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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00915


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PURL: https://purl.expasy.org/prosite/signature/PS00915

Direct ScanProsite submission
General information about the entry

Entry name [info] PI3_4_KINASE_1
Accession [info] PS00915
Entry type [info] PATTERN
Date [info] 01-OCT-1993 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00710

Name and characterization of the entry

Description [info] Phosphatidylinositol 3- and 4-kinases signature 1.
Pattern [info]
[LIVMFAC]-K-x(1,3)-[DEA]-[DE]-[LIVMCP]-R-Q-[DE]-x(4)-Q.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 103 in 103 different sequences
Number of true positive hits 103 in 103 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 33
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 75.74 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
103 sequences

AGE1_CAEBR  (P0C5E7), AGE1_CAEEL  (Q94125), ATM_ARATH   (Q9M3G7), 
ATM_ASPFU   (Q4WVM7), ATM_ASPOR   (Q2U639), ATM_CANGA   (Q6FRZ9), 
ATM_DEBHA   (Q6BV76), ATM_DROME   (Q5EAK6), ATM_EMENI   (Q5BHE2), 
ATM_EREGS   (Q751J3), ATM_GIBZE   (Q4IB89), ATM_HUMAN   (Q13315), 
ATM_KLULA   (Q6CP76), ATM_MOUSE   (Q62388), ATM_NEUCR   (Q7RZT9), 
ATM_PIG (Q6PQD5), ATM_SCHPO   (O74630), ATM_YARLI   (Q6CAD2), 
ATM_YEAST   (P38110), ATR_CANGA   (Q6FX42), ATR_EREGS   (Q75DB8), 
ATR_KLULA   (Q6CT34), ATR_YEAST   (P38111), MTOR_HUMAN  (P42345), 
MTOR_MOUSE  (Q9JLN9), MTOR_RAT(P42346), P3C2A_HUMAN (O00443), 
P3C2A_MOUSE (Q61194), P3C2A_PONAB (Q5RAY1), P3C2B_HUMAN (O00750), 
P3C2G_HUMAN (O75747), P3C2G_MOUSE (O70167), P3C2G_RAT   (O70173), 
P4KA1_ARATH (Q9SXA1), P4KA2_ARATH (Q9C680), P4KB1_ARATH (Q9FMJ0), 
P4KB2_ARATH (Q0WPX9), PI3K1_DICDI (P54673), PI3K1_SOYBN (P42347), 
PI3K2_DICDI (P54674), PI3K2_SOYBN (P42348), PI3K3_DICDI (P54675), 
PI3K4_DICDI (P54676), PI3K_ARATH  (P42339), PI4KA_BOVIN (O02811), 
PI4KA_HUMAN (P42356), PI4KA_MOUSE (E9Q3L2), PI4KA_RAT   (O08662), 
PI4KB_BOVIN (O02810), PI4KB_CALJA (B0KWC1), PI4KB_DANRE (Q49GP3), 
PI4KB_HUMAN (Q9UBF8), PI4KB_MOUSE (Q8BKC8), PI4KB_OTOGA (B4UT09), 
PI4KB_PAPAN (A9X1A0), PI4KB_PLEMO (B1MTG7), PI4KB_RAT   (O08561), 
PI4KB_RHIFE (B2KI64), PI4KB_SORAR (B3EX61), PI4KB_XENLA (Q6GN16), 
PI4KB_XENTR (A4IID4), PI4K_DICDI  (P54677), PIK1_SCHPO  (Q10366), 
PIK1_YEAST  (P39104), PK3C3_CAEEL (Q9TXI7), PK3C3_HUMAN (Q8NEB9), 
PK3C3_MOUSE (Q6PF93), PK3C3_PIG   (Q5D891), PK3C3_RAT   (O88763), 
PK3C3_XENLA (Q6AZN6), PK3CA_BOVIN (P32871), PK3CA_HUMAN (P42336), 
PK3CA_MOUSE (P42337), PK3CA_RAT   (A0A0G2K344), PK3CB_HUMAN (P42338), 
PK3CB_MOUSE (Q8BTI9), PK3CB_RAT   (Q9Z1L0), PK3CD_HUMAN (O00329), 
PK3CD_MOUSE (O35904), PK3CG_HUMAN (P48736), PK3CG_MOUSE (Q9JHG7), 
PK3CG_PIG   (O02697), PRKDC_CANLF (Q8WN22), PRKDC_CHICK (Q8QGX4), 
PRKDC_HUMAN (P78527), PRKDC_MOUSE (P97313), PRKDC_XENLA (Q9DEI1), 
STT4_ENCCU  (Q8SQY7), STT4_SCHPO  (Q9USR3), STT4_YEAST  (P37297), 
TOR1_SCHPO  (O14356), TOR1_YEAST  (P35169), TOR2_SCHPO  (Q9Y7K2), 
TOR2_YEAST  (P32600), TOR_ARATH   (Q9FR53), TOR_CAEEL   (Q95Q95), 
TOR_DICDI   (Q86C65), TOR_DROME   (Q9VK45), TOR_ORYSJ   (Q0DJS1), 
VPS34_CANAL (A0A1D8PDV7), VPS34_CANAX (Q92213), VPS34_SCHPO (P50520), 
VPS34_YEAST (P22543)
» more

