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PROSITE documentation PDOC50172 [for PROSITE entry PS50172] |
The breast cancer susceptibility gene contains at its C-terminus two copies of a conserved domain that was named BRCT for BRCA1 C-terminus. This domain of about 95 amino acids exists in a large number of proteins from prokaryotes to eukaryotes. BRCT domain-containing proteins are involved in multiple cellular responses, including cell cycle checkpoint control, DNA repair, and transcription regulation [1,2,3]. The BRCT domain is not limited to the C-termini of protein sequences and can be found in multiple copies or in a single copy as in RAP1 and TdT. Aside from a role as phospho-peptide modules, BRCT domains have been implicated in phosphorylation-independent protein interactions, DNA binding and poly(ADP-ribose) (PAR) binding [4,5].
The BRCT domain fold is comprised of a central 4-stranded β-sheet flanked by a single α-helix (α2) on one side and two α-helices (α1 and α3) on the opposite side (see <PDB:1CDZ>) [5,6].
Some proteins known to contain a BRCT domain are listed below:
The profile we developed covers the entire BRCT domain.
Expert(s) to contact by email: Last update:December 2019 / Text revised.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Koonin E.V. Altschul S.F. Bork P. |
Title | BRCA1 protein products ... Functional motifs... | |
Source | Nat. Genet. 13:266-268(1996). | |
PubMed ID | 8673121 | |
DOI | 10.1038/ng0796-266 |
2 | Authors | Bork P. Hofmann K. Bucher P. Neuwald A.F. Altschul S.F. Koonin E.V. |
Title | A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. | |
Source | FASEB J. 11:68-76(1997). | |
PubMed ID | 9034168 |
3 | Authors | Callebaut I. Mornon J.-P. |
Title | From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. | |
Source | FEBS Lett. 400:25-30(1997). | |
PubMed ID | 9000507 |
4 | Authors | Yu X. Chini C.C.S. He M. Mer G. Chen J. |
Title | The BRCT domain is a phospho-protein binding domain. | |
Source | Science 302:639-642(2003). | |
PubMed ID | 14576433 | |
DOI | 10.1126/science.1088753 |
5 | Authors | Leung C.C.Y. Glover J.N.M. |
Title | BRCT domains: easy as one, two, three. | |
Source | Cell. Cycle. 10:2461-2470(2011). | |
PubMed ID | 21734457 | |
DOI | 10.4161/cc.10.15.16312 |
6 | Authors | Zhang X. Morera S. Bates P.A. Whitehead P.C. Coffer A.I. Hainbucher K. Nash R.A. Sternberg M.J. Lindahl T. Freemont P.S. |
Title | Structure of an XRCC1 BRCT domain: a new protein-protein interaction module. | |
Source | EMBO J. 17:6404-6411(1998). | |
PubMed ID | 9799248 | |
DOI | 10.1093/emboj/17.21.6404 |