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PROSITE entry PS01121


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PURL: https://purl.expasy.org/prosite/signature/PS01121

Direct ScanProsite submission
General information about the entry

Entry name [info] CASPASE_HIS
Accession [info] PS01121
Entry type [info] PATTERN
Date [info] 01-NOV-1995 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00864

Name and characterization of the entry

Description [info] Caspase family histidine active site.
Pattern [info] 
H-x(2,4)-[SC]-x(2)-{A}-x-[LIVMF](2)-[ST]-H-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 69 in 69 different sequences
Number of true positive hits 58 in 58 different sequences
Number of 'unknown' hits 1
Number of false positive hits 10 in 10 different sequences
Number of false negative sequences 4
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 85.29 %
Recall (true positives / (true positives + false negatives)) 93.55 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] active_site at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 58 sequences 

CAS1A_XENLA (P55865), CAS1B_XENLA (P55867), CASP1_CANLF (Q9MZV7), 

CASP1_DROME (O02002), CASP1_FELCA (Q9MZV6), CASP1_HORSE (Q9TV13), 
CASP1_HUMAN (P29466), CASP1_MOUSE (P29452), CASP1_PIG   (Q9N2I1), 
CASP1_RAT   (P43527), CASP1_SPOFR (P89116), CASP2_CHICK (Q98943), 
CASP2_HUMAN (P42575), CASP2_MOUSE (P29594), CASP2_RAT   (P55215), 
CASP3_BOVIN (Q08DY9), CASP3_CANLF (Q8MKI5), CASP3_FELCA (Q8MJU1), 
CASP3_HUMAN (P42574), CASP3_MACFA (Q2PFV2), CASP3_MESAU (Q60431), 
CASP3_MOUSE (P70677), CASP3_PANTR (Q5IS54), CASP3_PIG   (Q95ND5), 
CASP3_RABIT (Q8MJC3), CASP3_RAT   (P55213), CASP3_SAIBB (Q5IS99), 
CASP3_XENLA (P55866), CASP4_BOVIN (Q5E9C1), CASP4_HUMAN (P49662), 
CASP4_MOUSE (P70343), CASP5_HUMAN (P51878), CASP6_BOVIN (Q3T0P5), 
CASP6_HUMAN (P55212), CASP6_MOUSE (O08738), CASP6_RAT   (O35397), 
CASP7_CHICK (F1NV61), CASP7_HUMAN (P55210), CASP7_MESAU (P55214), 
CASP7_MOUSE (P97864), CASP8_HUMAN (Q14790), CASP8_MOUSE (O89110), 
CASP8_RAT   (Q9JHX4), CASP9_HUMAN (P55211), CASP9_MOUSE (Q8C3Q9), 
CASPA_DANRE (Q9I9L7), CASPA_HUMAN (Q92851), CASPB_DANRE (Q504J1), 
CASPC_CANLF (Q075B4), CASPC_MACMU (Q153Z0), CASPC_MOUSE (O08736), 
CASPC_RAT   (Q920D5), CASPD_BOVIN (O75601), CED3_CAEEL  (P42573), 
CED3_CAERE  (P45436), CSP1_CAEEL  (G5EBM1), CSP2_CAEEL  (Q9TZP5), 
DRICE_DROME (O01382)
» more

UniProtKB/Swiss-Prot
False negative sequences		 4 sequences 

CASP8_DROME (Q8IRY7), CASPE_HUMAN (P31944), CASPE_MOUSE (O89094), 

DRONC_DROME (Q9XYF4)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

PHIA_FUNX7  (A0A348HAX6)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			10 sequences
			


			
ACCC_ALLVD  (O52058), CESAA_ARATH (Q9SKJ5), FENR_STAS1  (Q49ZU9), 

			
ICH_DROME   (Q9VHJ6), PARP2_HUMAN (Q9UGN5), PARP2_MOUSE (O88554), 
RN133_MACFA (Q95K04), RPOD_BUCAP  (P32001), SUGPH_MYCTU (Q6MWZ7), 
TDRD5_DANRE (Q1L981)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			273 PDB
			


			pdb_00001bmq; pdb_00001cp3; pdb_00001f1j; pdb_00001f9e; pdb_00001gfw; pdb_00001gqf; pdb_00001i3o; pdb_00001i4e; pdb_00001i4o; pdb_00001i51; pdb_00001ibc; pdb_00001ice; 
			
