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PROSITE documentation PDOC01051 [for PROSITE entry PS01353]

Long hematopoietin receptor, gp130 family signature





Description

A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors [1,2] and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two major structural groups: Large/long and small/short hematopoietins.

One subset of individual receptor chains that are part of receptor complexes for large hematopoietins contain common structural elements in their extracellular parts: an immunoglobin-like domain, an hematopoietin-receptor domain, and 3 fibronectin type-III domains (2 in the leptin receptor). This subgroup was designated as "gp130 family of receptors" [3] and contains the following chains:

  • Leptin receptor (LPTR).
  • Granulocyte colony stimulating factor receptor (GCSFR).
  • Interleukin-6/-11/LIF/OSM/CNTF common β chain (GP130).
  • Leukemia inhibiting factor receptor (LIFR).
  • Oncostatin-M receptor β chain (OSMR).
  • Interleukin-12 receptor β-1 chain (IL12RB1).
  • Interleukin-12 receptor β-2 chain (IL12RB2).

A schematic representation of the structure of these receptors is shown below:

 +-------+-------------------------+-----------------xxxxxxx-----------------+
 |Ig-like| C C  C  C Extracellular |    FnIII (x3)   XXXXXXX   Cytoplasmic   |
 +-------+-|-|--|--|---------------+-----------------xxxxxxx-----------------+
           | |  |  |                              Transmembrane
           +-+  +--+

These receptor chains homodimerize (GCSFR, GP130, LPTR) or heterodimerize (GP130 with LIFR or OSMR, IL12RB1 with IL12RB2) upon binding of the cognate cytokine: G-CSF, LIF, OSM, LPT, or the cytokine/α chain complex: IL-6/IL6RA, IL-11/IL11RA, CNTF/CNTFRA, IL-12 (p35/p40) [4,5].

We have used one pattern to detect this family. The motif covers the c-terminal end of the first fibronectin III domain and the n-terminal part of the second fibronectin III domain.

Expert(s) to contact by email:

Boulay J.-L.

Last update:

December 2001 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

HEMATOPO_REC_L_F2, PS01353; Long hematopoietin receptor, gp130 family signature  (PATTERN)


References

1AuthorsBoulay J.-L. Paul W.E.
TitleHematopoietin sub-family classification based on size, gene organization and sequence homology.
SourceCurr. Biol. 3:573-581(1993).
PubMed ID15335670

2AuthorsSprang S.R. Bazan J.F.
SourceCurr. Opin. Struct. Biol. 3:815-827(1993).

3AuthorsMosley B. De Imus C. Friend D. Boiani N. Thoma B. Park L.S. Cosman D.
TitleDual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation.
SourceJ. Biol. Chem. 271:32635-32643(1996).
PubMed ID8999038

4AuthorsKishimoto T. Taga T. Akira S.
TitleCytokine signal transduction.
SourceCell 76:253-262(1994).
PubMed ID8293462

5AuthorsPresky D.H. Yang H. Minetti L.J. Chua A.O. Nabavi N. Wu C.Y. Gately M.K. Gubler U.
TitleA functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.
SourceProc. Natl. Acad. Sci. U.S.A. 93:14002-14007(1996).
PubMed ID8943050



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