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PROSITE documentation PDOC00767 [for PROSITE entry PS01001] |
Succinate dehydrogenase (SDH) is a membrane-bound complex of two main components: a membrane-extrinsic component composed of an FAD-binding flavoprotein and an iron-sulfur protein, and a hydrophobic component composed of a cytochrome B and a membrane anchor protein. The cytochrome b component is a mono heme transmembrane protein [1,2,3] belonging to a family that groups:
These cytochromes are proteins of about 130 residues that comprise three transmembrane regions. There are two conserved histidines which may be involved in binding the heme group. We developed two signature patterns that include these histidine residues.
Note:The di-heme cytochrome b-558 from Bacillus subtilis SDH complex is not a member of this family.
Last update:May 2004 / Text revised.
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PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Yu L. Wei Y.-Y. Usui S. Yu C.-A. |
Title | Cytochrome b560 (QPs1) of mitochondrial succinate-ubiquinone reductase. Immunochemistry, cloning, and nucleotide sequencing. | |
Source | J. Biol. Chem. 267:24508-24515(1992). | |
PubMed ID | 1447196 |
2 | Authors | Abraham P.R. Mulder A. van 't Riet J. Raue H.A. |
Title | Characterization of the Saccharomyces cerevisiae nuclear gene CYB3 encoding a cytochrome b polypeptide of respiratory complex II. | |
Source | Mol. Gen. Genet. 242:708-716(1994). | |
PubMed ID | 8152421 |
3 | Authors | Leblanc C. Boyen C. Richard O. Bonnard G. Grienenberger J.M. Kloareg B. |
Title | Complete sequence of the mitochondrial DNA of the rhodophyte Chondrus crispus (Gigartinales). Gene content and genome organization. | |
Source | J. Mol. Biol. 250:484-495(1995). | |
PubMed ID | 7616569 |