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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00729


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PURL: https://purl.expasy.org/prosite/signature/PS00729

Direct ScanProsite submission
General information about the entry

Entry name [info] AP_NUCLEASE_F2_1
Accession [info] PS00729
Entry type [info] PATTERN
Date [info] 01-DEC-1992 CREATED;
01-DEC-2001 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00599

Name and characterization of the entry

Description [info] AP endonucleases family 2 signature 1.
Pattern [info] 
H-[GSAD]-x-Y-[LIF]-[LIMN]-N-[LIVMFCAP]-[AGC].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 238 in 238 different sequences
Number of true positive hits 233 in 233 different sequences
Number of 'unknown' hits 0
Number of false positive hits 5 in 5 different sequences
Number of false negative sequences 44
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 97.90 %
Recall (true positives / (true positives + false negatives)) 84.12 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] zinc at position 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 233 sequences 

APN1_CAEEL  (Q10002), APN1_PLABA  (A0A509ASK2), APN1_PLAF7  (Q8IE02), 

APN1_SCHPO  (P50525), APN1_YEAST  (P22936), END4_ACHLI  (A9NFH1), 
END4_ACTP2  (A3MZ76), END4_ACTP7  (B3H0M0), END4_ACTPJ  (B0BTA9), 
END4_AERHH  (A0KK26), END4_AERS4  (A4SMZ0), END4_ALIB4  (A8EWW1), 
END4_ANOFW  (B7GH81), END4_AQUAE  (O67551), END4_AYWBP  (Q2NJF9), 
END4_BACAA  (C3P8J1), END4_BACAC  (C3LKW3), END4_BACAH  (A0RIQ8), 
END4_BACAN  (Q81LV1), END4_BACC0  (B7JN09), END4_BACC2  (B7IYD6), 
END4_BACC3  (C1ES07), END4_BACC4  (B7HCQ9), END4_BACC7  (B7HPI4), 
END4_BACCN  (A7GSY1), END4_BACCQ  (B9IY53), END4_BACCR  (Q818H3), 
END4_BACCZ  (Q634Q3), END4_BACFN  (Q5LG28), END4_BACFR  (Q64WY5), 
END4_BACHK  (Q6HDN3), END4_BACLD  (Q65HA0), END4_BACMK  (A9VHR4), 
END4_BACSU  (P54476), END4_BACTN  (Q89YT0), END4_BACVZ  (A7Z6S8), 
END4_BUCA5  (B8D8T8), END4_BUCAI  (P57237), END4_BUCAP  (P59058), 
END4_BUCAT  (B8D742), END4_BUCBP  (P59496), END4_CAMC1  (A8Z6D9), 
END4_CAMC5  (A7GW36), END4_CAMHC  (A7I010), END4_CHLAA  (A9WII8), 
END4_CHLAB  (Q5L798), END4_CHLAD  (B8G418), END4_CHLCH  (Q3AT74), 
END4_CHLCV  (Q824X6), END4_CHLL2  (B3EEJ7), END4_CHLL3  (Q3B5R5), 
END4_CHLMU  (Q9PJB8), END4_CHLP8  (B3QQA9), END4_CHLPB  (B3ELV8), 
END4_CHLPM  (A4SDE2), END4_CHLPN  (Q9Z7H3), END4_CHLSY  (B9LAM9), 
END4_CHLT2  (B0B8K0), END4_CHLTA  (Q3KL70), END4_CHLTB  (B0BA79), 
END4_CHLTE  (Q8KFL0), END4_CHLTR  (O84630), END4_CITBB  (B5EAS8), 
END4_CITK8  (A8AE66), END4_DESAH  (C0QMG1), END4_DESOH  (A8ZSE7), 
END4_DESPS  (Q6ASE4), END4_DICDI  (Q966U0), END4_ECO24  (A7ZNY3), 
END4_ECO27  (B7UFH5), END4_ECO45  (B7MF74), END4_ECO55  (B7LAI2), 
END4_ECO57  (P0A6C2), END4_ECO5E  (B5YWV0), END4_ECO7I  (B7NMX3), 
END4_ECO81  (B7MX24), END4_ECO8A  (B7M507), END4_ECOBW  (C4ZU09), 
END4_ECODH  (B1X857), END4_ECOHS  (A8A222), END4_ECOK1  (A1AD18), 
END4_ECOL5  (Q0TFT1), END4_ECOL6  (Q8FFU0), END4_ECOLC  (B1IYB0), 
END4_ECOLI  (P0A6C1), END4_ECOLU  (B7N5C2), END4_ECOSE  (B6I8L0), 
END4_ECOSM  (B1LKQ6), END4_ECOUT  (Q1R9R2), END4_EDWI9  (C5BCN2), 
