|PROSITE documentation PDOC50097 [for PROSITE entry PS50097]|
The BTB domain (Broad-Complex, Tramtrack and Bric a brac) is also known as the POZ domain (POxvirus and Zinc finger). It is a homodimerization domain occurring at the N-terminus of proteins containing multiple copies of either zinc fingers of the C2H2 type (see <PDOC00028>) or Kelch repeats [1,2]. Many BTB proteins are transcriptional regulators that are thought to act through the control of chromatin structure.
The structure of the BTB domain of the promyelocytic leukemia zinc finger (PLZF) protein has been determined by X-ray crystallography and reveals a tightly intertwined dimer with an extensive hydrophobic interface . A surface-exposed groove lined with conserved amino acids is formed at the dimer interface, suggesting a peptide-binding site.
Some proteins known to contain a BTB/TTK domain are listed below:
December 2001 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Zollman S. Godt D. Prive G.G. Couderc J.L. Laski F.A.|
|Title||The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila.|
|Source||Proc. Natl. Acad. Sci. U.S.A. 91:10717-10721(1994).|
|2||Authors||Bardwell V.J. Treisman R.|
|Title||The POZ domain: a conserved protein-protein interaction motif.|
|Source||Genes Dev. 8:1664-1677(1994).|
|3||Authors||Ahmad K.F. Engel C.K. Prive G.G.|
|Title||Crystal structure of the BTB domain from PLZF.|
|Source||Proc. Natl. Acad. Sci. U.S.A. 95:12123-12128(1998).|