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PROSITE documentation PDOC50836 [for PROSITE entry PS50836]

DOMON domain profile





Description

The DOMON domain is an 110-125 residue long domain which has been identified in the physiologically important enzyme dopamine β-monooxygenase and in several other secreted and transmembrane proteins from both plants and animals. It has been named after DOpamine β-MOnooxygenase N-terminal domain. The DOMON domain can be found in one to four copies and in association with other domains, such as the Cu-ascorbate dependent monooxygenase domain, the epidermal growth factor domain (see <PDOC00021>), the trypsin inhibitor-like domain (TIL), the SEA domain (see <PDOC50024>), and the Reelin domain. The architectures of the DOMON domain proteins strongly suggest a function in extracellular adhesion [1,2].

The sequence conservation is predominantly centered around patches of hydrophobic residues. The secondary structure prediction of the DOMON domain points to an all-β-strand fold with seven or eight core strands supported by a buried core of conserved hydrophobic residues. There is a characteristic motif with two small positions (Gly or Ser) corresponding to a conserved turn immediately C-terminal to strand three. It has been proposed that the DOMON domain might form a β-sandwich structure, with the strands distributed into two β sheets as is seen in many extracellular adhesion domains such as the immunoglobulin, fibronectin type-III, cadherin and PKD (see <PDOC50093>) domains [1].

Some proteins known to contain a DOMON domain are listed below:

  • Mammalian dopamine β-monooxygenase (DM). It is involved in the conversion of dopamine to the catecholamine noradrenaline, a crucial physiological modulator of the sympathetic nervous system, T-cell-mediated immunity and fetal development.
  • Drosophila tyramine-β-hydroxylase (TBH), an orthologue of DM. It is needed for the biosynthesis of the neurotransmitter octopamine from tyramine.
  • Human brain protein C9orf4.
  • Mouse SDR2 protein.
  • Botryllus schlosseri PAR protein, a soluble immunoglobulin molecule homologue.
  • Caenorhabditis elegans uncharacterized protein C09F9.2.
  • Arabidopsis thaliana uncharacterized protein At5g54830.

The profile we developed covers the entire DOMON domain.

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html --------------------------------------------------------------------------------.

Last update:

November 2003 / Profile revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

DOMON, PS50836; DOMON domain profile  (MATRIX)


References

1AuthorsAravind L.
TitleDOMON: an ancient extracellular domain in dopamine beta-monooxygenase and other proteins.
SourceTrends Biochem. Sci. 26:524-526(2001).
PubMed ID11551777

2AuthorsPonting C.P.
TitleDomain homologues of dopamine beta-hydroxylase and ferric reductase: roles for iron metabolism in neurodegenerative disorders?
SourceHum. Mol. Genet. 10:1853-1858(2001).
PubMed ID11532994



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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