END4_ENT38  (A4WCJ5), END4_ENTFA  (Q834D0), END4_ERWT9  (B2VIH1), 
END4_ESCF3  (B7LVB9), END4_EXIS2  (B1YL88), END4_GEODF  (B9M4N1), 
END4_GEOKA  (Q5KX27), END4_GEOSL  (Q74FS7), END4_GEOSM  (C6DYE3), 
END4_GEOSW  (C5D4R0), END4_GEOTN  (A4IR02), END4_GLAP5  (B8F7D1), 
END4_HAEDU  (Q7VMC4), END4_HALH5  (Q9KD33), END4_HALHL  (A1WXM0), 
END4_HALOH  (B8CW79), END4_HERA2  (A9B5N7), END4_KLEP3  (B5XP51), 
END4_KLEP7  (A6TBP4), END4_LACP7  (A9KNS9), END4_LACPL  (Q88VR2), 
END4_LISIN  (Q92BR0), END4_LISMC  (C1KV96), END4_LISMF  (Q71ZM1), 
END4_LISMO  (Q8Y756), END4_LISW6  (A0AIQ1), END4_LYSSC  (B1HTF6), 
END4_MAGMM  (A0L901), END4_MALP2  (Q8EWT2), END4_MESH2  (Q601Y6), 
END4_MESH7  (Q4A8V0), END4_MESHJ  (Q4AAX4), END4_METST  (Q2NFM3), 
END4_MYCBO  (P63536), END4_MYCBP  (A1KGF0), END4_MYCBT  (C1AL03), 
END4_MYCCT  (Q2ST57), END4_MYCGA  (Q7NBA9), END4_MYCGE  (P47477), 
END4_MYCLB  (B8ZSC5), END4_MYCLE  (P30770), END4_MYCMM  (B2HSJ8), 
END4_MYCMS  (Q6MUC7), END4_MYCPN  (P75457), END4_MYCPU  (Q98PU8), 
END4_MYCS5  (Q4A6S5), END4_MYCTA  (A5U056), END4_MYCTO  (P9WQ12), 
END4_MYCTU  (P9WQ13), END4_MYCUA  (A0PM27), END4_NAUPA  (B9L9K0), 
END4_NITSB  (A6Q1P1), END4_NITV2  (Q72CQ9), END4_NITV4  (A1VEI5), 
END4_OCEIH  (Q8EPZ2), END4_OLEA2  (Q30YP7), END4_ONYPE  (Q6YQC1), 
END4_PARD8  (A6LB99), END4_PARUW  (Q6MED0), END4_PECAS  (Q6D3L8), 
END4_PECCP  (C6DEL1), END4_PELPB  (B4SE58), END4_PETMO  (A9BJ15), 
END4_PHOLL  (Q7N364), END4_PHOPR  (Q6LUP5), END4_PHOV8  (A6L330), 
END4_PROA2  (B4S3I3), END4_PROMH  (B4ETA5), END4_SALA4  (B5EYQ5), 
END4_SALAR  (A9MK49), END4_SALCH  (Q57MD6), END4_SALDC  (B5FNK8), 
END4_SALEP  (B5R173), END4_SALG2  (B5RC42), END4_SALHS  (B4TAM6), 
END4_SALNS  (B4SY37), END4_SALPA  (Q5PE50), END4_SALPB  (A9N6I5), 
END4_SALPC  (C0Q0T7), END4_SALPK  (B5BE34), END4_SALSV  (B4TNR0), 
END4_SALTI  (Q8Z593), END4_SALTY  (Q8ZNK6), END4_SERP5  (A8GGT5), 
END4_SHIB3  (B2TVT4), END4_SHIBS  (Q31YW6), END4_SHIDS  (Q32EQ7), 
END4_SHIF8  (Q0T2W5), END4_SHIFL  (Q83QW6), END4_SHISS  (Q3Z047), 
END4_SHOC1  (Q5WHC2), END4_STAA1  (A7X2V2), END4_STAA2  (A6U229), 
END4_STAA3  (Q2FGG6), END4_STAA8  (Q2FY16), END4_STAA9  (A5IT85), 
END4_STAAB  (Q2YT22), END4_STAAC  (Q5HFK3), END4_STAAE  (A6QHA0), 
END4_STAAM  (P63537), END4_STAAN  (P63538), END4_STAAR  (Q6GGE2), 
END4_STAAS  (Q6G909), END4_STAAT  (A8Z497), END4_STAAW  (P63539), 
END4_STACT  (B9DNM8), END4_STAEQ  (Q5HNZ1), END4_STAES  (Q8CP25), 
END4_STAHJ  (Q4L6Q7), END4_STAS1  (Q49Y00), END4_STRAW  (Q82AG6), 
END4_STRCO  (Q9S2N2), END4_SULDN  (Q30PH2), END4_SULNB  (A6QCI0), 
END4_THEAB  (B7IDS7), END4_THEAC  (Q9HJS3), END4_THEM4  (A6LMU8), 
END4_THEMA  (Q9WYJ7), END4_THEP1  (A5IK54), END4_THESQ  (B1L9C6), 
END4_THEVO  (Q97A09), END4_TOLAT  (C4LD49), END4_TRIL1  (B3E325), 
END4_UREPA  (Q9PQI5), END4_UREU1  (B5ZBB4), END4_VIBC1  (A7MS84), 
END4_VIBC3  (A5F5R6), END4_VIBCH  (Q9KPK7), END4_VIBCM  (C3LQD2), 
END4_VIBPA  (Q87SC6), END4_VIBVU  (Q8DEP6), END4_VIBVY  (Q7MNR1), 
END4_WOLSU  (Q7M8B4), END4_YERE8  (A1JLX8), END4_YERP3  (A7FK62), 
END4_YERPA  (Q1C982), END4_YERPB  (B2K9J1), END4_YERPE  (Q8ZGJ1), 
END4_YERPG  (A9R4S1), END4_YERPN  (Q1CG79), END4_YERPP  (A4TNA4), 
END4_YERPS  (Q66CR5), END4_YERPY  (B1JRM5)
» more

