PROSITE documentation PDOC00779 [for PROSITE entry PS01016]
Glycoprotease family signature


Glycoprotease (GCP) (EC [1], or o-syaloglycoprotein endopeptidase, is a metalloprotease secreted by Pasteurella haemolytica which specifically cleaves O-sialoglycoproteins such as glycophorin A. The sequence of GCP is highly similar to uncharacterized orthologs in most complete genomes of bacteria and archaebacteria as well as in yeast (QRI7 and YKR038c).

One of the conserved regions contains two conserved histidines. It is possible that this region is involved in coordinating a metal ion such as zinc.


These proteins belong to family M22 in the classification of peptidases [2,E1].

Expert(s) to contact by email:

Lo R.Y.C.

Last update:

April 2006 / Pattern revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

GLYCOPROTEASE, PS01016; Glycoprotease family signature  (PATTERN)


1AuthorsAbdullah K.M. Lo R.Y.C. Mellors A.
TitleCloning, nucleotide sequence, and expression of the Pasteurella haemolytica A1 glycoprotease gene.
SourceJ. Bacteriol. 173:5597-5603(1991).
PubMed ID1885539

2AuthorsRawlings N.D. Barrett A.J.
TitleEvolutionary families of metallopeptidases.
SourceMethods Enzymol. 248:183-228(1995).
PubMed ID7674922


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