|PROSITE documentation PDOC50172 [for PROSITE entry PS50172]|
The breast cancer susceptibility gene contains at its C-terminus two copies of a conserved domain that was named BRCT for BRCA1 C-terminus. This domain of about 95 amino acids is found in a large variety of proteins involved in DNA-repair, recombination and cell cycle control [1,2,3]. The BRCT domain is not limited to the C-termini of protein sequences and can be found in multiple copies or in a single copy as in RAP1 and TdT. Recent data  indicate that the BRCT domain functions as a protein-protein interaction module.
The structure of the first of the two C-terminal BRCT domains of the human DNA repair protein XRCC1 has recently been determined by X-ray crystallography .
Some proteins known to contain a BRCT domain are listed below:
December 2001 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Koonin E.V. Altschul S.F. Bork P.|
|Title||BRCA1 protein products ... Functional motifs...|
|Source||Nat. Genet. 13:266-268(1996).|
|2||Authors||Bork P. Hofmann K. Bucher P. Neuwald A.F. Altschul S.F. Koonin E.V.|
|Title||A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins.|
|Source||FASEB J. 11:68-76(1997).|
|3||Authors||Callebaut I. Mornon J.-P.|
|Title||From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair.|
|Source||FEBS Lett. 400:25-30(1997).|
|4||Authors||Zhang X. Morera S. Bates P.A. Whitehead P.C. Coffer A.I. Hainbucher K. Nash R.A. Sternberg M.J. Lindahl T. Freemont P.S.|
|Title||Structure of an XRCC1 BRCT domain: a new protein-protein interaction module.|
|Source||EMBO J. 17:6404-6411(1998).|