UniProtKB/Swiss-Prot
False negative sequences		 44 sequences 

APE_ASFB7   (Q65202), APE_ASFK5   (P0C9C8), APE_ASFM2   (Q65246), 

APE_ASFP4   (P0C9C6), APE_ASFWA   (P0C9C7), END4_AKKM8  (B2UQE3), 
END4_ALKOO  (A8ML82), END4_BIFLD  (B3DS13), END4_BIFLO  (Q8G689), 
END4_BIFLS  (B7GRN1), END4_CAMFF  (A0RRG4), END4_CARHZ  (Q3ABA7), 
END4_CENSY  (A0RYW7), END4_CLOB8  (A6LQV9), END4_CLOBA  (B2V158), 
END4_CLOBB  (B2TL64), END4_CLOD6  (Q189A4), END4_CROS8  (A7MLL2), 
END4_FINM2  (B0S196), END4_HALMA  (Q5V0S8), END4_HALS3  (B0R2U6), 
END4_HALSA  (Q9HSK7), END4_HALWD  (Q18KA6), END4_HELMI  (B0TD39), 
END4_LATSS  (Q38XB2), END4_MESFL  (Q6F1D3), END4_META1  (B3PMH1), 
END4_METLZ  (A2SPZ6), END4_METMJ  (A3CT71), END4_METPE  (B8GKX5), 
END4_MIMIV  (Q5UPY4), END4_MOOTA  (Q2RJF1), END4_MYCAP  (A5IYT8), 
END4_MYCM1  (Q6KH96), END4_NATPD  (Q3IMK8), END4_NATTJ  (B2A499), 
END4_NITMS  (A9A555), END4_PEDPA  (Q03F56), END4_PERMH  (C0QRI1), 
END4_SOLUE  (Q01TU5), END4_SULSY  (B2V7A4), END4_SYMTH  (Q67S99), 
END4_THENN  (B9KBS2), END4_THET2  (Q72KH8)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

END4_THENE  (O86954), END4_YEREN  (P42691)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			5 sequences
			


			
EZH1_BOVIN  (A7E2Z2), EZH1_HUMAN  (Q92800), EZH1_MOUSE  (P70351), 

			
EZH1_PONAB  (Q5RDS6), GCP4_DROME  (Q9VKU7)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			14 PDB
			


			pdb_00001qtw; pdb_00001qum; pdb_00001xp3; pdb_00002nqh; pdb_00002nqj; pdb_00002x7v; pdb_00002x7w; pdb_00003aal; pdb_00004hno; pdb_00005zhz; pdb_00008axy; pdb_00008edd; 
			
				pdb_00008pkb; pdb_00008rly
			
			

			» more