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PROSITE entry PS01209


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PURL: https://purl.expasy.org/prosite/signature/PS01209

Direct ScanProsite submission
General information about the entry

Entry name [info] LDLRA_1
Accession [info] PS01209
Entry type [info] PATTERN
Date [info] 01-NOV-1997 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00929

Name and characterization of the entry

Description [info] LDL-receptor class A (LDLRA) domain signature.
Pattern [info] 
C-[VILMA]-x(5,6)-C-[DNH]-x(3)-[DENQHT]-C-x(3,4)-[STADEW]-[DEH]-[DE]-
x(1,5)-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 828 in 166 different sequences
Number of true positive hits 827 in 165 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 15
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.88 %
Recall (true positives / (true positives + false negatives)) 98.22 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 31
Site [info] disulfide at position 1
Site [info] disulfide at position 4
Site [info] disulfide at position 8
Site [info] disulfide at position 14
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 165 sequences 

AEGP_HUMAN  (Q6UXC1), AEGP_MOUSE  (A2AJA7), AEGP_RAT(Q63191), 

CD320_BOVIN (A6QNY1), CD320_HUMAN (Q9NPF0), CD320_MOUSE (Q9Z1P5), 
CD320_RAT   (Q5HZW5), CDA1_BOMMO  (H9J9M0), CFAI_HUMAN  (P05156), 
CFAI_MOUSE  (Q61129), CFAI_PONAB  (Q5R5A4), CFAI_RAT(Q9WUW3), 
CO6_BOVIN   (Q29RU4), CO6_HUMAN   (P13671), CO6_MOUSE   (E9Q6D8), 
CO6_PANTR   (P61134), CO6_PONPY   (P61135), CO6_RAT (Q811M5), 
CO7_BOVIN   (Q29RQ1), CO7_HUMAN   (P10643), CO7_MOUSE   (D3YXF5), 
CO7_PIG (Q9TUQ3), CO7_PONAB   (Q5RAD0), CO8A_HUMAN  (P07357), 
CO8A_MOUSE  (Q8K182), CO8A_RABIT  (P98136), CO8B_HUMAN  (P07358), 
CO8B_MOUSE  (Q8BH35), CO8B_PAROL  (Q9PVW7), CO8B_RABIT  (P98137), 
CO8B_RAT(P55314), CO9_BOVIN   (Q3MHN2), CO9_HORSE   (P48770), 
CO9_HUMAN   (P02748), CO9_MOUSE   (P06683), CO9_ONCMY   (P06682), 
CO9_RABIT   (P48747), CO9_RAT (Q62930), CO9_TAKRU   (P79755), 
CORIN_HUMAN (Q9Y5Q5), CORIN_MOUSE (Q9Z319), CORIN_RAT   (Q80YN4), 
CPROH_CONVC (A0A0F7YYX3), CTX_ACAES   (B2DCR8), EGG1_CAEBR  (A8X765), 
EGG1_CAEEL  (Q09967), EGG1_CAERE  (E3LYX0), EGG2_CAEEL  (Q21629), 
ENTK_BOVIN  (P98072), ENTK_HUMAN  (P98073), ENTK_MOUSE  (P97435), 
ENTK_PIG(P98074), GLBL_LAMSP  (P16222), GLBL_TYLHE  (P18207), 
GLBM_TYLHE  (P18208), GR101_LYMST (P46023), IDD_HUMAN   (P98153), 
