![]() |
|
PROSITE documentation PDOC50900 [for PROSITE entry PS50900] |
The PLAC (protease and lacunin) domain is a six cysteine region of about 40 residues which is present at or near the C-termini of:
The PLAC domain is found associated with other domains such as the thrombospondin type I repeat (TSP1) (see <PDOC50092>), the Kunitz proteinase inhibitor domain (see <PDOC00252>), the Ig-like domain (see <PDOC50835>), the WAP domain, the subtilase domain (see <PDOC00125>), or the ADAM type metalloprotease domain (see <PDOC50215>). The function of the PLAC domain is not yet known [1,2].
The profile we developed covers the entire PLAC domain.
Last update:October 2003 / First entry.
-------------------------------------------------------------------------------
PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Nardi J.B. Martos R. Walden K.K.O. Lampe D.J. Robertson H.M. |
Title | Expression of lacunin, a large multidomain extracellular matrix protein, accompanies morphogenesis of epithelial monolayers in Manduca sexta. | |
Source | Insect Biochem. Mol. Biol. 29:883-897(1999). | |
PubMed ID | 10528409 |
2 | Authors | Cal S. Obaya A.J. Llamazares M. Garabaya C. Quesada V. Lopez-Otin C. |
Title | Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. | |
Source | Gene 283:49-62(2002). | |
PubMed ID | 11867212 |