|PROSITE documentation PDOC50078 [for PROSITE entry PS50078]|
A subgroup of serine/threonine protein kinases (see <PDOC00100>) playing multiple role during cell cycle, especially in M phase progression and cytokinesis, contain a duplicated domain in their C-terminal part, the POLO box . It is named after its founding member encoded by the polo gene of Drosophila . This domain of around 70 amino acids has been found in species ranging from yeast to mammals.
Point mutations in the POLO box of the budding yeast CDC5 protein abolish the ability of overexpressed CDC5 to interact with the spindle poles and to organize cytokinetic structures .
Some of the proteins that contain a POLO box are listed below:
December 2001 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|Title||Polo-like kinases: positive regulators of cell division from start to finish.|
|Source||Curr. Opin. Cell Biol. 10:776-83(1998).|
|2||Authors||Llamazares S., Moreira A., Tavares A., Girdham C., Spruce B.A., Gonzalez C., Karess R.E., Glover D.M., Sunkel C.E.|
|Title||polo encodes a protein kinase homolog required for mitosis in Drosophila.|
|Source||Genes Dev. 5:2153-2165(1991).|
|3||Authors||Song S., Grenfell T.Z., Garfield S., Erikson R.L., Lee K.S.|
|Title||Essential function of the polo box of Cdc5 in subcellular localization and induction of cytokinetic structures.|
|Source||Mol. Cell. Biol. 20:286-298(2000).|