The following bacterial proteins, which seems to belong to a family of
pseudouridine synthases (EC 5.4.99.-) [1] have been shown to share regions of
similarities:
Escherichia coli and Haemophilus influenzae 16S pseudouridylate 516
synthase (EC 5.4.99.-) (gene: rsuA). This enzyme is responsible for the
formation of pseudouridine from uracil-516 in 16S ribosomal RNA.
Escherichia coli and Haemophilus influenzae ribosomal large subunit
pseudouridine synthase B (rluB).
Bacillus subtilis ribosomal large subunit pseudouridine synthase B (rluB).
Escherichia coli ribosomal large subunit pseudouridine synthase F (rluF).
Escherichia coli and Haemophilus influenzae ribosomal large subunit
pseudouridine synthase E (rluE).
Aquifex aeolicus hypothetical protein AQ_554.
Aquifex aeolicus hypothetical protein AQ_1464.
Bacillus subtilis hypothetical protein ytzF.
Borrelia burgdorferi hypothetical protein BB0129.
Helicobacter pylori hypothetical protein HP1459.
Synechocystis strain PCC 6803 hypothetical protein slr0361.
Synechocystis strain PCC 6803 hypothetical protein slr0612.
These are proteins of from 25 to 40 Kd which contain a number of conserved
regions in their central section. They can be picked up in the database by the
following highly conserved pattern.
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