UniProtKB/Swiss-Prot
False negative sequences
33 sequences

LSB6_SCHPO  (Q9UT42), LSB6_YEAST  (P42951), P4K2A_DANRE (Q6PE18), 
P4K2A_HUMAN (Q9BTU6), P4K2A_MOUSE (Q2TBE6), P4K2A_RAT   (Q99M64), 
P4K2A_XENLA (Q08B31), P4K2A_XENTR (Q505I0), P4K2B_CHICK (Q5ZIK0), 
P4K2B_DANRE (Q49GP5), P4K2B_HUMAN (Q8TCG2), P4K2B_MOUSE (Q8CBQ5), 
P4K2B_RAT   (Q5XIL2), P4K2B_XENLA (Q6DCQ8), P4K2B_XENTR (Q28G26), 
P4KG1_ARATH (O22199), P4KG2_ARATH (Q9SGW8), P4KG3_ARATH (Q9FNF8), 
P4KG4_ARATH (Q9ZPY9), P4KG4_ORYSJ (Q6K881), P4KG5_ARATH (Q9C671), 
P4KG6_ARATH (Q8W4R8), P4KG7_ARATH (Q9SI52), P4KG8_ARATH (Q0WMZ6), 
PI4P2_HUMAN (A4QPH2), PIK1A_CANAL (Q9UW24), PIK1_CANAL  (Q9UW20), 
PIKI1_CAEEL (G5EDY0), TRA1_SCHPO  (Q9HFE8), TRA2_SCHPO  (Q10064), 
VPS34_CANGA (Q6FSR7), VPS34_ENCCU (Q8SR56), YL615_MIMIV (Q5UR69)
» more

