The SWIRM domain is a globular module of about 85 residues that was named
after the proteins SWI3, RSC8 and MOIRA in which it was first recognized. It
is found in eukaryotic chromatin proteins and several other uncharacterized
proteins. The SWIRM domain occurs in various distinct domain-architecture
contexts, suggesting that it is an evolutionarily mobile domain. It is found
associated with other domains, such as the ZZ-type zinc finger (see
<PDOC50135>), the Myb DNA-binding domain (see <PDOC00037>), the HORMA domain
(see <PDOC50815>), the amino-oxidase domain, the chromo domain (see
<PDOC00517>) and the JAB1/PAD1domain. The SWIRM domain is predicted to mediate
specific protein-protein interactions in the assembly of chromatin-protein
Secondary structure predictions indicate the presence of four distinct α
helices. Hence it is predicted that the SWIRM domain is likely to form a
globular structure in the form of a tetrahelical bundle .
Some proteins known to contain a SWIRM domain are listed below:
Saccharomyces cerevisiae transcription regulatory protein SWI3. It is a
component of the SWI/SNF global transcription activator complex.
Saccharomyces cerevisiae RSC8. It is a component of the RSC complex.
Drosophila MOIRA, a brahma-associated putative chromatin-remodeling factor.
Rice protein similar to putative SWI/SNF complex subunit BAF170.
Arabidopsis thaliana meiotic asynaptic mutant 1 protein, a homolog of the
yeast HOP1 protein.
Eukaryotic transcriptional adapter 2-like (ADA2-like) protein. It is a
chromatin associated protein that is known to mediate protein-protein
Caenorhabditis elegans suppressor of presenilin 5, a potential amine
oxidoreductase, which probably acts as a corepressor protein.
The profile we developed covers the entire SWIRM domain.
October 2003 / First entry.
PROSITE method (with tools and information) covered by this documentation:
Aravind L., Iyer L.M.
Genome Biol. 3:1-7(2002).
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