|PROSITE documentation PDOC50196 [for PROSITE entry PS50196]|
RanBP proteins form a heterogeneous family of proteins involved in nuclear transport. Among them, some contain a common region (RanBD1) involved in the binding of Ran, a Ras-related GTPase (see <PDOC00859>). This domain binds RanGTP and increases the rate of RanGAP1-induced GTP hydrolysis. RanBD1 displays some similarity with the WASP domain [1,2].
The crystal structure of RanBD1 of the human protein RanBP2 complexed with Ran, bound to a non-hydrolysable GTP analogue, has been resolved (see <PDB:1RRP>) . Like the WASP domain, RanBD1 show a PH domain fold (see <PDOC50003>), although there is no detectable sequence similarity. Ran-GTP contacts RanBD1 in four different points, "embracing" RanBD1. This conformation can stabilize the binding of GTP to Ran.
The following proteins contain a RanBD1 domain:
The profile we developed covers the entire RanBD1 domain.Last update:
May 2002 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Mattaj I.W. Englmeier L.|
|Title||Nucleocytoplasmic transport: the soluble phase.|
|Source||Annu. Rev. Biochem. 67:265-306(1998).|
|2||Authors||Melchior F. Gerace L.|
|Title||Two-way trafficking with Ran.|
|Source||Trends Cell Biol. 8:175-179(1998).|
|3||Authors||Vetter I.R. Nowak C. Nishimoto T. Kuhlmann J. Wittinghofer A.|
|Title||Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport.|