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PROSITE documentation PDOC50196 [for PROSITE entry PS50196] |
RanBP proteins form a heterogeneous family of proteins involved in nuclear transport. Among them, some contain a common region (RanBD1) involved in the binding of Ran, a Ras-related GTPase (see <PDOC00859>). This domain binds RanGTP and increases the rate of RanGAP1-induced GTP hydrolysis. RanBD1 displays some similarity with the WASP domain [1,2].
The crystal structure of RanBD1 of the human protein RanBP2 complexed with Ran, bound to a non-hydrolysable GTP analogue, has been resolved (see <PDB:1RRP>) [3]. Like the WASP domain, RanBD1 show a PH domain fold (see <PDOC50003>), although there is no detectable sequence similarity. Ran-GTP contacts RanBD1 in four different points, "embracing" RanBD1. This conformation can stabilize the binding of GTP to Ran.
The following proteins contain a RanBD1 domain:
The profile we developed covers the entire RanBD1 domain.
Last update:May 2002 / First entry.
PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Mattaj I.W. Englmeier L. |
Title | Nucleocytoplasmic transport: the soluble phase. | |
Source | Annu. Rev. Biochem. 67:265-306(1998). | |
PubMed ID | 9759490 | |
DOI | 10.1146/annurev.biochem.67.1.265 |
2 | Authors | Melchior F. Gerace L. |
Title | Two-way trafficking with Ran. | |
Source | Trends Cell Biol. 8:175-179(1998). | |
PubMed ID | 9695834 |
3 | Authors | Vetter I.R. Nowak C. Nishimoto T. Kuhlmann J. Wittinghofer A. |
Title | Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport. | |
Source | Nature 398:39-46(1999). | |
PubMed ID | 10078529 | |
DOI | 10.1038/17969 |