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PROSITE documentation PDOC51037 [for PROSITE entry PS51037]

YEATS domain profile


The YEATS (for YNL107w, ENL, AF-9, and TFIIF small subunit) domain is a ~120-amino acid module, which is often found in subunits of complexes involved in chromatin modification and transcriptional regulation. The structure and function of the YEATS domain are unknown [1,2].

Some proteins known to contain a YEATS domain are listed below:

  • Yeast YNL107w or YAF9 (yeast AF-9) protein, a nonessential NuA4 histone acetyltransferase (HAT) subunit that also associates with the SWR1 complex, which deposits the histone H2A variant Htz1.
  • Yeast something about silencing protein 5 (SAS5), a subunit of the SAS HAT complex.
  • Yeast transcription initiation factor TFIID subunit 14 (TAF14), a component of the NuA3 (SAS3) HAT complex which is also associated with the SWI/SNF ATPase remodeling complex and the TFIIF and TFIID RNA polymerase II transcription complexes.
  • Human Glioma-amplified sequence-41 (Gas41), a member of the TIP60 complex, which might be the human counterpart of the yeast NuA4 complex.
  • Human AF-9 protein.
  • Human ENL protein.

The profile we developed covers the entire YEATS domain.

Last update:

November 2004 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

YEATS, PS51037; YEATS domain profile  (MATRIX)


1AuthorsLe Masson I. Yu D.Y. Jensen K. Chevalier A. Courbeyrette R. Boulard Y. Smith M.M. Mann C.
SourceMol. Cell. Biol. 23:6086-6102(2003).

2AuthorsZhang H. Richardson D.O. Roberts D.N. Utley R. Erdjument-Bromage H. Tempst P. Cote J. Cairns B.R.
TitleThe Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres.
SourceMol. Cell. Biol. 24:9424-9436(2004).
PubMed ID15485911

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