B2), PDXB_PHOPR (Q6LNU2), PDXB_PROMH (B4EZF9), PDXB_PSE14 (Q48KQ3), PDXB_PSEA6 (Q15QG8), PDXB_PSEA8 (B7UVK4), PDXB_PSEAB (Q02JM2), PDXB_PSEAE (Q9I3W9), PDXB_PSEE4 (Q1I7B3), PDXB_PSEF5 (Q4KFD1), PDXB_PSEFS (C3K5G7), PDXB_PSEP1 (A5W6I8), PDXB_PSEP7 (A6V8H9), PDXB_PSEPF (Q3K9D1), PDXB_PSEPG (B0KGD9), PDXB_PSEPK (Q88L20), PDXB_PSEPW (B1J5D7), PDXB_PSESM (Q884R9), PDXB_PSEU2 (Q4ZVE7), PDXB_SALA4 (B5EZQ4), PDXB_SALAR (A9MJ55), PDXB_SALCH (Q57LY4), PDXB_SALDC (B5FPL4), PDXB_SALEP (B5R3Q1), PDXB_SALG2 (B5RCJ5), PDXB_SALHS (B4TBN9), PDXB_SALNS (B4SZP2), PDXB_SALPA (Q5PCV8), PDXB_SALPB (A9N474), PDXB_SALPC (C0PZZ3), PDXB_SALPK (B5BCH6), PDXB_SALSV (B4TQA6), PDXB_SALTI (P60801), PDXB_SALTY (P60802), PDXB_SERP5 (A8GH44), PDXB_SHEAM (A1S7K2), PDXB_SHEB2 (B8EEB4), PDXB_SHEB5 (A3D669), PDXB_SHEB8 (A6WQ07), PDXB_SHEB9 (A9KTV0), PDXB_SHEFN (Q084S1), PDXB_SHEHH (B0TKZ7), PDXB_SHELP (A3QFC7), PDXB_SHEON (Q8ECR2), PDXB_SHEPC (A4Y882), PDXB_SHESA (A0KV91), PDXB_SHESH (A8FTT7), PDXB_SHESM (Q0HKB6), PDXB_SHESP (Q56731), PDXB_SHESR (Q0HWL8), PDXB_SHESW (A1RIA7), PDXB_SHEVD (Q56733), PDXB_SHEWM (B1KKP1), PDXB_SHIB3 (B2TWA2), PDXB_SHIBS (Q31YD8), PDXB_SHIDS (Q32DL6), PDXB_SHIF8 (Q0T2G5), PDXB_SHIFL (Q83QR1), PDXB_SHISS (Q3YZP1), PDXB_SODGM (Q2NSH9), PDXB_STUS1 (A4VKJ1), PDXB_TERTT (C5BR49), PDXB_VIBA3 (B7VL81), PDXB_VIBCH (Q9KQ92), PDXB_VIBPA (Q87MN8), PDXB_VIBVU (Q8DB36), PDXB_VIBVY (Q7MIT6), PDXB_WIGBR (Q8D2P6), PDXB_YERE8 (A1JL55), PDXB_YERP3 (A7FGL9), PDXB_YERPA (Q1C676), PDXB_YERPB (B2K8H7), PDXB_YERPE (Q8D0U3), PDXB_YERPG (A9R7V0), PDXB_YERPN (Q1CHL8), PDXB_YERPP (A4TM66), PDXB_YERPS (Q668W7), PDXB_YERPY (B1JGI0), PTXD_STUST (O69054), SER33_YEAST (P40510), SERA1_ARATH (O49485), SERA2_ARATH (O04130), SERA3_ARATH (Q9LT69), SERA_ARCFU (O29445), SERA_BACSU (P35136), SERA_BOVIN (Q5EAD2), SERA_ECO57 (P0A9T2), SERA_ECOL6 (P0A9T1), SERA_ECOLI (P0A9T0), SERA_HAEIN (P43885), SERA_HUMAN (O43175), SERA_MACFA (Q60HD7), SERA_METJA (Q58424), SERA_METTH (O27051), SERA_MOUSE (Q61753), SERA_MYCBO (P0A545), SERA_MYCLE (O33116), SERA_MYCTO (P9WNX2), SERA_MYCTU (P9WNX3), SERA_PANTR (A5A6P1), SERA_PIG(A5GFY8), SERA_PONAB (Q5R7M2), SERA_RAT(O08651), SERA_SCHPO (P87228), SERA_SHIFL (P0A9T3), SERA_SYNY3 (P73821), SERA_YEAST (P40054), SLCC_CHRSD (Q1QWN6), VANH_ENTFA (Q47748), VANH_ENTFC (Q05709), Y1556_HAEIN (P45250), Y1879_STAES (Q8CNB8), Y1888_STAEQ (Q5HLU4), Y2355_CORGL (P0C1E8), Y752_STAHJ (Q4L8G4), YEAA_SCHPO (O14075), YGDH_SCHPO (O94574), YGT5_YEAST (P53100), YPRB2_CORML (P0C1E9)» more
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| UniProtKB/Swiss-Prot False negative sequences |
69 sequences