PDB
[Detailed view]
437 PDB

pdb_00001e7u; pdb_00001e7v; pdb_00001e8w; pdb_00001e8x; pdb_00001e8y; pdb_00001e8z; pdb_00001e90; pdb_00001he8; pdb_00002a4z; pdb_00002a5u; pdb_00002chw; pdb_00002chx; pdb_00002chz; pdb_00002rd0; pdb_00002v4l; pdb_00002wxf; pdb_00002wxg; pdb_00002wxh; pdb_00002wxi; pdb_00002wxj; pdb_00002wxk; pdb_00002wxl; pdb_00002wxm; pdb_00002wxn; pdb_00002wxo; pdb_00002wxp; pdb_00002wxq; pdb_00002wxr; pdb_00002x38; pdb_00002y3a; pdb_00003apc; pdb_00003apd; pdb_00003apf; pdb_00003csf; pdb_00003cst; pdb_00003dbs; pdb_00003dpd; pdb_00003ene; pdb_00003hhm; pdb_00003hiz; pdb_00003ibe; pdb_00003ihy; pdb_00003jbz; pdb_00003l08; pdb_00003l13; pdb_00003l16; pdb_00003l17; pdb_00003l54; pdb_00003lj3; pdb_00003ls8; pdb_00003mjw; pdb_00003ml8; pdb_00003ml9; pdb_00003nzs; pdb_00003nzu; pdb_00003oaw; pdb_00003p2b; pdb_00003pre; pdb_00003prz; pdb_00003ps6; pdb_00003qaq; pdb_00003qar; pdb_00003qjz; pdb_00003qk0; pdb_00003r7q; pdb_00003r7r; pdb_00003s2a; pdb_00003sd5; pdb_00003t8m; pdb_00003tjp; pdb_00003tl5; pdb_00003zim; pdb_00003zvv; pdb_00003zw3; pdb_00004a55; pdb_00004ajw; pdb_00004anu; pdb_00004anv; pdb_00004anw; pdb_00004anx; pdb_00004aof; pdb_00004bfr; pdb_00004d0l; pdb_00004d0m; pdb_00004dk5; pdb_00004ezj; pdb_00004ezk; pdb_00004ezl; pdb_00004f1s; pdb_00004fa6; pdb_00004fad; pdb_00004fhj; pdb_00004fhk; pdb_00004fjy; pdb_00004fjz; pdb_00004flh; pdb_00004ful; pdb_00004g11; pdb_00004gb9; pdb_00004hle; pdb_00004hvb; pdb_00004j6i; pdb_00004jps; pdb_00004jsn; pdb_00004jsp; pdb_00004jsv; pdb_00004jsx; pdb_00004jt5; pdb_00004jt6; pdb_00004kz0; pdb_00004kzc; pdb_00004l1b; pdb_00004l23; pdb_00004l2y; pdb_00004ovu; pdb_00004ovv; pdb_00004oys; pdb_00004ph4; pdb_00004ps3; pdb_00004ps7; pdb_00004ps8; pdb_00004tuu; pdb_00004tv3; pdb_00004urk; pdb_00004uwf; pdb_00004uwg; pdb_00004uwh; pdb_00004uwk; pdb_00004uwl; pdb_00004v0i; pdb_00004wae; pdb_00004waf; pdb_00004wag; pdb_00004wwn; pdb_00004wwo; pdb_00004wwp; pdb_00004xe0; pdb_00004xx5; pdb_00004xz4; pdb_00004ykn; pdb_00004zop; pdb_00005ae8; pdb_00005ae9; pdb_00005anl; pdb_00005c46; pdb_00005c4g; pdb_00005dfz; pdb_00005dxh; pdb_00005dxt; pdb_00005dxu; pdb_00005eds; pdb_00005enn; pdb_00005euq; pdb_00005fbl; pdb_00005fbq; pdb_00005fbr; pdb_00005fbv; pdb_00005fbw; pdb_00005fi4; pdb_00005flc; pdb_00005g2n; pdb_00005g55; pdb_00005h64; pdb_00005i4u; pdb_00005i6u; pdb_00005is5; pdb_00005itd; pdb_00005jha; pdb_00005jhb; pdb_00005kae; pdb_00005kc2; pdb_00005l72; pdb_00005luq; pdb_00005m6u; pdb_00005ncy; pdb_00005ncz; pdb_00005ngb; pdb_00005np0; pdb_00005np1; pdb_00005o83; pdb_00005oq4; pdb_00005sw8; pdb_00005swg; pdb_00005swo; pdb_00005swp; pdb_00005swr; pdb_00005swt; pdb_00005sx8; pdb_00005sx9; pdb_00005sxa; pdb_00005sxb; pdb_00005sxc; pdb_00005sxd; pdb_00005sxe; pdb_00005sxf; pdb_00005sxi; pdb_00005sxj; pdb_00005sxk; pdb_00005t23; pdb_00005t27; pdb_00005t28; pdb_00005t2b; pdb_00005t2d; pdb_00005t2g; pdb_00005t2i; pdb_00005t2l; pdb_00005t2m; pdb_00005t7f; pdb_00005t8f; pdb_00005t8i; pdb_00005ubr; pdb_00005ubt; pdb_00005uk8; pdb_00005ukj; pdb_00005ul1; pdb_00005vlr; pdb_00005w1r; pdb_00005