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PROSITE documentation PDOC50812 [for PROSITE entry PS50812] |
The PWWP domain is an around 70 amino acids domain that was named after its central core 'Pro-Trp-Trp-Pro'. The PWWP domain is found in one or, less frequently, in two copies in nuclear, often DNA-binding proteins that function as transcription factors regulating developmental processes. Due to its position, the composition of amino acids close to the PWWP motif and the pattern of other domains present, it has been proposed that the PWWP domain is involved in protein-protein interactions [1].
Conservation of the PWWP domain is concentrated on one major and two minor blocks with length differences occurring in between [1].
Some proteins known to contain a PWWP domain are listed below:
The profile we developed covers the entire PWWP domain.
Last update:December 2001 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Stec I. Nagl S.B. van Ommen G.-J.B. den Dunnen J.T. |
Title | The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation? | |
Source | FEBS Lett. 473:1-5(2000). | |
PubMed ID | 10802047 |