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	PROSITE documentation PDOC50919 [for PROSITE entry PS50919]

MIR domain profile

The protein mannosyltransferase, inositol 1,4,5-trisphosphate receptor (IP3R) and ryanodine receptor (RyR) (MIR) domain is an ~50-residue motif found generally in multiple copies in:

• Eukaryotic protein O-mannosyl-transferases (EC 2.4.1.109).
• Eukaryotic stromal cell-derived factor 2 (SDF-2).
• Animal inositol 1,4,5-trisphosphate receptors.
• Animal ryanodine receptors.
• Chlamydia trachomatis protein CT153.

As single MIR domains are found in the chlamydial proteins and in a splice variant of mouse tape-2 IP3R, it is proposed that MIR domains represent independent structural units, rather than being tandem repeats arranged within a single structural domain. The MIR domain can be found associated with other domains such as MAC/Perforin domain, SPRY, RyR repeated domain, EF-hand domain (see <PDOC00018>) or RIH. The function of the MIR domain is not yet known [1].

The profile we developed covers the entire MIR domain.

Last update:

August 2003 / First entry.

PROSITE method (with tools and information) covered by this documentation:

MIR, PS50919; MIR domain profile  (MATRIX)

• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 62
  • detected by PS50919: 62 (true positives)
  • undetected by PS50919: 0 (false negative or 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS50919:
  NONE.
• Domain architecture view of Swiss-Prot proteins matching PS50919
  
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS50919
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS50919
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS50919
• View ligand binding statistics of PS50919
• Matching PDB structures: 1N4K 1XZZ 2MC2 2XOA ... [ALL]

1	Authors	Ponting C.P.
	Title	Novel repeats in ryanodine and IP3 receptors and protein O-mannosyltransferases.
	Source	Trends Biochem. Sci. 25:48-50(2000).
	PubMed ID	10664581

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