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PROSITE documentation PDOC00955 [for PROSITE entry PS01241] |
The Link domain [1] is a hyaluronan(HA)-binding region found in proteins of vertebrates that are involved in the assembly of extracellular matrix, cell adhesion, and migration. It is about 100 amino acids in length. The structure has been shown [2] to consist of two α helices and two antiparallel β sheets arranged around a large hydrophobic core similar to that of C-type lectin <See PDOC00537>. As shown in the schematic representation this domain contains four conserved cysteines involved in two disulfide bonds.
+----------+ | | ************|*********** xxxxCxxxxxxxxxxxCxxxxxxxxxxCxxxxxxxxxxxxxxxCxxxxx | | +--------------------------------------+
'C': conserved cysteine involved in a disulfide bond. '*': position of the pattern.
The Link domain has also been termed HABM [1] (HA binding module) and PTR [3] (proteoglycan tandem repeat). Proteins with such a domain are listed below:
We developed a signature pattern for this domain, which is located in the middle of the sequence and covers the first three conserved cysteines. We also developed a profile, which covers the entire Link domain.
Last update:December 2004 / Pattern and text revised.
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PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Barta E. Deak F. Kiss I. |
Title | Evolution of the hyaluronan-binding module of link protein. | |
Source | Biochem. J. 292:947-949(1993). | |
PubMed ID | 8318021 |
2 | Authors | Kohda D. Morton C.J. Parkar A.A. Hatanaka H. Inagaki F.M. Campbell I.D. Day A.J. |
Title | Solution structure of the link module: a hyaluronan-binding domain involved in extracellular matrix stability and cell migration. | |
Source | Cell 86:767-775(1996). | |
PubMed ID | 8797823 |
3 | Authors | Brisset N.C. Perkins S.J. |
Source | FEBS Lett. 388:211-216(1996). |
4 | Authors | Peach R.J. Hollenbaugh D. Stamenkovic I. Aruffo A. |
Title | Identification of hyaluronic acid binding sites in the extracellular domain of CD44. | |
Source | J. Cell Biol. 122:257-264(1993). | |
PubMed ID | 8314845 |