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PROSITE entry PS00761

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PURL: https://purl.expasy.org/prosite/signature/PS00761

Direct ScanProsite submission

General information about the entry

Entry name [info]	SPASE_I_3
Accession [info]	PS00761
Entry type [info]	PATTERN
Date [info]	01-DEC-1992 CREATED; 01-APR-2006 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00418

Name and characterization of the entry

Description [info]	Signal peptidases I signature 3.
Pattern [info]	[LIVMFYW](2)-{NLPA}-{T}-G-D-[NH]-{PIEW}-x(2)-[SND]-x(2)-[SG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2026_03 which contains 575'748 sequence entries.

Total number of hits	113 in 113 different sequences
Number of true positive hits	90 in 90 different sequences
Number of 'unknown' hits	0
Number of false positive hits	23 in 23 different sequences
Number of false negative sequences	61
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	79.65 %
Recall (true positives / (true positives + false negatives))	59.60 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Version [info]	2

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	90 sequences IMP1A_ARATH (Q6NLT8), IMP2L_BOVIN (Q2KI92), IMP2L_DANRE (Q6AZD4), IMP2L_HUMAN (Q96T52), IMP2L_MOUSE (Q8BPT6), IMP2L_XENLA (Q5PQ63), IMP2_YEAST (P46972), LEP1_BACAM (P41026), LEP1_SYNY3 (P72660), LEP2_BACAM (P41025), LEP2_SYNY3 (P73157), LEPP_BACNA (P37943), LEPQ_BACNA (Q57350), LEPS_BACSU (P28628), LEPT_BACSU (P71013), LEPU_BACSU (P42959), LEPV_BACSU (O07560), LEP_AQUAE (O67088), LEP_BACCL (P41027), LEP_BACLI (P42668), LEP_BUCAI (P57347), LEP_BUCAP (Q8K9R0), LEP_BUCBP (Q89AM6), LEP_ECOLI (P00803), LEP_HAEIN (P44454), LEP_HELPJ (Q9ZLQ5), LEP_HELPY (O25300), LEP_LEPLM (Q51876), LEP_MYCLE (O33021), LEP_MYCTO (P9WKA0), LEP_MYCTU (P9WKA1), LEP_PSEAE (Q9I5G7), LEP_PSEFL (P26844), LEP_RICAH (A8GM78), LEP_RICB8 (A8GYE1), LEP_RICBR (Q1RHA1), LEP_RICCK (A8EXI2), LEP_RICCN (Q92JB1), LEP_RICFE (Q4UKA7), LEP_RICM5 (A8F0M1), LEP_RICPR (Q9ZE32), LEP_RICRS (A8GQT7), LEP_RICTY (Q8L2J7), LEP_SALTI (P0A1W3), LEP_SALTY (P0A1W2), LEP_STAAC (Q5HHB9), LEP_STAAM (P0A067), LEP_STAAN (P0A068), LEP_STAAR (Q6GIC3), LEP_STAAS (Q6GAW1), LEP_STAAU (P0A070), LEP_STAAW (P0A069), PLSP1_ARATH (Q8H0W1), SC11A_BOVIN (P67810), SC11A_CANLF (P67811), SC11A_HUMAN (P67812), SC11A_MOUSE (Q9R0P6), SC11A_PONAB (Q5R9C7), SC11A_RAT (P42667), SC11B_HUMAN (P0C7V7), SC11C_CANLF (P13679), SC11C_HUMAN (Q9BY50), SC11C_MOUSE (Q9D8V7), SC11C_PONAB (Q5RC30), SC11C_RAT (Q9WTR7), SEC11_CANAL (Q5A869), SEC11_CANAW (C4YNJ0), SEC11_CANDC (B9WKT4), SEC11_CANTT (C5M4J6), SEC11_CLAL4 (C4Y3D4), SEC11_DEBHA (Q6BP15), SEC11_KOMPG (C4QXP7), SEC11_LODEL (A5DS09), SEC11_PICGU (A5DIZ8), SEC11_PICST (A3LXS1), SEC11_PLAF7 (Q8IE14), SEC11_SCHCM (D8Q7Q5), SEC11_YARLI (Q6CAG9), SEC11_YEAS1 (B3LTI7), SEC11_YEAS2 (C7GLT4), SEC11_YEAS7 (A6ZVU2), SEC11_YEAS8 (C8ZAS4), SEC11_YEASA (E7KDY6), SEC11_YEASB (E7Q587), SEC11_YEASL (E7KQ01), SEC11_YEAST (P15367), SEC11_YEASV (E7LVX4), SEC11_YEASZ (E7QG89), TPP1_ARATH (O04348), TPP2_ARATH (Q9M9Z2) » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	61 sequences IMP1L_HUMAN (Q96LU5), IMP1L_MOUSE (Q9CQU8), IMP1L_XENTR (Q28I39), IMP1_YEAST (P28627), IMP2L_SCHPO (Q9UST2), LEPH_STAAC (Q5HHC0), LEPH_STAAM (P0A063), LEPH_STAAN (P0A064), LEPH_STAAR (Q6GIC4), LEPH_STAAS (Q6GAW2), LEPH_STAAU (P0A066), LEPH_STAAW (P0A065), LEP_STRPN (O07344), LEP_STRR6 (P59662), SEC11_AJEC8 (F0UDD2), SEC11_AJECG (C0NKT8), SEC11_AJECH (C6HB29), SEC11_AJEDR (C5G8L5), SEC11_ARTBC (D4ALL0), SEC11_ARTGP (E4V4X0), SEC11_ARTOC (C5FQ45), SEC11_ASPCL (A1CL29), SEC11_ASPF1 (A1D6D8), SEC11_ASPFC (B0XWT3), SEC11_ASPFU (Q4WYF4), SEC11_ASPOR (Q2UBW3), SEC11_ASPTN (Q0CQC5), SEC11_BLAGS (C5JJG5), SEC11_CHAGB (Q2H1P3), SEC11_COCP7 (C5PA33), SEC11_COCPS (E9CXH2), SEC11_COLGM (E3QXY4), SEC11_EMENI (Q5B8K4), SEC11_EREGS (Q759W4), SEC11_FUSV7 (C7ZHK5), SEC11_GROCL (F0XJH4), SEC11_HISMI (A6QX24), SEC11_KLULA (Q6CMR5), SEC11_LACBS (B0D4L0), SEC11_LACTC (C5DDH1), SEC11_LEPMJ (E5A8D2), SEC11_METAQ (E9E796), SEC11_METRA (E9F8V9), SEC11_NEUCR (Q7RY44), SEC11_OGAPD (E7R7C4), SEC11_PARBA (C1GU90), SEC11_PARBD (C1FYD2), SEC11_PARBP (C0S3S0), SEC11_PENRW (B6HC89), SEC11_PODAN (B2B3T2), SEC11_PYRO7 (A4RGA1), SEC11_PYRTR (B2WEL2), SEC11_PYRTT (E3RR70), SEC11_SCLS1 (A7E716), SEC11_TALMQ (B6Q5G0), SEC11_TALSN (B8M5K5), SEC11_TRIVH (D4D5I1), SEC11_TUBMM (D5GNC3), SEC11_UNCRE (C4JYM4), SEC11_VERA1 (C9S8G0), SEC11_ZYGRC (C5E3W1) » more
UniProtKB/Swiss-Prot False positive sequences	23 sequences ACSA_PASMU (Q9CMW1), ADPRL_MIMIV (Q5UQP4), C508D_DICDI (Q1ZXA4), CBIK_SALTY (Q05592), CCDC9_MOUSE (Q8VC31), CT54_CONVE (Q9BPF7), DGOK_ECOLI (P31459), GLNA1_DICDI (Q86B00), HAUS3_DANRE (Q08CD9), HLDE_DICNV (A5EWS4), MYO7B_MOUSE (Q99MZ6), NACA_DICDI (Q54U07), OADC_PARXL (Q13Q00), PILR3_ARATH (O65679), PUM8_ARATH (Q9LM20), PURT_ACIAD (Q6FAM6), RECA_IDILO (Q5QUB8), SPT_CAUVN (A0A0H3C7E9), SYR_OCEIH (Q8EM45), TCPH_PLAF7 (O77323), THAL_ARATH (Q8L3P4), UBP15_ORYSJ (Q0E2F9), Y309_MYCGE (P47551) » more
PDB [Detailed view]	13 PDB pdb_00001b12; pdb_00001kn9; pdb_00001t7d; pdb_00003iiq; pdb_00003s04; pdb_00004wvg; pdb_00004wvh; pdb_00004wvi; pdb_00004wvj; pdb_00006b88; pdb_00007p2p; pdb_00007p2q; pdb_00009nlo » more