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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00892


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PURL: https://purl.expasy.org/prosite/signature/PS00892

Direct ScanProsite submission
General information about the entry

Entry name [info] HIT_1
Accession [info] PS00892
Entry type [info] PATTERN
Date [info] 01-OCT-1993 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00694

Name and characterization of the entry

Description [info] HIT domain signature.
Pattern [info] 
[NQAR]-x(4)-[GSAVY]-x-[QFLPA]-x-[LIVMY]-x-[HWYRQ]-[LIVMFYST]-H-[LIVMFT]-
H-[LIVMF]-[LIVMFPT]-[PSGAWN].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 87 in 87 different sequences
Number of true positive hits 87 in 87 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 12
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 87.88 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 87 sequences 

APH1_SCHPO  (P49776), APTX_BOVIN  (Q7YRZ2), APTX_CANLF  (P61797), 

APTX_CHICK  (P61798), APTX_CIOIN  (P61802), APTX_DANRE  (P61799), 
APTX_DROME  (Q8MSG8), APTX_HUMAN  (Q7Z2E3), APTX_MACFA  (Q9BGQ0), 
APTX_MOUSE  (Q7TQC5), APTX_PIG(Q7YRZ1), APTX_RAT(Q8K4H4), 
APTX_TAKRU  (P61800), APTX_XENLA  (Q7T287), APTX_XENTR  (P61801), 
BH140_ARATH (Q9M041), DCPS_BOVIN  (Q8MJJ7), DCPS_HUMAN  (Q96C86), 
DCPS_MOUSE  (Q9DAR7), DCPS_PIG(Q8MIZ3), DCPS_RAT(Q8K4F7), 
DCPS_YEAST  (Q06151), DCS2_YEAST  (Q12123), FHIT_ARATH  (F4KEV7), 
FHIT_BOVIN  (Q1KZG4), FHIT_DICDI  (Q86KK2), FHIT_HUMAN  (P49789), 
FHIT_MOUSE  (O89106), FHIT_RAT(Q9JIX3), HINT1_ARATH (Q8GUN2), 
HINT1_BOVIN (P62958), HINT1_HUMAN (P49773), HINT1_MOUSE (P70349), 
HINT1_PONAB (Q5RF69), HINT1_RABIT (P80912), HINT1_RAT   (P62959), 
HINT2_BOVIN (Q8SQ21), HINT2_HUMAN (Q9BX68), HINT2_MOUSE (Q9D0S9), 
HINT3_ARATH (F4K1R2), HINT_CAEEL  (P53795), HINT_ECO57  (P0ACE8), 
HINT_ECOLI  (P0ACE7), HINT_HAEIN  (P44956), HINT_SHIFL  (P0ACE9), 
HITA_NEIGO  (O07817), HIT_BACSU   (O07513), HIT_ENTH1   (C4LYI2), 
HNT1_CANAL  (Q59WG0), HNT1_SCHPO  (O94586), HNT1_YEAST  (Q04344), 
HNT2_YEAS1  (B3LFZ1), HNT2_YEAS2  (C7GQV5), HNT2_YEAS6  (B5VGI4), 
HNT2_YEAS7  (A6ZYQ3), HNT2_YEAS8  (C8Z5L6), HNT2_YEAST  (P49775), 
NFT1_CAEEL  (O76463), NFT1_DROME  (O76464), PKIA_DICDI  (Q23921), 
Y1390_SYNE7 (P32084), Y664_CHLMU  (Q9PK09), Y866_METJA  (Q58276), 
YHI1_MYCBO  (P0A5B6), YHI1_MYCLE  (P49774), YHI1_MYCTO  (P9WML2), 
YHI1_MYCTU  (P9WML3), YHI2_MYCTO  (P9WML0), YHI2_MYCTU  (P9WML1), 
YHIT_AQUAE  (O66536), YHIT_AZOBR  (P26724), YHIT_BORBU  (P94252), 
YHIT_BUCAI  (P57438), YHIT_BUCAP  (Q8K9I9), YHIT_BUCBP  (Q89AG5), 
YHIT_CHLPN  (Q9Z863), YHIT_CHLTR  (O84390), YHIT_HELPJ  (P64383), 
YHIT_HELPY  (P64382), YHIT_MESHY  (P32083), YHIT_MYCGE  (P47378), 
YHIT_MYCPN  (P75504), YHIT_RICPR  (Q9ZDL1), YHIT_SACS2  (P95937), 
YHIT_SYNY3  (P73481), ZB14_BRAJU  (P42855), ZB14_MAIZE  (P42856)
» more

UniProtKB/Swiss-Prot
False negative sequences		 12 sequences 

AP4A_MYCTO  (P9WMK8), AP4A_MYCTU  (P9WMK9), APTX_YEAST  (Q08702), 

HINT3_BOVIN (Q2YDJ4), HINT3_DANRE (Q5PNN8), HINT3_HUMAN (Q9NQE9), 
HINT3_MOUSE (Q9CPS6), HINT3_PONAB (Q5R9L4), HINT3_RAT   (Q8K3P7), 
HINT3_XENTR (Q28BZ2), HINT4_ARATH (Q84VV6), Y2839_DICDI (Q558W0)
» more

PDB
[Detailed view]		 96 PDB

pdb_00001av5; pdb_00001ems; pdb_00001fhi; pdb_00001fit; pdb_00001kpa; pdb_00001kpb; pdb_00001kpc; pdb_00001kpe; pdb_00001kpf; pdb_00001rzy; pdb_00001vlr; pdb_00001xml; pdb_00001xmm; pdb_00001y23; pdb_00002fit; pdb_00003bl7; pdb_00003bl9; pdb_00003bla; pdb_00003fit; pdb_00003n1s; pdb_00003o1c; pdb_00003o1x; pdb_00003o1z; pdb_00003oj7; pdb_00003omf; pdb_00003oxk; pdb_00003qgz; pdb_00003rhn; pdb_00003tw2; pdb_00004eqe; pdb_00004eqg; pdb_00004eqh; pdb_00004fit; pdb_00004inc; pdb_00004ini; pdb_00004ndf; pdb_00004ndg; pdb_00004ndh; pdb_00004ndi; pdb_00004qde; pdb_00004qdv; pdb_00004qeb; pdb_00004rhn; pdb_00004zgl; pdb_00004zkl; pdb_00004zkv; pdb_00005ed3; pdb_00005emt; pdb_00005fit; pdb_00005i2e; pdb_00005i2f; pdb_00005ipd; pdb_00005ipe; pdb_00005klz; pdb_00005km0; pdb_00005km1; pdb_00005km2; pdb_00005km3; pdb_00005km4; pdb_00005km5; pdb_00005km8; pdb_00005km9; pdb_00005kmc; pdb_00005o8i; pdb_00005osy; pdb_00005rhn; pdb_00005waa; pdb_00006b42; pdb_00006cvo; pdb_00006cvp; pdb_00006cvq; pdb_00006cvr; pdb_00006cvs; pdb_00006fit; pdb_00006g9z; pdb_00006iq1; pdb_00006j53; pdb_00006j58; pdb_00006n3v; pdb_00006n3w; pdb_00006n3x; pdb_00006n3y; pdb_00006rhn; pdb_00006yi0; pdb_00006ypr; pdb_00006ypx; pdb_00006yqd; pdb_00006yqm; pdb_00006yvp; pdb_00007q2u; pdb_00008p8p; pdb_00008pa6; pdb_00008pa9; pdb_00008paf; pdb_00008pai; pdb_00008pwk
» more