|PROSITE documentation PDOC50927 [for PROSITE entry PS50927]|
Although this domain is a mannose-binding lectin in the bulb super-family, curculin is considered as a non-functional mannose-binding protein devoid of mannose-binding activity .
Each bulb-type lectin domain consists of three sequential β-sheet subdomains (I, II, III) that are inter-related by pseudo three-fold symmetry (see <PDB:1MSA>). The three subdomains are flat four-stranded, antiparrallel β-sheets. Together they form a 12-stranded β-barrel in which the barrel axis coincides with the pseudo 3-fold axis .
The profile we developed covers the entire bulb-type lectin domain.Last update:
September 2003 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Barre A. Van Damme E.J.M. Peumans W.J. Rouge P.|
|Title||Curculin, a sweet-tasting and taste-modifying protein, is a non-functional mannose-binding lectin.|
|Source||Plant Mol. Biol. 33:691-698(1997).|
|2||Authors||Hester G. Kaku H. Goldstein I.J. Wright C.S.|
|Title||Structure of mannose-specific snowdrop (Galanthus nivalis) lectin is representative of a new plant lectin family.|
|Source||Nat. Struct. Biol. 2:472-479(1995).|