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PROSITE documentation PDOC00867 [for PROSITE entry PS01126]

Elongation factor Ts signatures





Description

In prokaryotes elongation factor Ts (EF-Ts) is a component of the elongation cycle of protein biosynthesis. It associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP, it remains bound to the aminoacyl-tRNA. EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome [1].

EF-Ts is also a component of the chloroplast protein biosynthetic machinery and is encoded in the genome of some algal chloroplast [2]. It is also present in mitochondria [3].

As signature patterns for EF-Ts, we selected two conserved regions located in the N-terminal part of the protein.

Last update:

December 2004 / Pattern and text revised.

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Technical section

PROSITE methods (with tools and information) covered by this documentation:

EF_TS_1, PS01126; Elongation factor Ts signature 1  (PATTERN)

EF_TS_2, PS01127; Elongation factor Ts signature 2  (PATTERN)


References

1AuthorsBubunenko M.G. Kireeva M.L. Gudkov A.T.
TitleNovel data on interactions of elongation factor Ts.
SourceBiochimie 74:419-425(1992).
PubMed ID1637866

2AuthorsKostrzewa M. Zetsche K.
TitleOrganization of plastid-encoded ATPase genes and flanking regions including homologues of infB and tsf in the thermophilic red alga Galdieria sulphuraria.
SourcePlant Mol. Biol. 23:67-76(1993).
PubMed ID8219057

3AuthorsXin H. Woriax V.L. Burkhart W. Spremulli L.L.
TitleCloning and expression of mitochondrial translational elongation factor Ts from bovine and human liver.
SourceJ. Biol. Chem. 270:17243-17249(1995).
PubMed ID7615523



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