We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS01046

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PURL: https://purl.expasy.org/prosite/signature/PS01046

Direct ScanProsite submission

General information about the entry

Entry name [info]	LON_SER
Accession [info]	PS01046
Entry type [info]	PATTERN
Date [info]	01-NOV-1995 CREATED; 01-NOV-1995 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00803
Associated ProRule [info]	PRU10087

Name and characterization of the entry

Description [info]	ATP-dependent serine proteases, lon family, serine active site.
Pattern [info]	D-G-[PD]-S-A-[GS]-[LIVMCA]-[TA]-[LIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	167 in 167 different sequences
Number of true positive hits	167 in 167 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	34
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	83.08 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info]	1
Site [info]	active_site at position 4
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

167 sequences

LON1_BACSU  (P37945), LON1_BDEBA  (Q6ML73), LON1_BORBU  (Q59185),

LON1_DESPS  (Q6AS16), LON1_HERA2  (A9B5N1), LON1_HYDCU  (Q31GE9), 
LON1_MYXXA  (P36773), LON1_SORC5  (A9ETZ9), LON1_SYNC1  (Q3A701), 
LON1_SYNFM  (A0LEE9), LON1_THET2  (Q72KS4), LON2_BACSU  (P42425), 
LON2_BDEBA  (Q6MGP8), LON2_BORBU  (O51558), LON2_DESPS  (Q6AK61), 
LON2_HERA2  (A9B3R2), LON2_HYDCU  (Q31FD3), LON2_MYXXA  (P36774), 
LON2_SORC5  (A9GBF1), LON2_SYNC1  (Q3A334), LON3_SORC5  (A9GIS9), 
LON4_SORC5  (A9F8L0), LONB_HALSA  (Q9HSC3), LONH_HAEIN  (P43865), 
LONM1_ARATH (P93655), LONM1_DICDI (Q54YV4), LONM3_ARATH (Q9M9L8), 
LONM4_ARATH (Q9M9L7), LONM_ASPFU  (Q4X0Z7), LONM_ASPNC  (A2QCJ2), 
LONM_BOVIN  (Q59HJ6), LONM_CAEBR  (A8XFM8), LONM_CAEEL  (O44952), 
LONM_CANGA  (Q6FPE6), LONM_DROME  (Q7KUT2), LONM_EMENI  (Q5AZT7), 
LONM_EREGS  (Q754Q9), LONM_HUMAN  (P36776), LONM_KLULA  (Q6CNR9), 
LONM_MAIZE  (P93648), LONM_MOUSE  (Q8CGK3), LONM_NEUCR  (Q7S8C4), 
LONM_ORYSI  (A2YQ56), LONM_ORYSJ  (Q69UZ3), LONM_OSTLU  (A4S6Y4), 
LONM_OSTTA  (Q00WL5), LONM_PHATC  (B7FSL4), LONM_RAT(Q924S5), 
LONM_SCHPO  (Q09769), LONM_YARLI  (Q6C0B5), LONM_YEAST  (P36775), 
LONP2_ARATH (O64948), LONP2_BOVIN (Q3SX23), LONP2_CANAL (Q59YV0), 
LONP2_CANDC (B9WEC4), LONP2_DANRE (Q5PQY6), LONP2_DEBHA (Q6BJJ8), 
LONP2_EREGS (Q755E4), LONP2_HUMAN (Q86WA8), LONP2_KLULA (Q6CWS4), 
LONP2_MAIZE (P93647), LONP2_MOUSE (Q9DBN5), LONP2_ORYSI (B8BDV1), 
LONP2_ORYSJ (Q0J032), LONP2_PICAN (Q2V573), LONP2_PICST (A3LUF7), 
LONP2_PONAB (Q5R6M5), LONP2_RAT   (Q3MIB4), LONP2_SPIOL (O04979), 
LONP2_XENLA (Q2TAF8), LONP2_YARLI (Q6C0L7), LON_ACIB3   (B7GXS7), 
LON_AMOA5   (B3ERM8), LON_ANADE   (Q2IIK1), LON_AQUAE   (O66605), 
LON_AYWBP   (Q2NJE3), LON_AZOBR   (P77810), LON_AZOC5   (A8HYF7), 
LON_BACAH   (A0RJ87), LON_BORDL   (B5RL78), LON_BRECH   (P36772), 
LON_BRUA2   (Q2YPX3), LON_BRUAB   (P0C113), LON_BRUME   (Q8YHC6), 
LON_BRUSU   (Q8G0I7), LON_BUCAI   (P57549), LON_BUCAP   (Q8K988), 
LON_BUCBP   (Q89A99), LON_CALS8   (A4XJL4), LON_CAMC1   (A7ZEJ3), 
LON_CAMJE   (O69300), LON_CAUVC   (P0CAW0), LON_CAUVN   (B8GX12), 
LON_CHLAA   (A9WGB5), LON_CHLMU   (Q9PK50), LON_CHLPN   (Q9Z9F4), 
LON_CHLT3   (B3QSJ7), LON_CHLTR   (O84348), LON_CITBB   (B5EDX8), 
LON_CLOAB   (Q97FT9), LON_CLOB8   (A6LSV5), LON_CLOD6   (Q180E4), 
LON_COPPD   (B5Y8Q8), LON_CYTH3   (Q11QT1), LON_DESAL   (B8F9K1), 
LON_DESDA   (B8J198), LON_DESOH   (A8ZX50), LON_DESRM   (A4J7L6), 
LON_DICNV   (A5EWF3), LON_DICT6   (B5YFG2), LON_ECOL6   (P0A9M1), 
LON_ECOLI   (P0A9M0), LON_ENDTX   (B1GZQ6), LON_ERWAM   (P46067), 
LON_FERNB   (A7HK39), LON_FINM2   (B0S2N4), LON_FLAJ1   (A5FG89), 
LON_FRAAA   (Q0RPW3), LON_FRAP2   (B0TZA7), LON_FUSNN   (Q8RHK0), 
LON_GEOMG   (Q39QP7), LON_HAEIN   (P43864), LON_HALOH   (B8CY71), 
LON_HELMI   (B0TFI9), LON_HELPJ   (Q9ZJL3), LON_HELPY   (P55995), 
LON_KARMG   (A8Z5Z0), LON_KORVE   (Q1IPZ8), LON_LACP7   (A9KH99), 
LON_LAWIP   (Q1MS21), LON_LEPIC   (Q72UP9), LON_MAGMM   (A0L516), 
LON_MALP2   (Q8EV77), LON_METBF   (Q469F5), LON_METSB   (B8EMF2), 
LON_METST   (Q2NEP8), LON_MYCGE   (P47481), LON_MYCMS   (Q6MTF4), 
LON_MYCPN   (P78025), LON_MYCSM   (O31147), LON_NEOSM   (Q2GE60), 
LON_NITOC   (Q3JBB6), LON_NITV2   (Q72CE6), LON_ORITI   (B3CUN9), 
LON_PARD8   (A6LD45), LON_PARPJ   (B2TFQ5), LON_PARUW   (Q6ME13), 
LON_PHEZH   (B4RI01), LON_PORG3   (B2RII6), LON_PSELT   (A8F811), 
LON_RHIME   (O69177), LON_RICBR   (Q1RID6), LON_RICCN   (Q92HZ1), 
LON_RICFE   (Q4ULN0), LON_RICPR   (Q9ZD92), LON_RICTY   (Q68WS8), 
LON_ROSCS   (A7NM80), LON_SALAI   (A8M1E8), LON_SHIDS   (Q32JJ5), 
LON_SOLUE   (Q026Q2), LON_SULSY   (B2V6N0), LON_SYNAS   (Q2LVS9), 
LON_SYNWW   (Q0AWF3), LON_TREPA   (O83536), LON_TRIL1   (B3E7K2), 
LON_UREP2   (B1AIY7), LON_XANOR   (Q5H432)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