IDD_MOUSE   (P98154), LDLR1_XENLA (Q99087), LDLR2_XENLA (Q99088), 
LDLR_BOVIN  (P01131), LDLR_CRIGR  (P35950), LDLR_HUMAN  (P01130), 
LDLR_MOUSE  (P35951), LDLR_PIG(Q28832), LDLR_RABIT  (P20063), 
LDLR_RAT(P35952), LRAD1_HUMAN (Q5T700), LRAD3_HUMAN (Q86YD5), 
LRAD3_MOUSE (A2AR95), LRAD3_XENTR (A4IHY6), LRAD4_HUMAN (O15165), 
LRAD4_MOUSE (Q8BWJ4), LRP10_HUMAN (Q7Z4F1), LRP10_MOUSE (Q7TQH7), 
LRP11_HUMAN (Q86VZ4), LRP11_MOUSE (Q8CB67), LRP12_HUMAN (Q9Y561), 
LRP12_MACFA (Q9BE74), LRP12_MOUSE (Q8BUJ9), LRP12_PONAB (Q5R662), 
LRP1B_HUMAN (Q9NZR2), LRP1B_MOUSE (Q9JI18), LRP1_CHICK  (P98157), 
LRP1_HUMAN  (Q07954), LRP1_MOUSE  (Q91ZX7), LRP1_RAT(G3V928), 
LRP2_HUMAN  (P98164), LRP2_MOUSE  (A2ARV4), LRP2_PIG(C0HL13), 
LRP2_RAT(P98158), LRP3_HUMAN  (O75074), LRP3_RAT(O88204), 
LRP4_HUMAN  (O75096), LRP4_MOUSE  (Q8VI56), LRP4_RAT(Q9QYP1), 
LRP5_HUMAN  (O75197), LRP5_MOUSE  (Q91VN0), LRP6_HUMAN  (O75581), 
LRP6_MOUSE  (O88572), LRP8_CHICK  (Q98931), LRP8_HUMAN  (Q14114), 
LRP8_MOUSE  (Q924X6), LRP_CAEEL   (Q04833), LTK_DANRE   (F1QVU0), 
MALR1_HUMAN (Q5VYJ5), MALR1_MOUSE (A2AJX4), MFRP_HUMAN  (Q9BY79), 
MFRP_MOUSE  (Q8K480), MLRP1_ACRMI (B3EWZ5), MLRP2_ACRMI (B3EWZ6), 
MODSP_DROME (Q9VER6), NETO1_HUMAN (Q8TDF5), NETO1_MOUSE (Q8R4I7), 
NETO2_HUMAN (Q8NC67), NETO2_MOUSE (Q8BNJ6), NETO2_RAT   (C6K2K4), 
NUDEL_DROME (P98159), PGBM_HUMAN  (P98160), PGBM_MOUSE  (Q05793), 
PROH4_APIME (P85831), PROH4_CAMFO (E2AX35), RXFP1_HUMAN (Q9HBX9), 
RXFP1_MOUSE (Q6R6I7), RXFP1_PONAB (Q5R5V8), RXFP1_RAT   (Q6R6I6), 
RXFP2_CANLF (Q5XM32), RXFP2_HUMAN (Q8WXD0), RXFP2_MOUSE (Q91ZZ5), 
SORL_CHICK  (Q98930), SORL_HUMAN  (Q92673), SORL_MOUSE  (O88307), 
SORL_RABIT  (Q95209), SORL_RAT(P0DSP1), SPIT1_HUMAN (O43278), 
SPIT1_MOUSE (Q9R097), SSPO_BOVIN  (P98167), SSPO_CHICK  (Q2PC93), 
SSPO_HUMAN  (A2VEC9), SSPO_MOUSE  (Q8CG65), SSPO_RAT(Q700K0), 
ST14_BOVIN  (Q0IIH7), ST14_HUMAN  (Q9Y5Y6), ST14_MOUSE  (P56677), 
SVH1_CAEEL  (Q17800), TMPS2_HUMAN (O15393), TMPS2_MOUSE (Q9JIQ8), 
TMPS3_HUMAN (P57727), TMPS3_MOUSE (Q8K1T0), TMPS6_HUMAN (Q8IU80), 
TMPS6_MOUSE (Q9DBI0), TMPS7_HUMAN (Q7RTY8), TMPS7_MOUSE (Q8BIK6), 
TMPS7_RAT   (P86091), TMPS9_HUMAN (Q7Z410), TMPS9_MOUSE (P69525), 
TMPS9_RAT   (P69526), UNC52_CAEEL (Q06561), VGR_SOLIN   (Q6X0I2), 
VLDLR_CHICK (P98165), VLDLR_HUMAN (P98155), VLDLR_MOUSE (P98156), 
VLDLR_RABIT (P35953), VLDLR_RAT   (P98166), YL_DROME(P98163)
» more