wbu; pdb_00005wby; pdb_00005x6o; pdb_00005xgh; pdb_00005xgi; pdb_00005xgj; pdb_00005y3r; pdb_00005zcs; pdb_00006aud; pdb_00006bcu; pdb_00006bcx; pdb_00006bq1; pdb_00006c1s; pdb_00006dgt; pdb_00006emk; pdb_00006eyz; pdb_00006ez6; pdb_00006fh5; pdb_00006g6w; pdb_00006gl3; pdb_00006gq7; pdb_00006gvf; pdb_00006gvg; pdb_00006gvh; pdb_00006gvi; pdb_00006gy0; pdb_00006hi9; pdb_00006i3u; pdb_00006jxa; pdb_00006jxc; pdb_00006k9k; pdb_00006k9l; pdb_00006mul; pdb_00006mum; pdb_00006nct; pdb_00006oac; pdb_00006oco; pdb_00006ocu; pdb_00006pyr; pdb_00006pys; pdb_00006pyu; pdb_00006s8f; pdb_00006sb0; pdb_00006sb2; pdb_00006t3b; pdb_00006t3c; pdb_00006xrl; pdb_00006xrm; pdb_00006xrn; pdb_00006ykg; pdb_00006z2w; pdb_00006z2x; pdb_00006z3a; pdb_00006zfp; pdb_00006zh2; pdb_00006zh4; pdb_00006zh6; pdb_00006zh8; pdb_00006zha; pdb_00006zhe; pdb_00006zwm; pdb_00006zwo; pdb_00007bi2; pdb_00007bi4; pdb_00007bi6; pdb_00007bi9; pdb_00007bl1; pdb_00007jis; pdb_00007jiu; pdb_00007jwe; pdb_00007jwz; pdb_00007jx0; pdb_00007k0y; pdb_00007k10; pdb_00007k11; pdb_00007k19; pdb_00007k1b; pdb_00007k1j; pdb_00007k1k; pdb_00007k1n; pdb_00007k6m; pdb_00007k6n; pdb_00007k6o; pdb_00007k71; pdb_00007kke; pdb_00007lm2; pdb_00007lq1; pdb_00007lt3; pdb_00007mez; pdb_00007mlk; pdb_00007myn; pdb_00007myo; pdb_00007nfc; pdb_00007nfe; pdb_00007ni4; pdb_00007ni5; pdb_00007ni6; pdb_00007otm; pdb_00007otp; pdb_00007otv; pdb_00007otw; pdb_00007oty; pdb_00007owg; pdb_00007pe7; pdb_00007pe8; pdb_00007pe9; pdb_00007pea; pdb_00007peb; pdb_00007pec; pdb_00007pg5; pdb_00007pg6; pdb_00007pqh; pdb_00007r9v; pdb_00007r9y; pdb_00007rsj; pdb_00007rsp; pdb_00007rsv; pdb_00007sgl; pdb_00007sic; pdb_00007sid; pdb_00007su3; pdb_00007sud; pdb_00007tyr; pdb_00007tz7; pdb_00007tzo; pdb_00007uxc; pdb_00007uxh; pdb_00007wzr; pdb_00007wzw; pdb_00007z61; pdb_00007z74; pdb_00007z75; pdb_00007z87; pdb_00007z88; pdb_00008a9i; pdb_00008aj8; pdb_00008am0; pdb_00008bcy; pdb_00008bfu; pdb_00008bh3; pdb_00008bhv; pdb_00008bhy; pdb_00008bot; pdb_00008dcp; pdb_00008dcx; pdb_00008dd4; pdb_00008dd8; pdb_00008dp0; pdb_00008era; pdb_00008exl; pdb_00008exo; pdb_00008exu; pdb_00008exv; pdb_00008ez9; pdb_00008eza; pdb_00008ezb; pdb_00008gua; pdb_00008gub; pdb_00008gud; pdb_00008ilr; pdb_00008ils; pdb_00008ilv; pdb_00008ow2; pdb_00008oxm; pdb_00008oxo; pdb_00008oxp; pdb_00008oxq; pdb_00008q6f; pdb_00008q6g; pdb_00008q6h; pdb_00008rch; pdb_00008rck; pdb_00008rcn; pdb_00008rd4; pdb_00008rxr; pdb_00008s3r; pdb_00008sbc; pdb_00008sbj; pdb_00008sc8; pdb_00008so9; pdb_00008soa; pdb_00008sob; pdb_00008soc; pdb_00008sod; pdb_00008soe; pdb_00008sor; pdb_00008tdu; pdb_00008tgd; pdb_00008ts7; pdb_00008ts8; pdb_00008ts9; pdb_00008tsa; pdb_00008tsb; pdb_00008tsc; pdb_00008tsd; pdb_00008tu6; pdb_00008twy; pdb_00008v8h; pdb_00008v8i; pdb_00008v8j; pdb_00008v8u; pdb_00008v8v; pdb_00008vof; pdb_00008w9a; pdb_00008w9b; pdb_00009b4s; pdb_00009b4t; pdb_00009b9g; pdb_00009bax; pdb_00009c15; pdb_00009c82; pdb_00009e4v; pdb_00009f44; pdb_00009f45; pdb_00009gcf; pdb_00009gdi; pdb_00009gg9; pdb_00009mhf; pdb_00009mhg; pdb_00009mhh
» more