We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE entry PS01047
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PURL: https://purl.expasy.org/prosite/signature/PS01047
Direct ScanProsite submission
General information about the entry
| Entry name [info] | HMA_1 |
| Accession [info] | PS01047 |
| Entry type [info] | PATTERN |
| Date [info] |
01-NOV-1995 CREATED;
01-APR-2006 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00804 |
Name and characterization of the entry
| Description [info] | Heavy-metal-associated domain. |
| Pattern [info] |
[LIVNS]-x-{L}-[LIVMFA]-x-C-x-[STAGCDNH]-C-x(3)-[LIVFG]-{LV}-x(2)-[LIV]-
x(9,11)-[IVA]-x-[LVFYS].
|
Numerical results [info]
| Total number of hits | 222 in 153 different sequences |
| Number of true positive hits | 207 in 138 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 15 in 15 different sequences |
| Number of false negative sequences | 63 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 93.24 % |
| Recall (true positives / (true positives + false negatives)) | 76.67 % |
Comments [info]
| Taxonomic range [info] | Archaea, Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 6 |
| Site [info] | metal(?) at position 6 |
| Site [info] | metal(?) at position 9 |
| Version [info] | 2 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
138 sequences
ATCS_SYNE7 (P37279), ATCS_SYNY3 (P73241), ATCU1_RHIME (P58341), ATCU2_RHIME (P58342), ATCU_SINMW (Q9X5X3), ATOX1_BOVIN (Q3T0E0), ATOX1_CANLF (Q9TT99), ATOX1_HUMAN (O00244), ATOX1_MOUSE (O08997), ATOX1_RAT (Q9WUC4), ATOX1_SHEEP (Q9XT28), ATP7A_CRIGR (P49015), ATP7A_HUMAN (Q04656), ATP7A_MOUSE (Q64430), ATP7A_RAT (P70705), ATP7B_HUMAN (P35670), ATP7B_MOUSE (Q64446), ATP7B_RAT (Q64535), ATP7B_SHEEP (Q9XT50), ATSY_SYNE7 (P37385), ATSY_SYNP6 (P07893), ATU2_SCHPO (O59666), ATU2_YEAST (P38995), ATX1_SCHPO (O74735), ATX1_YEAST (P38636), ATZN_SYNY3 (Q59998), CADA1_STAAU (P20021), CADA2_STAAU (P37386), CADA_ALKPO (P30336), CADA_BACSU (O32219), CADA_LISMN (Q60048), CADA_LISMO (P58414), CADA_STAAR (Q6GIX1), COPA1_HELPX (P77871), COPA2_HELPX (Q59467), COPA3_HELPX (O08462), COPA_ARCFU (O29777), COPA_BACSU (O32220), COPA_ECO57 (Q8XD24), COPA_ECOLI (Q59385), COPA_ENTHA (P32113), COPA_HELFC (O32619), COPA_HELPJ (Q9ZM69), COPA_HELPY (P55989), COPA_SALTI (Q8Z8S4), COPA_SALTY (Q8ZR95), COPA_STAA1 (A7X6S1), COPA_STAA2 (A6U4T8), COPA_STAA3 (Q2FDV0), COPA_STAA8 (Q2FV64), COPA_STAA9 (A5IVY3), COPA_STAAB (Q2YWA3), COPA_STAAC (Q5HCZ3), COPA_STAAE (A6QK47), COPA_STAAM (Q99R80), COPA_STAAN (Q7A3E6), COPA_STAAR (Q6GDP1), COPA_STAAS (Q6G6B7), COPA_STAAT (A8Z3F8), COPA_STAAW (Q8NUQ9), COPA_STAEQ (Q5HL56), COPA_STAES (Q8CN02), COPA_STAHJ (Q4L970), COPA_STAS1 (Q4A0G1), COPA_VIBCH (Q9KPZ7), COPA_YERPE (Q8ZCA7), COPP_HELFC (O32620), COPP_HELPJ (Q9ZM70), COPP_HELPY (Q48271), COPZ_ARCFU (O29901), COPZ_BACSU (O32221), COPZ_ENTHA (Q47840), COPZ_STAA1 (A7X6S3), COPZ_STAA2 (A6U4T9), COPZ_STAA3 (Q2FDU9), COPZ_STAA8 (Q2FV63), COPZ_STAA9 (A5IVY4), COPZ_STAAB (P0C885), COPZ_STAAC (Q5HCZ2), COPZ_STAAE (A6QK48), COPZ_STAAM (Q99R79), COPZ_STAAN (Q7A3E5), COPZ_STAAR (Q6GDP0), COPZ_STAAS (Q6G6B6), COPZ_STAAT (A8Z3F9), COPZ_STAAW (Q79ZY4), COPZ_STAEQ (Q5HL55), COPZ_STAES (Q8CN01), COPZ_STAHJ (Q4L971), COPZ_STAS1 (Q4A0G2), CTPA_MYCLE (P46839), CTPA_MYCTO (P9WPU0), CTPA_MYCTU (P9WPU1), CTPB_MYCBO (P59947), CTPB_MYCLE (P46840), CTPB_MYCTO (P9WPT8), CTPB_MYCTU (P9WPT9), FIXI_BRADU (Q59207), FIXI_RHILV (O33533), FIXI_RHIME (P18398), HIP24_ARATH (O81464), HIP45_ARATH (B3H6D0), HMA4_ORYSJ (Q6H7M3), HMA5_ARATH (Q9SH30), HMA5_ORYSJ (A3AWA4), HMA6_ARATH (Q9SZC9), HMA7_ARATH (Q9S7J8), HMA9_ORYSJ (A0A0P0X004), HMCT_HELPJ (Q9ZL53), HMCT_HELPY (Q59465), MEB2_ARATH (F4KFS7), MERA_ACICA (Q52109), MERA_ACIFR (P17239), MERA_ALCSP (P94188), MERA_BACCE (P16171), MERA_ENTAG (P94702), MERA_PSEAI (P00392), MERA_PSEFL (Q51772), MERA_SERMA (P08662), MERA_SHEPU (Q54465), MERA_SHIFL (P08332), MERA_STAAU (P0A0E5), MERA_STAES (P0A0E4), MERP_ACICA (Q52107), MERP_ALCSP (P94186), MERP_ENTAG (P0A217), MERP_ENTCL (P0A218), MERP_PSEAI (P04131), MERP_PSEFL (Q51770), MERP_SALTI (P0A216), MERP_SERMA (P13113), MERP_SHEPU (Q54463), MERP_SHIFL (P04129), Y290_HAEIN (P77868), Y291_HAEIN (P43979), Y292_HAEIN (O32622), ZNTA_ECOLI (P37617), ZNTA_SHISS (Q3YW59)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
63 sequences
ATOX1_ARATH (Q94BT9), ATOX1_DICDI (Q54PZ2), ATU1_YEAST (P38360), CCH_ARATH (O82089), CCS1_CANGA (Q6FU61), CCS1_DEBHA (Q6BK66), CCS1_EREGS (Q75DD6), CCS1_KLULA (Q6CIG2), CCS1_YARLI (Q6BZU2), CCS1_YEAST (P40202), CCS_ARATH (Q9LD47), CCS_DICDI (Q54F73), CCS_HUMAN (O14618), CCS_MOUSE (Q9WU84), CCS_ORYSJ (Q7XTY9), CCS_RAT (Q9JK72), HIP15_ARATH (Q9CAK6), HIP17_ARATH (Q9FVS0), HIP18_ARATH (Q9T0K9), HIP19_ARATH (A0JPW5), HIP1_ARATH (Q9ZUV1), HIP20_ARATH (Q9C9A3), HIP21_ARATH (Q9LF57), HIP22_ARATH (Q93VP2), HIP23_ARATH (O65657), HIP25_ARATH (O49613), HIP26_ARATH (Q9SZN7), HIP27_ARATH (Q67ZW1), HIP28_ARATH (F4IC29), HIP29_ARATH (Q9LP41), HIP2_ARATH (Q8GWS3), HIP30_ARATH (F4IQG4), HIP31_ARATH (Q84K70), HIP32_ARATH (Q9M8K5), HIP33_ARATH (F4JZL7), HIP34_ARATH (Q0WV37), HIP35_ARATH (Q9C7J6), HIP36_ARATH (Q84J88), HIP37_ARATH (A2RVM8), HIP39_ARATH (O03982), HIP3_ARATH (Q9FJH5), HIP41_ARATH (F4I1X0), HIP42_ARATH (Q9CAV5), HIP43_ARATH (Q9SFF7), HIP44_ARATH (F4JMB8), HIP4_ARATH (Q9SHQ8), HIP5_ARATH (Q9SJL2), HIP6_ARATH (Q9LZF1), HIP7_ARATH (Q9C5D3), HIP8_ARATH (Q9M8T7), HIP9_ARATH (Q9FLU5), HMA2_ARATH (Q9SZW4), HMA2_ORYSJ (A3BF39), HMA3A_ARATH (P0CW77), HMA3B_ARATH (P0CW78), HMA3_ORYSJ (Q8H384), HMA4_ARATH (O64474), HMCT_HELFE (Q9RQB4), NAKR1_ARATH (Q8LDS4), NAKR2_ARATH (Q58FZ0), NAKR3_ARATH (Q8RXH8), PI21_ORYSI (A2XT03), PI21_ORYSJ (Q7XL73)» more |
| UniProtKB/Swiss-Prot False positive sequences |
15 sequences
CSPL7_ORYSJ (Q6YT98), CYC6_GRATL (Q6B941), CYC6_LIMMA (P00118), CYC6_MICAE (P00112), DDX47_DROME (Q9VIF6), GPI7_YEAST (P40367), HMGB7_ARATH (Q8LDF9), NU5C_NEPOL (Q9TKV7), QRIC2_MOUSE (Q3V2A7), R32DT_HUMAN (Q8NI28), RECO_LEIXX (Q6AED5), SYFA_THEFY (Q47N75), UD2A3_HUMAN (Q6UWM9), UD2A3_PONAB (Q5RFJ3), YAB4_ARATH (Q9LDT3)» more |
| PDB [Detailed view] |
92 PDB
pdb_00001afi; pdb_00001afj; pdb_00001aw0; pdb_00001cc7; pdb_00001cc8; pdb_00001cpz; pdb_00001fd8; pdb_00001fe0; pdb_00001fe4; pdb_00001fee; pdb_00001fes; pdb_00001fvq; pdb_00001fvs; pdb_00001jww; pdb_00001k0v; pdb_00001kqk; pdb_00001kvi; pdb_00001kvj; pdb_00001mwy; pdb_00001mwz; pdb_00001opz; pdb_00001oq3; pdb_00001oq6; pdb_00001p6t; pdb_00001p8g; pdb_00001q8l; pdb_00001s6o; pdb_00001s6u; pdb_00001tl4; pdb_00001tl5; pdb_00001y3j; pdb_00001y3k; pdb_00001yg0; pdb_00001yjr; pdb_00001yjt; pdb_00001yju; pdb_00001yjv; pdb_00002aj0; pdb_00002aj1; pdb_00002aw0; pdb_00002ew9; pdb_00002g9o; pdb_00002ga7; pdb_00002gcf; pdb_00002ggp; pdb_00002hqi; pdb_00002k1r; pdb_00002kt2; pdb_00002kt3; pdb_00002ldi; pdb_00002lq9; pdb_00002lqb; pdb_00002n7y; pdb_00002ofg; pdb_00002ofh; pdb_00002qif; pdb_00002rml; pdb_00002rop; pdb_00002voy; pdb_00002xmw; pdb_00003cjk; pdb_00003dxs; pdb_00003fry; pdb_00003i9z; pdb_00003iwl; pdb_00003iwx; pdb_00003k7r; pdb_00004a48; pdb_00004a4j; pdb_00004qot; pdb_00004umv; pdb_00004umw; pdb_00004ydx; pdb_00004yea; pdb_00005f0w; pdb_00005t7l; pdb_00005vde; pdb_00005vdf; pdb_00006a71; pdb_00006a72; pdb_00006ff2; pdb_00007dc1; pdb_00007xuk; pdb_00007xum; pdb_00007xun; pdb_00007xuo; pdb_00007zc3; pdb_00008ioy; pdb_00008q73; pdb_00008q74; pdb_00008q75; pdb_00008q76 » more |