				pdb_00001jxq; pdb_00001k86; pdb_00001k88; pdb_00001kmc; pdb_00001m72; pdb_00001nme; pdb_00001nmq; pdb_00001nms; pdb_00001nw9; pdb_00001pau; pdb_00001pyo; pdb_00001qdu; 
				pdb_00001qtn; pdb_00001qx3; pdb_00001re1; pdb_00001rhj; pdb_00001rhk; pdb_00001rhm; pdb_00001rhq; pdb_00001rhr; pdb_00001rhu; pdb_00001rwk; pdb_00001rwm; pdb_00001rwn; 
				pdb_00001rwo; pdb_00001rwp; pdb_00001rwv; pdb_00001rww; pdb_00001rwx; pdb_00001sc1; pdb_00001sc3; pdb_00001sc4; pdb_00001shj; pdb_00001shl; pdb_00002ar9; pdb_00002c1e; 
				pdb_00002c2k; pdb_00002c2m; pdb_00002c2o; pdb_00002c2z; pdb_00002cdr; pdb_00002cjx; pdb_00002cjy; pdb_00002cnk; pdb_00002cnl; pdb_00002cnn; pdb_00002cno; pdb_00002dko; 
				pdb_00002fqq; pdb_00002fun; pdb_00002h48; pdb_00002h4w; pdb_00002h4y; pdb_00002h51; pdb_00002h54; pdb_00002h5i; pdb_00002h5j; pdb_00002h65; pdb_00002hbq; pdb_00002hbr; 
				pdb_00002hby; pdb_00002hbz; pdb_00002j30; pdb_00002j31; pdb_00002j32; pdb_00002j33; pdb_00002k7z; pdb_00002p2c; pdb_00002ql5; pdb_00002ql7; pdb_00002ql9; pdb_00002qlb; 
				pdb_00002qlf; pdb_00002qlj; pdb_00002wdp; pdb_00002xyg; pdb_00002xyh; pdb_00002xyp; pdb_00002xzd; pdb_00002xzt; pdb_00002y0b; pdb_00002y1l; pdb_00003d6f; pdb_00003d6h; 
				pdb_00003d6m; pdb_00003deh; pdb_00003dei; pdb_00003dej; pdb_00003dek; pdb_00003e4c; pdb_00003edq; pdb_00003edr; pdb_00003gjq; pdb_00003gjr; pdb_00003gjs; pdb_00003gjt; 
				pdb_00003h0e; pdb_00003h11; pdb_00003h1p; pdb_00003ibc; pdb_00003ibf; pdb_00003itn; pdb_00003k7e; pdb_00003kjf; pdb_00003kjn; pdb_00003kjq; pdb_00003nkf; pdb_00003nr2; 
				pdb_00003ns7; pdb_00003od5; pdb_00003p45; pdb_00003p4u; pdb_00003pcx; pdb_00003pd0; pdb_00003pd1; pdb_00003qnw; pdb_00003r5j; pdb_00003r5k; pdb_00003r6g; pdb_00003r6l; 
				pdb_00003r7b; pdb_00003r7n; pdb_00003r7s; pdb_00003rjm; pdb_00003s70; pdb_00003s8e; pdb_00003sip; pdb_00003sir; pdb_00003v3k; pdb_00003v6l; pdb_00003v6m; pdb_00004dcj; 
				pdb_00004dco; pdb_00004dcp; pdb_00004eha; pdb_00004ehd; pdb_00004ehf; pdb_00004ehh; pdb_00004ehk; pdb_00004ehl; pdb_00004ehn; pdb_00004ejf; pdb_00004fdl; pdb_00004fea; 
				pdb_00004fxo; pdb_00004hq0; pdb_00004hqr; pdb_00004hva; pdb_00004jb8; pdb_00004jj7; pdb_00004jj8; pdb_00004jje; pdb_00004jqy; pdb_00004jqz; pdb_00004jr0; pdb_00004jr1; 
				pdb_00004jr2; pdb_00004lsz; pdb_00004m9r; pdb_00004n5d; pdb_00004n6g; pdb_00004n7j; pdb_00004n7m; pdb_00004nbk; pdb_00004nbl; pdb_00004nbn; pdb_00004pry; pdb_00004prz; 
				pdb_00004ps0; pdb_00004ps1; pdb_00004qtx; pdb_00004qty; pdb_00004qu0; pdb_00004qu5; pdb_00004qu8; pdb_00004qu9; pdb_00004qua; pdb_00004qub; pdb_00004qud; pdb_00004que; 
				pdb_00004qug; pdb_00004quh; pdb_00004qui; pdb_00004quj; pdb_00004qul; pdb_00004zvo; pdb_00004zvp; pdb_00004zvq; pdb_00004zvr; pdb_00004zvs; pdb_00004zvt; pdb_00004zvu; 
				pdb_00005i9b; pdb_00005i9t; pdb_00005iab; pdb_00005iae; pdb_00005iag; pdb_00005iaj; pdb_00005iak; pdb_00005ian; pdb_00005iar; pdb_00005ias; pdb_00005ibc; pdb_00005ibp; 
				pdb_00005ibr; pdb_00005ic4; pdb_00005ic6; pdb_00005k20; pdb_00005mmv; pdb_00005mtk; pdb_00005v6u; pdb_00005v6z; pdb_00006bz9; pdb_00006deu; pdb_00006dev; pdb_00006f6r; 
				pdb_00006kmt; pdb_00006kmu; pdb_00006kmv; pdb_00006kmz; pdb_00006kn0; pdb_00006kn1; pdb_00006nry; pdb_00006ns7; pdb_00006px9; pdb_00006pzp; pdb_00006vie; pdb_00007wr0; 
				pdb_00007wr1; pdb_00007wr4; pdb_00007wr5; pdb_00007wr6; pdb_00007wzs; pdb_00007xn4; pdb_00007xn5; pdb_00007xn6; pdb_00008dgz; pdb_00008dj3; pdb_00008eg5; pdb_00008eg6; 
				pdb_00008f78; pdb_00008f96; pdb_00008f97; pdb_00008f98; pdb_00008f99; pdb_00008f9a; pdb_00008f9b; pdb_00008f9c; pdb_00008f9d; pdb_00008fbv; pdb_00008j6k; pdb_00008jol; 
				pdb_00008spb; pdb_00008sv1; pdb_00008wra; pdb_00008ybx; pdb_00008yni; pdb_00008ynk; pdb_00008ynl; pdb_00008ynm; pdb_00008ynn
			
			

			» more