2KGR_GLUOX (Q5FTU6), CTBP1_CAEEL (Q20595), CTBP_ARATH (O23702), DDH_HALMT (Q2VEQ7), FDH2_ORYSJ (Q67U69), GHRA_ENT38 (A4W948), GHRA_KLEP3 (B5XXL3), GHRA_KLEP7 (A6T7B8), GHRA_SALA4 (B5F974), GHRA_SALCH (Q57QM2), GHRA_SALDC (B5FL30), GHRA_SALEP (B5QY30), GHRA_SALG2 (B5RBG3), GHRA_SALHS (B4TEQ6), GHRA_SALNS (B4T2W6), GHRA_SALPA (Q5PGZ3), GHRA_SALPB (A9N5T3), GHRA_SALPC (C0Q872), GHRA_SALPK (B5BBF3), GHRA_SALSV (B4TSP5), GHRA_SALTI (Q8Z7M6), GHRA_SALTY (Q8ZQ30), GHRA_YERE8 (A1JRR3), GHRB_SALG2 (B5RGN1), GHRB_YERPY (B1JH01), HPR_THEMA (Q9X1C1), PDXB_ACIB3 (B7GY62), PDXB_ACIB5 (B7I5Z2), PDXB_ACIBC (B2HX89), PDXB_ACIBS (B0VT23), PDXB_ACIBT (A3M810), PDXB_ACIBY (B0VDM7), PDXB_AERHH (A0KLP0), PDXB_AERS4 (A4SNU1), PDXB_ALCBS (Q0VQC3), PDXB_BAUCH (Q1LTA7), PDXB_CHRSD (Q1QXV7), PDXB_COLP3 (Q47XK1), PDXB_HYDCU (Q31IH6), PDXB_IDILO (Q5QUE2), PDXB_MARMS (A6VXM3), PDXB_MARN8 (A1U1I8), PDXB_PORGI (Q7MV70), PDXB_PSET1 (Q3IF36), PDXB_PSYA2 (Q4FV16), PDXB_PSYCK (Q1QE21), PDXB_PSYIN (A1SW94), PDXB_PSYWF (A5WHK7), PDXB_RUTMC (A1AWW7), PDXB_SACD2 (Q21LK8), PDXB_SALRD (Q2S0U3), PDXB_SHEDO (Q12P58), PDXB_TOLAT (C4LF16), PDXB_VESOH (A5CWD1), SERA_DICDI (Q54UH8), TKRA_BACSU (O32264), TKRA_DICDI (Q54DP1), Y2098_STAAN (Q7A417), Y2178_STAAB (Q2YYT9), Y2196_STAAS (Q6G716), Y2224_STAAW (Q8NV80), Y2254_STAA3 (Q2FEI9), Y2296_STAAC (Q5HDQ4), Y2305_STAAM (Q99RW8), Y2389_STAAR (Q6GEC9), Y2577_STAA8 (Q2FVW4), Y606_STAS1 (Q49ZM5), YOAD_BACSU (O34815), YP113_YEAST (Q02961)» more |
| UniProtKB/Swiss-Prot 'Partial' sequences |
1 sequence
YMP5_STRCH (P43169) |
| UniProtKB/Swiss-Prot False positive sequences |
1 sequence
VF030_IIV3 (Q196V4) |
| PDB [Detailed view] |
101 PDB
pdb_00001dxy; pdb_00001gdh; pdb_00001hku; pdb_00001hl3; pdb_00001j49; pdb_00001j4a; pdb_00001mx3; pdb_00001psd; pdb_00001sc6; pdb_00001yba; pdb_00001ygy; pdb_00002dbq; pdb_00002dbr; pdb_00002dbz; pdb_00002dld; pdb_00002fss; pdb_00002g76; pdb_00002gcg; pdb_00002go1; pdb_00002gug; pdb_00002h1s; pdb_00002hu2; pdb_00002j6i; pdb_00002nac; pdb_00002nad; pdb_00002o4c; pdb_00002ome; pdb_00002p9c; pdb_00002p9e; pdb_00002p9g; pdb_00002pa3; pdb_00002q50; pdb_00002wwr; pdb_00003dc2; pdb_00003ddn; pdb_00003ga0; pdb_00003jtm; pdb_00003n7u; pdb_00003naq; pdb_00003oet; pdb_00004e5k; pdb_00004e5m; pdb_00004e5n; pdb_00004e5p; pdb_00004ebf; pdb_00004lce; pdb_00004lcj; pdb_00004nu5; pdb_00004nu6; pdb_00004u6q; pdb_00004u6s; pdb_00005aov; pdb_00005dt9; pdb_00005n53; pdb_00005n6c; pdb_00005nzo; pdb_00005nzp; pdb_00005nzq; pdb_00005ofm; pdb_00005ofv; pdb_00005ofw; pdb_00005z1z; pdb_00006cdf; pdb_00006cdr; pdb_00006cwa; pdb_00006juj; pdb_00006juk; pdb_00006jwg; pdb_00006jx1; pdb_00006ovl; pdb_00006oxn; pdb_00006p35; pdb_00006plf; pdb_00006plg; pdb_00006rih; pdb_00006rj2; pdb_00006rj3; pdb_00006rj5; pdb_00006rj6; pdb_00006t8y; pdb_00006t8z; pdb_00006t92; pdb_00006t94; pdb_00006v89; pdb_00006v8a; pdb_00006wkw; pdb_00007cvp; pdb_00007dkm; pdb_00007ewh; pdb_00007jp2; pdb_00007kwm; pdb_00007va1; pdb_00007wn9; pdb_00008ari; pdb_00008ati; pdb_00008grv; pdb_00008pin; pdb_00008pio; pdb_00008pir; pdb_00008pis; pdb_00008q2i » more |