The PWWP domain is an around 70 amino acids domain that was named after its
central core 'Pro-Trp-Trp-Pro'. The PWWP domain is found in one or, less
frequently, in two copies in nuclear, often DNA-binding proteins that function
as transcription factors regulating developmental processes. Due to its
position, the composition of amino acids close to the PWWP motif and the
pattern of other domains present, it has been proposed that the PWWP domain is
involved in protein-protein interactions .
Conservation of the PWWP domain is concentrated on one major and two minor
blocks with length differences occurring in between .
Some proteins known to contain a PWWP domain are listed below:
Human WHSC1 protein, encoded by a gene located in the Wolf-Hirschorn
syndrome critical region.
Human bromodomain and PHD finger-containing protein 1 (BRPF1/Peregrin) and
3 (BRPF3). These are possible transcription activators.
Human bromodomain-containing protein 1 (BRD1).
Human BS69 protein, highly expressed in colon carcinoma. It interacts with
E1A specifically suppressing E1A-activated transcription.
Mammalian hepatoma-derived growth factor (HDGF), an heparin-binding
protein, with mitogenic activity for fibroblasts.
Mammalian DNA mismatch repair protein MSH6.
Vertebrate DNA-cytosine-methyltransferase type 3 (DNMT3).
The profile we developed covers the entire PWWP domain.
December 2001 / First entry.
PROSITE method (with tools and information) covered by this documentation:
Stec I. Nagl S.B. van Ommen G.-J.B. den Dunnen J.T.
The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?
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