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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE entry PS01353


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PURL: https://purl.expasy.org/prosite/signature/PS01353

Direct ScanProsite submission
General information about the entry

Entry name [info] HEMATOPO_REC_L_F2
Accession [info] PS01353
Entry type [info] PATTERN
Date [info] 01-DEC-2001 CREATED;
01-DEC-2001 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC01051

Name and characterization of the entry

Description [info] Long hematopoietin receptor, gp130 family signature.
Pattern [info] 
N-x(4)-S-x(28,35)-[LVIM]-x-W-x(0,3)-P-x(5,9)-[YF]-x(1,2)-[VILM]-
x-W.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 26 in 26 different sequences
Number of true positive hits 22 in 22 different sequences
Number of 'unknown' hits 0
Number of false positive hits 4 in 4 different sequences
Number of false negative sequences 2
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 84.62 %
Recall (true positives / (true positives + false negatives)) 91.67 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 22 sequences 

CSF3R_HUMAN (Q99062), CSF3R_MOUSE (P40223), I12R1_HUMAN (P42701), 

I12R2_BOVIN (Q9BEG2), I12R2_HUMAN (Q99665), I12R2_MOUSE (P97378), 
I12R2_PIG   (Q8MJS1), IL6RB_HUMAN (P40189), IL6RB_MOUSE (Q00560), 
IL6RB_RAT   (P40190), LEPR_HUMAN  (P48357), LEPR_MACMU  (Q9MYL0), 
LEPR_MOUSE  (P48356), LEPR_PIG(O02671), LEPR_RAT(Q62959), 
LIFR_CANLF  (Q5XNR9), LIFR_HUMAN  (P42702), LIFR_MOUSE  (P42703), 
LIFR_RAT(O70535), OSMR_HUMAN  (Q99650), OSMR_MOUSE  (O70458), 
OSMR_RAT(Q65Z14)
» more

UniProtKB/Swiss-Prot
False negative sequences		 2 sequences 

I12R1_MOUSE (Q60837), I27RA_HUMAN (Q6UWB1)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			4 sequences
			


			
FND3B_HUMAN (Q53EP0), FND3B_MOUSE (Q6NWW9), GET1_CRYNB  (P0CS59), 

			
GET1_CRYNJ  (P0CS58)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			36 PDB
			


			pdb_00003l5h; pdb_00003l5i; pdb_00003l5j; pdb_00008av2; pdb_00008avb; pdb_00008avc; pdb_00008avd; pdb_00008ave; pdb_00008avf; pdb_00008avo; pdb_00008b7q; pdb_00008c7m; 
			
				pdb_00008d6a; pdb_00008d74; pdb_00008d7r; pdb_00008d82; pdb_00008d85; pdb_00008dh8; pdb_00008dh9; pdb_00008dha; pdb_00008dpt; pdb_00008odx; pdb_00008odz; pdb_00008oe0; 
				pdb_00008oe4; pdb_00008pb1; pdb_00008qy4; pdb_00008qy5; pdb_00008qy6; pdb_00008v29; pdb_00008v2a; pdb_00008v2b; pdb_00008v2c; pdb_00008x80; pdb_00008x81; pdb_00008x85
			
			

			» more