The following enzymes have been shown  to be functionally as well as
α-isopropylmalate synthase (EC 220.127.116.11) which catalyzes the first step
in the biosynthesis of leucine, the condensation of acetyl-CoA and α-
ketoisovalerate to form 2-isopropylmalate synthase.
Homocitrate synthase (EC 18.104.22.168) (gene nifV) which is involved in the
biosynthesis of the iron-molybdenum cofactor of nitrogenase and catalyzes
the condensation of acetyl-CoA and α-ketoglutarate into homocitrate.
Soybean late nodulin 56.
Methanococcus jannaschii hypothetical proteins MJ0503, MJ1195 and MJ1392.
We have selected two conserved regions as signature patterns for these
enzymes. The first region is located in the N-terminal section while the
second region is located in the central section and contains two conserved
histidine residues which could be implicated in the catalytic mechanism.
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