34 sequences

LON2_SYNFM  (A0LG61), LON2_THET2  (Q72JM6), LONB_ARCFU  (O29883),

LONB_METJA  (Q58812), LONB_METTH  (O26878), LONB_PYRAB  (Q9UYC6), 
LONB_PYRHO  (O58221), LONB_THEKO  (Q8NKS6), LONB_THEVO  (P58274), 
LONH_ECOLI  (P75867), LONH_MIMIV  (Q5UPT0), LONM2_DICDI (Q550C8), 
LONM_CANAL  (Q5A6N1), LONM_CANDC  (B9WLN5), LONM_CRYNB  (P0CQ17), 
LONM_CRYNJ  (P0CQ16), LONM_DEBHA  (Q6BKJ4), LONM_PICST  (A3M072), 
LONP2_ASPFU (Q4WVD9), LONP2_ASPNC (A2RAF6), LONP2_CAEBR (A8Y3E2), 
LONP2_CAEEL (Q9XW87), LONP2_EMENI (Q5BH58), LONP2_NEUCR (Q7SA85), 
LON_CHLAD   (B8G736), LON_DEIRA   (Q9RXG4), LON_ELUMP   (B2KCC0), 
LON_MESH2   (Q600B5), LON_META1   (B3PN08), LON_MYCAP   (A5IYF2), 
LON_MYCM1   (Q6KI22), LON_MYCS5   (Q4A696), LON_VIBPA   (P74956), 
LON_WOLPP   (B3CLB3)

» more

PDB
[Detailed view]

30 PDB

pdb_00002x36; pdb_00006wys; pdb_00006wzv; pdb_00006x1m; pdb_00006x27; pdb_00007krz; pdb_00007ksl; pdb_00007ksm; pdb_00007nfy; pdb_00007ng4; pdb_00007ng5; pdb_00007ngc; pdb_00007ngf; pdb_00007ngl; pdb_00007ngp; pdb_00007ngq; pdb_00007oxo; pdb_00007p09; pdb_00007p0b; pdb_00007p0m; pdb_00007p6u; pdb_00007sxo; pdb_00008dvh; pdb_00008ojl; pdb_00008oka; pdb_00008om7; pdb_00008ovf; pdb_00008ovg; pdb_00009cc0; pdb_00009cc3
» more