UniProtKB/Swiss-Prot
False negative sequences		 15 sequences 

ALK_HUMAN   (Q9UM73), ALK_MOUSE   (P97793), GLU2B_BOVIN (Q28034), 

GLU2B_HUMAN (P14314), GLU2B_MOUSE (O08795), MIG13_CAEEL (G5EF33), 
PKD1_HUMAN  (P98161), PKD1_MOUSE  (O08852), RSVR_COTJA  (P98162), 
SCD2_CAEEL  (O76411), TMPS4_HUMAN (Q9NRS4), TMPS4_MOUSE (Q8VCA5), 
TMPSD_HUMAN (Q9BYE2), TMPSD_MOUSE (Q5U405), YL54_CAEEL  (P34434)
» more

UniProtKB/Swiss-Prot
False positive sequences		 1 sequence 

MYCB2_DANRE (F1RD40)


				
	

	

		PDB
[Detailed view]		
		
			128 PDB
			


			pdb_00001ajj; pdb_00001cr8; pdb_00001d2j; pdb_00001d2l; pdb_00001f5y; pdb_00001f8z; pdb_00001j8e; pdb_00001ldl; pdb_00001ldr; pdb_00001n7d; pdb_00001v9u; pdb_00001xfe; 
			
				pdb_00002fcw; pdb_00002fyj; pdb_00002fyl; pdb_00002i1p; pdb_00002jm4; pdb_00002knx; pdb_00002kny; pdb_00002kri; pdb_00002lgp; pdb_00002m0p; pdb_00002m7p; pdb_00002m96; 
				pdb_00002xrc; pdb_00003a7q; pdb_00003dpr; pdb_00003m0c; pdb_00003ojy; pdb_00003p5c; pdb_00003t5o; pdb_00004a5w; pdb_00004e0s; pdb_00004zrp; pdb_00004zrq; pdb_00005b4x; 
				pdb_00005b4y; pdb_00005fmw; pdb_00005h7v; pdb_00005o32; pdb_00005oy9; pdb_00005oyl; pdb_00006byv; pdb_00006cxo; pdb_00006dlw; pdb_00006h03; pdb_00006h04; pdb_00007f56; 
				pdb_00007f57; pdb_00007f59; pdb_00007f5a; pdb_00007f5b; pdb_00007fff; pdb_00007ffl; pdb_00007ffn; pdb_00007meq; pdb_00007n1h; pdb_00007nyc; pdb_00007nyd; pdb_00007qbd; 
				pdb_00007qbe; pdb_00007qbf; pdb_00007qbg; pdb_00007tmw; pdb_00007wqx; pdb_00007xyd; pdb_00007y0e; pdb_00007y0f; pdb_00008b0f; pdb_00008b0g; pdb_00008b0h; pdb_00008de6; 
				pdb_00008em4; pdb_00008em7; pdb_00008hd8; pdb_00008ihp; pdb_00008jhz; pdb_00008ji0; pdb_00008jut; pdb_00008juu; pdb_00008jx8; pdb_00008jx9; pdb_00008jxa; pdb_00008jxb; 
				pdb_00008jxc; pdb_00008jxd; pdb_00008jxe; pdb_00008jxf; pdb_00008jxg; pdb_00008jxh; pdb_00008jxi; pdb_00008jxj; pdb_00008s0l; pdb_00008s0m; pdb_00008s0n; pdb_00008s9p; 
				pdb_00008ua4; pdb_00008ua8; pdb_00008ufb; pdb_00008ufc; pdb_00008vgt; pdb_00008x0k; pdb_00008x0l; pdb_00008x0m; pdb_00008xi4; pdb_00008xi5; pdb_00008y1d; pdb_00008y1e; 
				pdb_00008y7x; pdb_00008y7y; pdb_00008y87; pdb_00008y88; pdb_00008y89; pdb_00008y8a; pdb_00008y8b; pdb_00008yoy; pdb_00008yqq; pdb_00008ys2; pdb_00008ys4; pdb_00008yvz; 
				pdb_00008yw0; pdb_00008yw1; pdb_00008yw2; pdb_00009bd8; pdb_00009bde; pdb_00009bdt; pdb_00009coo; pdb_00009izn
			
			

			» more