PROSITE entry PS01095

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PURL: https://purl.expasy.org/prosite/signature/PS01095

Direct ScanProsite submission

General information about the entry

Entry name [info]	GH18_1
Accession [info]	PS01095
Entry type [info]	PATTERN
Date [info]	01-NOV-1995 CREATED; 01-NOV-1995 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00839
Associated ProRule [info]	PRU10053

Name and characterization of the entry

Description [info]	Glycosyl hydrolases family 18 (GH18) active site signature.
Pattern [info]	[LIVMFY]-[DN]-G-[LIVMF]-[DN]-[LIVMF]-[DN]-x-E.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	114 in 113 different sequences
Number of true positive hits	102 in 101 different sequences
Number of 'unknown' hits	0
Number of false positive hits	12 in 12 different sequences
Number of false negative sequences	44
Number of 'partial' sequences	6

Precision (true positives / (true positives + false positives))	89.47 %
Recall (true positives / (true positives + false negatives))	69.86 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info]	2
Site [info]	active_site at position 9
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	101 sequences CHI10_DROME (Q9W5U2), CHI18_ENTFA (Q838S2), CHI1_APHAL (P32470), CHI1_ARTBC (D4AT07), CHI1_CANAL (Q5AAH2), CHI1_CANAX (P46876), CHI1_COCIM (Q1E3R8), CHI1_COCP7 (C5P230), CHI1_COCPS (P0CB51), CHI1_METAN (O14456), CHI1_METRA (E9ERT9), CHI1_PINMG (H2A0L4), CHI1_RHINI (P29025), CHI1_RHIOL (P29026), CHI2_ARTBC (D4AVJ0), CHI2_CANAL (P40953), CHI2_COCIM (Q1EAR5), CHI2_COCP7 (P54197), CHI2_METAN (Q4U4T0), CHI2_METRA (E9F9R9), CHI2_PINMG (H2A0L5), CHI2_RHIOL (P29027), CHI2_YEAST (Q06350), CHI33_ARTBC (D4B4X4), CHI33_TRIHA (Q12713), CHI37_TRIHA (Q8NJQ5), CHI3_CANAL (P40954), CHI3_METAN (Q6QDR4), CHI3_METRA (E9ENC6), CHI42_TRIHA (P48827), CHI46_TRIHA (A6N6J0), CHI4_CANAL (Q5AM60), CHI4_METAN (C9WJD0), CHI4_METRA (E9F7R6), CHI52_PAEXY (A0A8G1A3Q5), CHIA1_ASPFM (Q873Y0), CHIA1_ASPFU (Q4WEP7), CHIA1_ASPNC (A2QUQ2), CHIA1_EMEND (Q92223), CHIA1_EMENI (G5EB30), CHIA1_NIACI (P20533), CHIA_ARATH (P19172), CHIA_BOVIN (Q95M17), CHIA_CICAR (P36908), CHIA_CUCSA (P17541), CHIA_FLAJ1 (A5FB63), CHIA_HUMAN (Q9BZP6), CHIA_MOUSE (Q91XA9), CHIA_PHAAN (P29024), CHIA_PSEO7 (P32823), CHIA_RAT(Q6RY07), CHIA_SERMA (P07254), CHIA_TOBAC (P29060), CHIB1_ASPFM (Q873X9), CHIB1_ASPFU (E9QRF2), CHIB1_EMENI (G5EAZ3), CHIB_EMEND (Q92222), CHIB_SERMA (P11797), CHIB_TOBAC (P29061), CHID_NIACI (P27050), CHIE_BETVU (P36910), CHIT1_HUMAN (Q13231), CHIT1_MOUSE (Q9D7Q1), CHIT1_TULSB (Q9SLP4), CHIT2_DROME (Q9W092), CHIT2_TULSB (Q7M443), CHIT3_VITVI (P51614), CHIT5_LOTJA (A0A1B1J8Z2), CHIT_BRUMA (P29030), CHIT_CAEEL (Q11174), CHIT_MANSE (P36362), CHIT_NPVAC (P41684), CHIT_NPVOP (O10363), CHIT_PLAF7 (Q8I4R4), CHIT_PUNGR (G1UH28), CHIT_STRLI (P36909), CHIT_STRPL (P11220), CHIT_YEAST (P29029), CHIX_STROI (Q05638), CHI_PINMA (P86955), CHLY_HEVBR (P23472), CHT5A_MEDTR (A0A072VEP0), CHT5B_MEDTR (A0A072UR65), DIAC_BOVIN (Q01458), DIAC_HUMAN (Q01459), DIAC_MOUSE (Q8R242), DIAC_RAT(Q01460), EBA2_ELIME (P36912), EBAG_FLAST (P80036), EBAG_STRPL (P04067), EBI1_BIFLS (B7GPC7), ENDOS_STRP1 (Q99Y92), ENDS2_STRP9 (T1WGN1), ENDSD_STRDY (A0A191T6Q6), KTXA_KLULA (P09805), LYS11_PENEN (A0A0A2J9B0), LYS12_PENEN (A0A0A2JP37), LYS18_PENEN (A0A0A2JVV3), NFH1_MEDTR (U5N4E3), PPG1_CANAL (Q5A6B6), YKVQ_BACSU (O31682) » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	44 sequences CH3L1_BOVIN (P30922), CH3L1_BUBBU (Q7YS85), CH3L1_CAPHI (Q8SPQ0), CH3L1_HUMAN (P36222), CH3L1_MOUSE (Q61362), CH3L1_PIG (Q29411), CH3L1_PONAB (Q5RBP6), CH3L1_RAT (Q9WTV1), CH3L1_SHEEP (Q6TMG6), CH3L2_HUMAN (Q15782), CHIA_ECOLI (P13656), CHID1_BOVIN (Q5EAB4), CHID1_DANRE (Q7SYK0), CHID1_DICDI (Q54G42), CHID1_HUMAN (Q9BWS9), CHID1_MOUSE (Q922Q9), CHID1_PONAB (Q5RFF6), CHID1_RAT (A0JPQ9), CHID1_XENLA (Q68EX9), CHID1_XENTR (Q66IL0), CHID_VIBFU (P96156), CHITL_CAEEL (Q18143), CHIT_SACEN (P14529), CHL18_DERFA (Q86R84), CHL18_DERPT (Q4JK71), CONB_CANEN (P49347), DIAC1_DICDI (Q7KWW8), DIAC2_DICDI (Q8T293), EBA1_ELIME (P36911), EBA3_ELIME (P36913), OVGP1_BOVIN (Q28042), OVGP1_HUMAN (Q12889), OVGP1_MESAU (Q60557), OVGP1_MOUSE (Q62010), OVGP1_PAPAN (P36718), OVGP1_PIG (Q28990), OVGP1_SHEEP (Q28542), XIP1_ORYSJ (Q7GCM7), XIP1_WHEAT (Q8L5C6), XIP2_ORYSJ (Q53NL5), XIP_ORYSJ (Q5WMW5), YDHD_BACSU (O05495), YKZR_BACSU (C0H404), YVBX_BACSU (O32258) » more
UniProtKB/Swiss-Prot 'Partial' sequences	6 sequences CAI_PHAVU (P84708), CHI1_STROI (P29115), CHI2_STROI (P29116), CHIT_STRVL (P84754), CHLY_PARTH (P23473), NAHA1_PALCA (P85512) » more
UniProtKB/Swiss-Prot False positive sequences	12 sequences CAPSD_CPVBM (Q6TS43), CAPSD_LDCPR (Q91IE1), CCNL2_XENTR (Q5BKF8), HISX_CALS4 (Q8R882), HSCB_ARATH (Q8L7K4), NU4C_PROM0 (A3PAL7), NU4C_PROM2 (A8G2F5), NU4C_PROM5 (A2BUC6), NU4C_PROM9 (Q31D31), NU4C_PROMP (Q7V3C8), SSUB2_RHIJ3 (Q1M7A6), TRPM2_HUMAN (O94759) » more
PDB [Detailed view]	114 PDB pdb_00001c3f; pdb_00001ctn; pdb_00001d2k; pdb_00001edt; pdb_00001ffq; pdb_00001ffr; pdb_00001goi; pdb_00001guv; pdb_00001h0g; pdb_00001h0i; pdb_00001hki; pdb_00001hkj; pdb_00001hkk; pdb_00001hkm; pdb_00001hvq; pdb_00001itx; pdb_00001k9t; pdb_00001lg1; pdb_00001lg2; pdb_00001ll4; pdb_00001ll6; pdb_00001llo; pdb_00001lq0; pdb_00001o6i; pdb_00001ogb; pdb_00001ogg; pdb_00001rd6; pdb_00001w9p; pdb_00001w9u; pdb_00001w9v; pdb_00001waw; pdb_00001wb0; pdb_00001wno; pdb_00001x6l; pdb_00001x6n; pdb_00002a3a; pdb_00002a3b; pdb_00002a3c; pdb_00002a3e; pdb_00002hvm; pdb_00002iuz; pdb_00002uy2; pdb_00002uy3; pdb_00002uy4; pdb_00002uy5; pdb_00002wk2; pdb_00002wly; pdb_00002wlz; pdb_00002wm0; pdb_00002xuc; pdb_00002xvn; pdb_00002ybt; pdb_00002ybu; pdb_00003ch9; pdb_00003chc; pdb_00003chd; pdb_00003che; pdb_00003chf; pdb_00003fxy; pdb_00003fy1; pdb_00003rm4; pdb_00003rm8; pdb_00003rm9; pdb_00003rme; pdb_00003wd0; pdb_00003wd1; pdb_00003wd2; pdb_00003wd3; pdb_00003wd4; pdb_00004nuy; pdb_00004toq; pdb_00004txe; pdb_00004wjx; pdb_00004wk9; pdb_00004wka; pdb_00004wkf; pdb_00004wkh; pdb_00004z2g; pdb_00004z2h; pdb_00004z2i; pdb_00004z2j; pdb_00004z2k; pdb_00004z2l; pdb_00005hbf; pdb_00005nr8; pdb_00005nra; pdb_00005nrf; pdb_00006e58; pdb_00006epb; pdb_00006jjr; pdb_00006jk6; pdb_00006jk9; pdb_00006jkf; pdb_00006ldu; pdb_00006le7; pdb_00006le8; pdb_00006mds; pdb_00006mdv; pdb_00006ve1; pdb_00006ze8; pdb_00007c34; pdb_00007c92; pdb_00007cb1; pdb_00007fd6; pdb_00007zya; pdb_00008fg5; pdb_00008fg7; pdb_00008fr9; pdb_00008fra; pdb_00008frb; pdb_00008frc; pdb_00008frd; pdb_00008frg; pdb_00008gca » more