PROSITE documentation PDOC51043 [for PROSITE entry PS51043]DDHD domain profile
The Nir/rdgB (N-terminal domain-interacting receptor/Drosophila retinal degeneration B proteins) family has been identified in a variety of eukaryotic organisms, ranging from worms to mammals. Members of this family are implicated in regulation of lipid trafficking, metabolism, and signaling. The Nir/rdgB proteins contain a 180 amino-acids-long conserved region in the central part of the protein. This domain contains four conserved residues, DDHD, which may form a metal-binding site. This domain is named DDHD after these four residues. This pattern of conservation of metal-binding residues is often seen in phosphoesterase domains [1].
The DDHD domain is found in the central part of Nir/rdgB proteins, as well as the C-terminal part of the phosphatidic acid-preferring phospholipase A1. The DDHD domain function is not currently known but it may be implicated in phospholipid metabolism, membrane turnover, or intracellular trafficking [1].
The profile we developed covers the entire DDHD domain.
Last update:November 2004 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Lev S. |
| Title | The role of the Nir/rdgB protein family in membrane trafficking and cytoskeleton remodeling. | |
| Source | Exp. Cell Res. 297:1-10(2004). | |
| PubMed ID | 15194420 | |
| DOI | 10.1016/j.yexcr.2004.02.033 |
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