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PROSITE documentation PDOC50919 [for PROSITE entry PS50919] |
The protein mannosyltransferase, inositol 1,4,5-trisphosphate receptor (IP3R) and ryanodine receptor (RyR) (MIR) domain is an ~50-residue motif found generally in multiple copies in:
As single MIR domains are found in the chlamydial proteins and in a splice variant of mouse tape-2 IP3R, it is proposed that MIR domains represent independent structural units, rather than being tandem repeats arranged within a single structural domain. The MIR domain can be found associated with other domains such as MAC/Perforin domain, SPRY, RyR repeated domain, EF-hand domain (see <PDOC00018>) or RIH. The function of the MIR domain is not yet known [1].
The profile we developed covers the entire MIR domain.
Last update:August 2003 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Ponting C.P. |
Title | Novel repeats in ryanodine and IP3 receptors and protein O-mannosyltransferases. | |
Source | Trends Biochem. Sci. 25:48-50(2000). | |
PubMed ID | 10664581 |