PROSITE documentation PDOC00885 [for PROSITE entry PS01149]

Rsu family of pseudouridine synthase signature





Description

The following bacterial proteins, which seems to belong to a family of pseudouridine synthases (EC 5.4.99.-) [1] have been shown to share regions of similarities:

  • Escherichia coli and Haemophilus influenzae 16S pseudouridylate 516 synthase (EC 5.4.99.-) (gene: rsuA). This enzyme is responsible for the formation of pseudouridine from uracil-516 in 16S ribosomal RNA.
  • Escherichia coli and Haemophilus influenzae ribosomal large subunit pseudouridine synthase B (rluB).
  • Bacillus subtilis ribosomal large subunit pseudouridine synthase B (rluB).
  • Escherichia coli ribosomal large subunit pseudouridine synthase F (rluF).
  • Escherichia coli and Haemophilus influenzae ribosomal large subunit pseudouridine synthase E (rluE).
  • Aquifex aeolicus hypothetical protein AQ_554.
  • Aquifex aeolicus hypothetical protein AQ_1464.
  • Bacillus subtilis hypothetical protein ytzF.
  • Borrelia burgdorferi hypothetical protein BB0129.
  • Helicobacter pylori hypothetical protein HP1459.
  • Synechocystis strain PCC 6803 hypothetical protein slr0361.
  • Synechocystis strain PCC 6803 hypothetical protein slr0612.

These are proteins of from 25 to 40 Kd which contain a number of conserved regions in their central section. They can be picked up in the database by the following highly conserved pattern.

Last update:

April 2005 / Text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

PSI_RSU, PS01149; Rsu family of pseudouridine synthase signature  (PATTERN)


Reference

1AuthorsWrzesinski J., Bakin A., Nurse K., Lane B.G., Ofengand J.
TitlePurification, cloning, and properties of the 16S RNA pseudouridine 516 synthase from Escherichia coli.
SourceBiochemistry 34:8904-8913(1995).
PubMed ID7612632



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